An implant sized and shaped to be endovascularly delivered to the middle meningeal artery includes a carrier that carries a payload between first and second ends thereof. An anchor mechanism associated with the implant transitions into a swollen state in response to exposure to bodily fluids. In the swollen state, said anchor mechanism anchors the implant to the middle meningeal artery. Before or during the transition, the anchor mechanism permits endovascular delivery of the implant to the middle meningeal artery.

A system for monitoring brain activity of a subject, including an implantable measurement device including: a sensor configured to measure electrical activity in the brain; electronic measurement processing devices configured to: receive measurement data from the sensor; use the measurement data to determine if the brain activity of the subject is indicative of an event; and generate event data indicative of the brain activity associated with the event; and an implantable transceiver configured to transmit the event data; an inductive implantable coil configured to inductively receive power; and an external monitoring device including: an external transceiver configured to receive event data from the implantable measurement device; an inductive external coil configured to inductively transmit power to the implantable measurement device; and electronic monitoring processing devices configured to: generate subject data; and transfer the subject data to analysis processing devices for analysis.

A computer-implemented process for continuous monitoring of a brain stroke during a critical rehabilitation period, the process including the steps of: (i) accessing initial image data representing an initial image of a subjects brain containing a stroke region; (ii) accessing scattering parameter data representing microwaves scattered by the subjects brain and originating from a plurality of antennas disposed around the subjects brain; and (iii) processing the scattering parameter data and the initial image data using a gradient-free optimisation method to generate estimates of spatial dimensions of the stroke region within the subjects brain, wherein the initial image of the subjects brain is used as a priori information to improve the accuracy of the generated estimates, and the spatial dimensions of the stroke region are generated as global parameters of the gradient-free optimisation method.

Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

A volatile organic compound collector can include a collector material configured to collect volatile organic compounds given off from a patient's skin; a wrapping configured to isolate the collector material from an external environment; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a mesh layer configured to prevent the collector material from contacting the patient's skin, wherein the collector material is received between the wrapping and the mesh layer.

Embodiments may relate to an air-permeable weight support system, which may include a microclimate fabric layer and an air-permeable capacitive sensor layer below the microclimate fabric layer. The air-permeable capacitive sensor layer may include two air-permeable substrates, each carrying a plurality of electrically conductive pathways that are impermeable to air. The two air-permeable substrates may securely position the electrically conductive pathways to define a sensor grid and position the electrically conductive pathways that are impermeable to air to be spaced apart to define a plurality of air pathways for the air-permeable capacitive sensor layer. The sensor data may be used to determine a sleep state of the person using the weight support system. A computer may identify the poses of the person based on the pressure sensor data. A machine learning model may rely on the poses, the heart rates, the respiration rates to determine the sleep state.

Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

A method comprises determining historical data associated with a subject experiencing epileptic events over a first time period, the historical data comprising non-EEG physiological data recorded over the first time period, and a time at which epileptic events occurred during the first time period. The method further comprises extracting from the non-EEG physiological data, one or more temporal models indicative of a subject specific cycle; and generating one or more temporal probabilistic models based on the respective one or more temporal models, the non-EEG physiological data, and the times at which each epileptic event occurred, wherein each temporal probabilistic model is representative of a probability of future seizure activity in each of a plurality of time windows. The method further comprises providing the one or more temporal probabilistic models for determining an estimate of seizure probability in the subject for one or more of the plurality of time windows.

A system and method for finding a Pareto-optimal solution for automated detection, warning, and abatement of a medical condition based on a cost of event intervention in a patient is disclosed. The method includes acquiring at least one biological signal from the patient via at least one sensor of a medical device, detecting an abnormal biological event based on changes in the biological signal, and delivering at least one of a therapy and a warning. The method includes logging a set of parameters including at least one of a detection parameter, a therapy parameter, and a therapy modality. The method includes identifying an optimal set of parameters that yield a Pareto-optimal cost of event intervention by iteratively determining at least one metric over a time window, determining the cost of event intervention, and modifying at least one parameter, until the cost of event intervention meets an acceptability criteria.

Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.