Apparatus and methods for hyperspectral imaging analysis that assists in real and near-real time assessment of biological tissue condition, viability, and type, and monitoring the above overtime. Embodiments of the invention are particularly useful in surgery, clinical procedures, tissue assessment, diagnostic procedures, health monitoring, and medical evaluations, especially in the detection and treatment of cancer.

A device for observing a sentinel lymph node (SLN) in a human body. The present invention relates to a device for observing an SLN by detecting near-infrared (NIR) fluorescence caused by a fluorescent material such as indocyanine green (ICG) at the SLN and a method for detecting NIR fluorescence at an SLN. Particularly, in the implementation of a composite image obtained by reproducing a fluorescent material such as ICG and NIR fluorescence emitted by excitation light together with a visible light image, it is possible to detect an SLN with high accuracy through a color contrast method and/or a temporal modulation method using an NIR fluorescence image signal and a visible reflection light image signal.

The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

A light-guiding earpiece configured to be worn by a subject includes a base comprising a speaker and at least one optical detector, a housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a flexible optical emitter configured to be conformable to at least a portion of the earpiece. The housing encloses the speaker and comprises at least one aperture through which sound from the speaker can pass. The flexible optical emitter may be integrally formed within the housing, and the housing may include translucent material that forms a light-guiding region through which light from the flexible optical emitter can pass. The optical detector may be a flexible optical detector.

A cover is configured to be removably attached to and at least partially cover a hearing aid earpiece. The removable cover includes light transmissive material in at least one portion thereof that is configured to guide light from at least one optical emitter associated with the hearing aid earpiece to a region of a body of a subject wearing the hearing aid earpiece and/or guide light from the body of the subject to at least one optical detector associated with the hearing aid earpiece. The removable cover may include at least one alignment member that facilitates stability of the hearing aid earpiece when inserted within an ear of the subject. The removable cover may include at least one lens region, at least one light diffusion region, and/or at least one luminescence region in optical communication with the light transmissive material.

A wearable device includes a pair of earbuds, each earbud configured to be positioned within a respective ear of a subject, a band connecting the pair of earbuds, and a plurality of sensor elements located at respective locations on the band, wherein each of the plurality of sensor elements are configured to obtain physiological information from a respective different region of a body of the subject when the earbuds are positioned within the ears of the subject.

A piece of medical information, e.g., a medical image of tissue, may be received for processing and analysis on a computing device or system. A region of the medical image may be analyzed to determine a presence of one or more contours in the region. One or more properties of the one or more contours may be extracted, where the one or more properties are inputted into a first algorithm to determine an indication of cancer for the region. The indication of cancer may be inputted into a second algorithm to generate a cancer score for the region.

A tubular structure comprising multiple overlapping layers surrounding a lumen has flexibility and structural integrity by allowing portions of the layers to slip relative to each other. One embodiment includes a support layer having a wired coil, braid or weave support element underlies at least one overlying layer. The support layer is fixed to the overlying layer at a bonding point and the remaining portion of the support layer is not fixed to the overlying layer, i.e. free portion. The support layer is permitted to slip at the free portion of the support layer, relative to the overlying layer. Further flexibility may be provided by a coil element of the support layer having substantial gaps between the loops of the coil to impart high flexibility of the tubular structure. In one embodiment, an etched sheath is heat shrunk around an underlying layer with a shrink ratio of 25 percent or less of its original diameter, such that the etchings are at least substantially preserved through the shrinkage process.

Methods and apparatus are presented for removing motion artifacts from physiological signals produced by a physiological sensor of a wearable device, wherein the physiological sensor includes at least one optical emitter and at least one optical detector. Light emitted by the at least one optical emitter that is scattered by a body of a subject wearing the device is detected, and a physiological information signal therefrom is produced via the at least one optical detector. Light emitted by the at least one optical emitter that is scattered by a light regulating region of the wearable device is detected, and a motion noise information signal is produced via the at least one optical detector. The physiological information signal and the motion noise information signal are processed via at least one processor associated with the wearable device to at least partially remove unwanted motion artifacts from the physiological information signal.

The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.