A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

A method for automatically assessing information processing speed in a test subject is disclosed. In the inventive method, a first qualimetric activity parameter for sensorial transmission, cognition and motoric output activity is determined and a second qualimetric activity parameter for sensorial transmission and motoric output activity is determined. A third qualimetric activity parameter for cognition is determined by comparing the first and the second qualimetric activity parameters to each other, and the information processing speed in the test subject is assessed based on the first, second and third qualimetric activity parameters. The information processing speed can be determined by comparing the determined qualimetric activity parameters to a reference and the subject's cognitive impairment can then be determined from the processing speed. The inventive method can be computer implemented. A mobile device or system for carrying out the disclosed methods is also disclosed.

A biometric sensor device system including a biometric sensor device, and a prediction computer. The biometric sensor device includes at least one camera, and a biometric sensor device processor configured to record a time synchronized communicative interaction between participants, by controlling at least one camera to record the participants over a time period, and transfer the recorded communicative interaction to the prediction computer. The prediction computer including a prediction computer processor configured to extract, from the recorded communicative interaction, a physical characteristic of each of the participants over the time period, compare the physical characteristic of at least one of the participants with the physical characteristic of at least another one of the participants over the time period, and classify or score at least one of the participants according to a predetermined classification or dimensional scoring scheme based on the comparison.

A dementia determination device in a dementia information output system includes an obtainer which obtains, on a per unit period basis, the result of measuring body motion of a user in a sleep time period; and an outputter which outputs dementia information indicating the likelihood that the user is developing a mild cognitive disorder based on the occurrence frequency of a unit period in which the magnitude of a difference between reference data on body motion of a healthy subject in a sleep time period and the result of measuring obtained by the obtainer exceeds a predetermined threshold value.

An estimation system includes: a first sensor that detects a first amount of activity that is an amount of activity of a subject in a room; a second sensor that detects a second amount of activity that is an amount of activity of the subject on a bed in the room; and an estimation device that estimates at least one of a position and an action of the subject in association with a position in the room based on the first amount of activity detected by the first sensor and the second amount of activity detected by the second sensor, and outputs an estimation result obtained from the estimation. The first sensor and the second sensor are sensors other than two-dimensional image sensors.

A method, computer program product, and computing system for monitoring one or more environmental variables concerning a user of a client electronic device configured to administer an alertness test to the user. A disrupter is selected for inclusion within the alertness test based, at least in part, upon the one or more environmental variables concerning the user. The alertness test is administered to the user.

The present disclosure relates to a method and a system for detecting an anomaly within a biological tissue. A first image of the biological tissue is obtained, the first image containing light at a first wavelength. A second image of the biological tissue is obtained, the second image containing light at a second wavelength. A texture analysis of the biological tissue is performed using spatial information of the first and second images. The texture analysis is resolved over the first and second wavelengths.

Systems and methods of the present invention provide for: receiving a digital image data; modifying the digital image data to reduce a width of a feature within the digital image data; executing a dimension reduction process on the feature; storing a feature vector comprising: at least one feature for each of the received digital image data, and a correct or incorrect label associated with each feature vector; selecting the feature vector from a data store; training a classification software engine to classify each feature vector according to the label; classifying the image data as correct or incorrect according to a classification software engine; and generating an output labeling a second digital image data as correct or incorrect.

Disclosed herein is a frailty diagnosis apparatus. The frailty diagnosis apparatus includes a physical performance meter and a processor for determining a frailty index of a target person based on physical performance of the target person obtained by the physical performance meter. The physical performance meter includes at least one among a gait speed meter for measuring a gait speed of the target person, a body balance meter for measuring a body balance maintenance time of the target person, and a muscle strength meter for measuring a muscle exercise time.