A device is provided that may include an illuminator operable to interrogate at least a lens of an eye. The illuminator may include at least one light source and a lens positioned with respect to the light source to produce interrogating radiation. The device also may include a detector operable to image the total autofluorescence response of the lens of the eye as viewable through a pupil of the eye, the detector comprising an image sensor. The device can also include a controller operable to control operation of the illuminator and the detector. The controller may interrogate at least the lens of the eye by activating the illuminator for a select time, obtain at least one image of the total autofluorescence response of the lens at the detector during or immediately subsequent to the select time, and transmit the at least one image to a remote device.

Aspects of the invention include systems for monitoring compliance of a patient with a patch dosage regimen and, where necessary, providing rapid, economical intervention when non-compliance is detected. In some instances, the systems include: a patch comprising an active agent and a patch tag; a reader configured to detect the patch tag; one or more processing devices; and a compliance determination module comprising a computer-readable storage medium comprising instructions that, when executed by the one or more processing devices, determine compliance information from data received from the reader. The compliance information includes data that may be employed to determine whether the patient is complying with the patch dosage regimen. Also provided methods of using the systems, e.g., to monitor patient compliance, as well as components of the systems, e.g., patches, readers, etc.

Provided are compositions and methods for detecting and modulating oscillatory patterns within the basolateral amygdala (BLA) for diagnosis and treatment of anxiety related disorders.

A sightline-position determination device includes: a sightline-position input unit to which a position of a sightline of a user is inputted; a determination region setting unit which sets a determination region; a determination unit which determines whether or not the position of the sightline inputted from the sightline-position input unit falls within the determination region; and an output unit which outputs feedback to the user when the determination unit has determined that the position of the sightline falls within the determination region.

A dementia diagnosis method and system using a brain impedance pattern are disclosed. According to one embodiment, a dementia diagnosis system comprises at least one processor implemented to execute a computer-readable command, and the at least one processor can comprise: an electrode pair control unit for controlling a plurality of electrode pairs so that a current is introduced through each of the plurality of electrode pairs formed by two or more random electrodes from among electrodes attached to a subject to be diagnosed, the two or more random electrodes including electrodes attached in relation to the frontal lobe of the subject to be diagnosed; and a dementia diagnosis unit, which compares the magnitude of the impedance of each of the plurality of electrode pairs as a result of the current being introduced with a preset impedance value to diagnose whether dementia of the subject to be diagnosed has progressed.

A system and method for analyzing the brain activity of a subject during a transition between brain states. Brain activity data including data representative of a transition between brain states is received from a brain monitoring system and processed to obtain a value for one or more transition parameters. The one or more transition parameters are parameters that characterize the transition between brain states and may be used as a biomarker for identifying mental disorders.

Disclosed is a method of identifying, by at least one processor of a device, a cognitive function state of a user. The method may include inputting user information, at least one voice data, and speech time information related to the at least one voice data to a cognitive function state identification model, and identifying a cognitive function state of the user based on first output data that is output by the cognitive function state identification model.

Methods, apparatuses, computer program products, devices and systems are described that carry out accepting user brain activity measurement data; selecting at least one user-health test function at least partly based on the user brain activity measurement data; and applying the at least one user-health test function to at least one interaction between at least one user and at least one device-implemented application.

A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.

A sensor system and process for measuring electromagnetic activity of a brain are provided. The system and process employ a sensor assembly having a plurality of electrodes arranged in a closely spaced arrangement and a processor to determine a weighted average of the signals indicative of an electric field generated by electromagnetic activity of the brain. The system provides a medical body area network of a subject including one or more of the sensor assemblies and one or more additional sensors, which may be within a smartphone or other wearable device.