A method of establishing a brain status indication parameter indicative of a brain disorder is disclosed. The method comprising the steps:—determining a brain energy metabolism indicator of at least a part of the brain of a subject,—determining a skull energy metabolism indicator of at least a part of the skull of said subject,—establishing the brain status indication parameter by at least relating said brain energy metabolism indicator to said skull energy metabolism indicator. Also disclosed are a system for establishing such brain status indication parameter, a computer program, and methods for treating a disease.

A device (10) for assessing a patient's absolute and/or relative risk of cognitive decline and/or dementia, the device (10) comprising: a probe (12) configured to be placed adjacent to a patient's common carotid artery, internal carotid artery or external carotid artery, at least two sensors (101, 102, 104, 106, 108, 110) associated with the probe (12), the sensors being configured to measure one or more of: wave intensity of carotid pulse; wave power of carotid pulse; and pressure waveform of carotid pulse, pulse wave velocity, artery compliance, artery stiffness, artery diameter; micro-emboli count; Heart rate variability; and changes to the eye or retina.

A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

A system and method for collecting symptomatic data to screen for a targeted disease. Testing hardware incorporates a plurality of testing units with corresponding indicators that can be altered to indicate whether a symptom is present or not. The resulting data from the testing use can then be analyzed to determine the likelihood of presence of a disease.

A method for evaluating a treatment for a brain condition, including: extracting one or more microstate parameter values from at least one EEG signal that was measured after the treatment; and evaluating at least one parameter of the treatment based on the one or more microstate parameter values.

A method of detecting decline in activities of daily living (ADLs) over time, the method including gathering a plurality of image data of a subject over a period of time, preprocessing the image data to obtain a plurality of standardized images, segmenting out a feature from each of the image data, providing the segmented features to a trained model to identify possible changes in the features over time, classifying the possible changes as evidence, and using the evidence to calculate a risk score.

The present invention relates to a neural implant comprising a biomaterial having an outer surface with a stochastic nanoroughness (Rq), and the application of said stochastic nanoroughness in the diagnosis and/or treatment of a neurological disorder, such as, for example, Parkinson's disease, Alzheimer's disease, glioblastoma and/or for disrupting, and/or preventing glial scars in the context of mammalian mechanosensing ion channels selected from the family of PIEZO-1 and PIEZO-2 ion channels.

A medical device includes a sensor interface for measuring one or more physiological signals of the patient; at least one motion detector for detecting movement of the device; a processor coupled to the sensor interface and the at least one motion detector; and a memory communicatively coupled to the processor and comprising instructions that cause the processor to receive movement information comprising at least acceleration information and heading information from the at least one motion detector; detect movement of the medical device from the movement information, wherein the movement of the medical device comprises a distance traveled by the medical device and a direction traveled by the medical device; and estimate a current location of the medical device relative to a previous location of the medical device using dead reckoning based at least in part on the distance and direction traveled by the medical device.

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

An external medical device includes monitoring circuitry configured to monitor a cardiac condition of a patient using the external medical device; and a controller configured to: receive at least one of patient input and non-patient user input of a patient's ability; determine a patient interaction mode of the external medical device based on the at least one of the patient input and the non-patient user input; and adapt the patient interaction mode of the external medical device over time based on the at least one of the patient input and the non-patient user input.