A device is provided that may include an illuminator operable to interrogate at least a lens of an eye. The illuminator may include at least one light source and a lens positioned with respect to the light source to produce interrogating radiation. The device also may include a detector operable to image the total autofluorescence response of the lens of the eye as viewable through a pupil of the eye, the detector comprising an image sensor. The device can also include a controller operable to control operation of the illuminator and the detector. The controller may interrogate at least the lens of the eye by activating the illuminator for a select time, obtain at least one image of the total autofluorescence response of the lens at the detector during or immediately subsequent to the select time, and transmit the at least one image to a remote device.

A cognitive impairment diagnostic device includes: an obtainer that obtains a distribution map representing a distribution of gaze points of a subject on a movie for cognitive assessment; and a diagnoser. The movie for cognitive assessment includes, in time order: a first movie including a first region including an image for encoding displayed in a visually enhanced manner, and a plurality of second regions including normal images displayed without being enhanced; and an assessment movie including a third region including an assessment image similar to the image for encoding and displayed at a same position as the image for encoding without being visually enhanced, and the second regions. The diagnoser calculates, in a distribution map on the assessment movie, a percentage of fixation duration for which the third region is focused on, and makes diagnosis of suspected memory impairment when the percentage of fixation duration is lower than a threshold.

A dynamic neuropsychological assessment tool according to an embodiment utilizes speech recognition, speech synthesis and machine learning to assess whether a patient is at risk for a neurological disorder, such as Alzheimer's disease. The dynamic neuropsychological assessment tool enables self-administration by a patient. The tool performs pre-test validation operations on the test environment, test equipment, and the patient's capability for performing the test at that time. The tool also enables dynamic modification of a questionnaire presented to the patient while the patient completes the questionnaire. Also provides the dynamic modification of which tests to present the patient with. The modification can be rule based or modified by a provider. The dynamic neuropsychological assessment tool enables providers and administrators to modify and improve tests and validate them using machine learning based on previously completed assessments and results.

A method of assessing post SARS infection based neurological injuries using a quantitative, noninvasive, clinical objective, oculomotor, vestibular, reaction time, and cognitive response assessment protocol for evaluating post SARS infection based neurological injuries. The method comprises the steps of: coupling a VOG/VNG system to a subject wherein the VOG/VNG system is configured to present a plurality of Oculomotor, vestibular, reaction time, and cognitive tests to the subject; presenting a plurality of Oculomotor, vestibular, reaction time, and cognitive tests to the subject on the VOG/VNG system; obtaining objective physiologic responses of the patient from the plurality of Oculomotor, vestibular, reaction time, and cognitive tests to the subject via the VOG/VNG system; and using a plurality of the objective physiologic responses of the patient to assess post SARS infection based neurological injuries in the subject.

Provided is a digital mat system for managing and analyzing cognitive and physical abilities of a user that is capable of managing and analyzing individual cognitive and physical abilities of a user (particularly the elderly) and providing a customized solution that matches individual abilities, thereby assisting in preventing geriatric diseases, such as falling and dementia.

A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig's disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

Systems and methods for screening a subject for neuropathology associated with a condition. The method can include providing neurophysiological stimuli to the subject, measuring response by the subject to the neurophysiological stimuli, comparing the measured responses to a reference, determining whether the subject demonstrates abnormal or changed responses to the neurophysiological stimuli according to whether the measured responses differ from the individual's baseline or from the reference by one or more thresholds, and providing an alert according to whether the subject has abnormal or changed responses to the neurophysiological stimuli, wherein the alert comprises an intervention associated with the condition.

The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.

A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig’s disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

A device is provided for stimulating neurons that includes a non-invasive stimulation unit that generates stimuli in multiple stimulation channels. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation channels in different locations. Moreover, the device includes a control unit that controls the stimulation unit to repeatedly generates sequences of the stimuli with the order of the stimulation channels in which stimuli are generated within a sequence being constant for 20 or more successively generated sequences before it is varied.