Monitoring apparatus and methods are provided for assessing a physiological condition of a subject. At least two types of physiological information are detected from a subject via a portable monitoring device associated with the subject, and an assessment of a physiological condition of the subject is made using the at least two types of physiological information, wherein each type of physiological information is individually insufficient to make the physiological condition assessment. Environmental information from a vicinity of a subject also may be detected, and an assessment of a physiological condition of the subject may be made using the environmental information in combination with the physiological information. Exemplary physiological information may include subject heart rate, subject activity level, subject tympanic membrane temperature, and subject breathing rate. Exemplary environmental information may include humidity level information in the vicinity of the subject. An exemplary physiological condition assessment may be subject hydration level.

A wearable audio device includes a housing configured to be positioned at an ear of a subject, a speaker and a chipset within the housing. The chipset includes a plurality of sensor elements, at least one signal processor, at least one digital bus, power regulating circuitry, and at least one wireless transmitter. The sensor elements include at least one optical emitter, at least one optical detector, and at least one noise source. The chipset is positioned within the housing such that the at least one optical emitter and at least one optical detector are in optical communication with the ear via a window in the housing. The at least one signal processor includes sensor signal conditioning algorithms configured to process signals from the sensor elements to generate physiological assessment information about the subject. The at least one wireless transmitter is configured to communicate the physiological assessment information to a remote device.

The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

A coherence gated photoacoustic remote sensing system for imaging a subsurface structure in a sample with optical resolution may include an excitation beam source configured to generate an excitation beam that induces ultrasonic signals in the sample at an excitation location; an interrogation team source configured to generate an interrogation team incident on the sample at an interrogation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals, the interrogation beam being a low-coherent beam; an optical system that focuses the excitation beam onto the sample at an excitation location, and focuses the interrogation beam onto the sample at an interrogation location, at least the interrogation location being below the surface of and within the sample; and a low coherence interferometer that isolates a returning portion of the interrogation beam that corresponds to an interrogation event of the sample.

Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung.

The unobtrusive health-monitoring apparatus includes a camera, a controller, a data transmission port, and, optionally, a graphics processing unit (GPU) which executes nonlinear transformation algorithms. The camera may be inconspicuously disposed within a fixture in the room. The camera collects graphic data which may include still images or video of the user, or both. The GPU may execute the nonlinear transformation algorithms which may transform the graphic data into formats which cannot be recognized by humans. However, these formats preserve features that can be parsed by machine learning methods and used for health tracking purposes. The formats cannot be parsed by humans or be converted back to the original image or video by mathematical inversion or available computational methods. User privacy is thus preserved. The graphic data may be transmitted to a remote processor. The remote processor may perform algorithms which create a health status analyses.

A system for monitoring the cardiopulmonary functioning of a person includes a remote terminal and a sensor module configured to be worn by the person. The sensor module includes at least one physiological sensor configured to sense the following types of physiological information generated by the person: pulse rate, blood flow, and blood pressure; at least one signal processor configured to process signals generated by the at least one physiological sensor; and at least one transmitter responsive to the at least one signal processor that is configured to transmit at least one signal to the at least one remote terminal. The at least one signal processor is configured to focus processing resources on one of the types of physiological information in response to a specified preference by the person.

To solve the problem of differentiating veins from lymphatics in MRI images, among other uses, the disclosed embodiments relate to compositions, kits, systems, and methods that include an MRI contrast agent and an MRI suppression agent that is also a blood pool agent. Using appropriate MRI techniques, the MRI suppression agent will suppress signal in its location, while signal enhanced by the MRI contrast agent in other locations will not be suppressed. The result is a clarified MRI image with only non-vascular regions enhanced.

A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.

Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.