A method of diagnosing or assessing risk of a tauopathy in a person is disclosed. The method may comprise collecting a nasal sample of exhaled breath from the person's nose, analyzing the nasal sample to detect the presence of tau protein in the sample, and determining the concentration of tau protein in the nasal sample, wherein the tau protein concentration in the nasal sample indicates susceptibility to the tauopathy.

A cognitive function evaluation device includes: an instruction unit that instructs quick pronunciation of pseudoword in which a predetermined syllable is repeated; an obtainment unit that obtains voice data indicating a voice of an evaluatee who has received an instruction; a calculation unit that calculates a feature from the voice data obtained by the obtainment unit; an evaluation unit that evaluates a cognitive function of the evaluatee from the feature calculated by the calculation unit; and an output unit that outputs a result of the evaluation by the evaluation unit.

There is provided herein systems and methods for managing a subject suffering from cognitive impairment, the method comprising: providing to a subject a cognitive training session; determining at least one aspect of the subject's cognitive performance based on and/or in response to said training session; monitoring one or more life style, physiological and/or medical parameters of the subject before, during and/or after said training session; identifying peaks in the subject's cognitive performance; wherein the identifying comprises comparing the determined cognitive performance to stored cognitive performance data; identifying changes in one or more life style, physiological and/or medical parameters positively or negatively associated with the peak in the cognitive performance; and providing the subject with a life style, physiological and/or medical recommendation based on the on identified association.

Provided is a cognitive impairment diagnosis method including: receiving an electroencephalogram signal of a user by a cognitive impairment diagnosis device; preprocessing the electroencephalogram signal by the cognitive impairment diagnosis device; extracting features, by the cognitive impairment diagnosis device, from the electroencephalogram signal by using a brain connectivity-based analysis method; and outputting cognitive impairment diagnosis information of the user by the cognitive impairment diagnosis device, on the basis of features having a causal relationship with the cognitive impairment diagnosis information, among the extracted features.

A method for indexing cognitive function includes giving, to a subject, a work for inducing biological activity related to cognitive function, acquiring measurement data, and acquiring an index indicating the cognitive function of the subject from the measurement data of the subject using a model constructed in advance.

Systems and methods for quantitative susceptibility mapping (QSM) using magnetic resonance imaging (MRf) and a localized processing technique are described. A field-shift map is processed based on localized regions of local field perturbations. These localized field-shift regions are processed using established QSM algorithms, or using direct dipole inversion techniques, to compute regional susceptibility distributions from the localized field shift information. When the localized regions correspond to subvolumes of the field-shift map, local susceptibility maps can be generated and combined to form a composite quantitative susceptibility map. By computing regional susceptibility distributions based on localized field-shift information, residual streaking artifacts in the susceptibility map are constrained to the individual volumes from which they originate, thereby eliminating their propagation through the image.

The present disclosure relates to a system and a method for determining a perceptual-cognitive signature of a subject. A plurality of objects moves at a controlled speed on a visual display, for a predetermined duration in each of a series of core trials. The subject identifies one or more target objects amongst the plurality of objects. The perceptual-cognitive signature of the subject is determined according to the number of target objects, the speed of the objects, the predetermined duration of each of the series of core trials, and a correctness of identifications, by the subject after each predetermined duration, of the target objects over the series of core trials.

The present disclosure provides systems and methods for assessing a mental state of a subject in a single session or over multiple different sessions, using for example an automated module to present and/or formulate at least one query based in part on one or more target mental states to be assessed. The query may be configured to elicit at least one response from the subject. The query may be transmitted in an audio, visual, and/or textual format to the subject to elicit the response. Data comprising the response from the subject can be received. The data can be processed using one or more individual, joint, or fused models. One or more assessments of the mental state associated with the subject can be generated for the single session, for each of the multiple different sessions, or upon completion of one or more sessions of the multiple different sessions.

A client device is configured to administer unique, equivalent, computer mediated, task versions of a particular task type automatically generated by a task versioning system. Multiple task versions, each comprising of at one stimulus sequence, are generated by performing geometric, symmetric or temporal transformations on the spatiotemporal relationships between one or more stimuli in a task version. Previous user performance may be captured and analyzed to determine a next task version. Task versioning systems with the ability to automatically generate multiple unique, equivalent task versions allow for accurate measurement of neurological, cognitive, and motor skills, by ensuring that learning effects arising from repeated task administrations are eliminated.

Methods, devices and systems for evaluating olfactory function are configured to: electronically estimate a user-specific odorant detection threshold sensitivity threshold using at least one target stimulus odorant delivered to a nose of a user; flowably deliver a plurality of different target stimulus odorants to the nose of the user with defined concentrations of the different target stimulus odorants based, at least in part, on the estimated user-specific odorant detection sensitivity threshold; and evaluate olfactory function of the user based on the user's response to the delivered different target stimulus odorants.