Apparatuses, systems, and methods are disclosed for noninvasive medical diagnostics using electrical impedance metrics and clinical predictors. An apparatus includes a probe comprising an interrogation electrode that is configured to measure electrical impedance of tissue of a patient's body between the interrogation electrode and a reference electrode. An apparatus includes a processor and a memory that stores code executable by the processor to apply, noninvasively, an electrical current to the tissue of the patient's body using the interrogation electrode of the probe, measure electrical impedance of the tissue of the patient's body between the interrogation electrode of the probe and the reference electrode, and detect a presence of a malignant tumor in the tissue of the patient's body by inputting the measured electrical impedance of the tissue into machine learning. The machine learning is trained on patient data associated with a type of disease that is being diagnosed.

Apparatuses, systems, and methods are disclosed for noninvasively locating and measuring tissue based on real-time feedback. An apparatus includes a probe comprising an interrogation electrode that is configured to measure electrical impedance of tissue of a patient's body between the interrogation electrode and a reference electrode. An apparatus includes a processor and a memory that stores code executable by the processor to apply, noninvasively, an electrical current using the interrogation electrode of the probe to a location on the patient's body to locate and measure an electrical impedance of the tissue of the patient, measure electrical impedance of the tissue between the interrogation electrode of the probe and the reference electrode, and adjust a location of the probe on the patient's body according to feedback based on the measured electrical impedance of the tissue.

A method for detecting cancer involved lymph nodes. The method includes placing a pH-sensing paper inside a needle of an injection syringe, filling the injection syringe with a buffer solution, putting the pH-sensing paper in contact with lymphatic fluid of a lymph node by inserting the needle of the injection syringe inside the lymph node, putting the lymphatic fluid in interaction with the buffer solution by injecting the buffer solution into the lymph node utilizing the injection syringe, and detecting that the lymph node as a cancer involved lymph node if color of the pH-sensing paper is changed to an acidic-range pH color.

A system and method for accounting for motion of a target in a medical procedure includes an endoscope (302) including a tracking mechanism (304) for tracking positions and orientations of the endoscope. Memory storage (310) is configured to record the positions of the endoscope when positioned at or near moving target tissue. A motion sensor (312) is configured to track cyclical motion of an organ such that the cyclical motion of the organ can be correlated to the recorded positions of the endoscope and the target tissue.

An image processing apparatus includes a data acquisition unit configured to acquire, in time series, first image data that have been generated based on acoustic waves generated by irradiating a subject, into which a contrast agent has been injected, with light a plurality of times and that correspond respectively to the plurality of times of light irradiation; and an image generation unit configured to generate second image data indicating a region corresponding to the contrast agent in the plurality of first image data on the basis of the plurality of the first image data acquired in time series.

An aspect provides an image processing apparatus processing three-dimensional image data generated based on a photoacoustic wave generated from inside of a subject. The image processing apparatus includes first three-dimensional image acquisition unit for acquiring first three-dimensional image data in which a first region corresponding to a first substance in the subject is extracted from the three-dimensional image data, second three-dimensional image acquisition unit for acquiring second three-dimensional image data in which a second region corresponding to a second substance in the subject is extracted from the three-dimensional image data, first two-dimensional image acquisition unit for acquiring first two-dimensional image data associated with three-dimensional positional information of the first region from the first three-dimensional image data, and second two-dimensional image acquisition unit for acquiring second two-dimensional image data associated with three-dimensional positional information of the second region from the second three-dimensional image data.

A system and method for imaging tissue including an endoscope capable of illuminating tissue with white and near infrared light. The method includes detecting the fluorescence and displaying the detected fluorescence in combination with white light images

A wearable device includes a housing with a window and an electronic module supported by the housing. The electronic module includes a photoplethysmography sensor, a motion sensor, and a signal processor that processes signals from the motion sensor and signals from the photoplethysmography sensor. The signal processor is configured to remove frequency bands from the photoplethysmography sensor signals that are outside of a range of interest using a band-pass filter to produce pre-conditioned signals, and to further process the pre-conditioned signals using the motion sensor signals to reduce motion artifacts from footsteps during subject running. The device includes non-air light transmissive material in optical communication with the photoplethysmography sensor and the window that serves as a light guide for the photoplethysmography sensor. The window optically exposes the photoplethysmography sensor to a body of a subject wearing the device via the non-air light transmissive material.

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient. The surgical instrument navigation system includes: a surgical instrument; an imaging device which is operable to capture scan data representative of an internal region of interest within a given patient; a tracking subsystem that employs electro-magnetic sensing to capture in real-time position data indicative of the position of the surgical instrument; a data processor which is operable to render a volumetric, perspective image of the internal region of interest from a point of view of the surgical instrument; and a display which is operable to display the volumetric perspective image of the patient.

A monitoring apparatus includes a housing that is configured to be attached to a body of a subject. The housing includes a sensor region that is configured to contact a selected area of the body of the subject when the housing is attached to the body of the subject. The sensor region is contoured to matingly engage the selected body area. The apparatus includes at least one physiological sensor that is associated with the sensor region and that detects and/or measures physiological information from the subject and/or at least one environmental sensor associated with the sensor region that is configured to detect and/or measure environmental information. The sensor region contour stabilizes the physiological and/or environmental sensor(s) relative to the selected body area such that subject motion does not impact detection and/or measurement efforts of the sensor(s).