A method for detecting cancer involved lymph nodes. The method includes placing a pH-sensing paper inside a needle of an injection syringe, filling the injection syringe with a buffer solution, putting the pH-sensing paper in contact with lymphatic fluid of a lymph node by inserting the needle of the injection syringe inside the lymph node, putting the lymphatic fluid in interaction with the buffer solution by injecting the buffer solution into the lymph node utilizing the injection syringe, and detecting that the lymph node as a cancer involved lymph node if color of the pH-sensing paper is changed to an acidic-range pH color.

An image capturing and processing device to measure a fluorescence signal in tissue and image a surface of a body part. The device includes a fluorescence image sensor to capture a fluorescence image . The fluorescence image sensor captures time sequence of fluorescence images A peak frequency map unit determines a peak frequency map for an area of interest in the fluorescence images by analyzing the time sequence of fluorescence images. The analyzing includes: determining a time-dependent intensity curve, identifying peaks in the time-dependent intensity curve and determining one or more of a frequency of the identified peaks and a maximum high of the identified peaks, generating a graphic representation of one or more of the determined frequency and maximum high and including the same in the peak frequency map. The peak frequency map together with one or more of the visible light image and the fluorescence image are outputted.

An image capturing and processing device configured to measure a fluorescence signal in a tissue of a limb, to which a fluorescent agent has been added, and of determining a 3D representation of at least a section of the limb. The device including a light source, a fluorescence imaging sensor and processing configured to receive data on a topology of the surface of at least the section of the limb and to determine a 3D representation of at least the section of the limb from the data. The processor is further configured to output the fluorescence image and a visualization of the 3D representation.

Computer based clinical decision support system (CDSS) and method for determining a classification of a lymphedema induced fluorescence pattern. The fluorescence image is determined from a measurement of a fluorescence signal in a tissue of a body part, to which a fluorescent agent 8 has been added. The CDSS including: an input interface through which the fluorescence image, which is specific to a patient, is provided as an input feature to an artificial intelligence (AI) model, one or more processors configured to, perform an inference operation in which the fluorescence image is applied to the AI model to generate the classification of a lymphedema induced fluorescence pattern, and a user interface (UI) through which the classification of the lymphedema induced fluorescence pattern is communicated to a user.

BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient. The surgical instrument navigation system includes: a surgical instrument; an imaging device which is operable to capture scan data representative of an internal region of interest within a given patient; a tracking subsystem that employs electro-magnetic sensing to capture in real-time position data indicative of the position of the surgical instrument; a data processor which is operable to render a volumetric, perspective image of the internal region of interest from a point of view of the surgical instrument; and a display which is operable to display the volumetric perspective image of the patient.

A surgical instrument navigation system is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient. The surgical instrument navigation system includes: a surgical instrument; an imaging device which is operable to capture scan data representative of an internal region of interest within a given patient; a tracking subsystem that employs electro-magnetic sensing to capture in real-time position data indicative of the position of the surgical instrument; a data processor which is operable to render a volumetric, perspective image of the internal region of interest from a point of view of the surgical instrument; and a display which is operable to display the volumetric perspective image of the patient.

A system for collecting a sample from a tissue includes a medical instrument having a sample collection region. One or more sensors is configured to detect one or more properties of a sample, and is configured to output at least one measured value representative of the one or more properties of the sample. An indicator is operatively connected to the one or more sensors and is configured to provide a notification to a user of the medical instrument based on the one or more properties of the sample detected by the at least one sensor. A method of guiding sample collection is also provided.

The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.