Isotropic generalized diffusion tensor imaging methods and apparatus are configured to obtain signal attenuations using selected sets of applied magnetic field gradient directions whose averages produce mean apparent diffusion constants (mADCs) over a wide range of b-values, associated with higher order diffusion tensors (HOT). These sets are selected based on analytical descriptions of isotropic HOTs and the associated averaged signal attenuations are combined to produce mADCs, or probability density functions of intravoxel mADC distributions. Estimates of biologically-specific rotation-invariant parameters for quantifying tissue water mobilities or other tissue characteristics can be obtained such as Traces of HOTs associated with diffusion and mean t-kurtosis.

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

A quantification device for the level of lipids and/or proteins present within hepatic tissues. The Device includes: a light source, having at least one vacuum tungsten lamp with a total power of between 0.5 and 2 watts, with a total brightness of between 1000 and 2000 lumens and a total color temperature of between 6000 and 10000 degrees Kelvin; a photosensitive sensor having a sensitivity wavelength of between 800 nm and 2450 nm, configured to capture the light emitted from the light source after diffraction within liver tissues; means for extracting a diffraction spectrum of the light according to an image captured by the photosensitive sensor; and means for analyzing the spectrum in order to determine a level of lipids and/or proteins.

A measurement method includes a first measurement in which a characteristic amount of a specific analyte in a biological fluid is measured with a biosensor. The method also includes a second measurement in which motion information of living activity is measured. Additionally, the method may include recording the motion information and the characteristic amount measured in the first measurement with the motion information and characteristic amount associated with each other.

The present disclosure describes embodiments of a patient monitoring system and methods that include the measure and display of hemoglobin statistics. In an embodiment, total hemoglobin trending is displayed over a period of time. Statistics can include frequency domain analysis, which may be unique for each patient monitored. The total hemoglobin trending and/or statistics can further be used to help control the treatment of a patient, such as being used to control IV administration.

A method to inspect a solid organ in a subject includes introducing a needle in a predetermined area of the solid organ, inserting an optical probe through a lumen of the needle, and imaging the predetermined area using the optical probe. An optical probe to inspect a solid organ in a subject, the optical probe being intended to be positioned in the solid organ through a needle, the optical probe includes an optical fiber bundle, a ferule to protect the distal tip of the optical fiber bundle, the ferule comprising a shank and a head, and a sheath wrapping the fiber bundle and the shank, wherein the head of the ferule has a length adapted for the optical probe to image the solid organ while keeping the sheath inside the needle.

A measurement method includes a first measurement in which a characteristic amount of a specific analyte in a biological fluid with a biosensor having a reagent surface is measured. The method also includes a second measurement in which the tilt angle or rotation angle of the reagent surface from a neutral position, or vibration applied to the reagent surface, as motion information of living activity is measured. Additionally, the method may include recording the motion information, and controlling, based on the motion information, a measurement operation of the first measurement and a recording operation of the recording.

The present invention relates to methods for assessing or obtaining an indication of vascular pressure associated with organs or visceral tissues of the body by using MRI imaging methods. The invention particularly relates to methods for assessing or obtaining an indication of portal hypertension using Magnetic Resonance T1, or T1 and T2* relaxometry, and T1, T2 and/or T2* mapping of the liver or spleen.

The present disclosure describes embodiments of a patient monitoring system and methods that include the measure and display of hemoglobin statistics. In an embodiment, total hemoglobin trending is displayed over a period of time. Statistics can include frequency domain analysis, which may be unique for each patient monitored. The total hemoglobin trending and/or statistics can further be used to help control the treatment of a patient, such as being used to control IV administration.