The present invention includes a method of measuring thyroid function comprising identifying a subject in need of measuring thyroid function or structure; providing the subject with an amount of an organified iodine sufficient to cause thyroid follicular cell uptake; and obtaining sufficient spectral computed tomography images of the iodine uptake in thyroid cells over an amount of time sufficient to determine thyroid cellular function.

The present invention provides a system for sensing physiological characteristics. The system includes a stimulating light emitting unit, a potential measuring unit, an analog-to-digital converting unit, a characteristic parameter group filtering unit, a characteristic parameter group storing unit, a comparing and calculating unit, an analysis unit, a display unit and a power supply unit. The present invention utilizes external signal light beams to stimulate the skin to fetch data of potential changes, and further observes the status of various organs or systems in the living creature by numerical means. The characteristic parameter group storing unit with the analysis unit and the display unit can remove the error probability caused by man-made operation in the prior arts, suitable for scientific research applications.

Improved methods and systems for diagnosing and for treating Cushing's syndrome and Cushing's Disease are provided herein, including methods and systems for concurrently treating Cushing's syndrome and differentially diagnosing Cushing's Disease from Ectopic Cushing's Syndrome in a patient with an established diagnosis of ACTH-dependent Cushing's syndrome. Treatment methods can use glucocorticoid receptor antagonists (GRAs), which differentially affect the ratio of cortisol to ACTH levels in patients having Cushing's Disease versus patients having Ectopic Cushing's Syndrome. Methods for concurrently treating and differentially diagnosing Cushing's Disease from Ectopic Cushing's Syndrome include obtaining baseline cortisol and ACTH levels of a patient, treating the patient with a GRA according to a protocol that would typically substantially elevate cortisol levels, obtaining post-treatment cortisol and ACTH levels of the patient, determining a differential relationship between baseline cortisol and ACTH levels and post-treatment cortisol and ACTH levels and providing a positive diagnosis based on the differential relationship.

The present disclosure describes a system and method for estimating hormone levels and physiological conditions of a user by analysing speech samples of said user. A user device of the user may record specifics of speech and use these specifics of speech as a speech sample of user's utterance. The user device may transmit the speech samples to a backend system. The system may isolate phonation segments from the speech samples. The system may filter the one or more phonation segments. The system may isolate uttered speech segments from the one or more phonation segments. The system may perform an acoustic-phonetic analysis of the uttered speech segments. The acoustic-phonetic analysis may use plurality of features for the analysis. The IPA phonemes may be used to derive speech markers that correspond to specific hormones and levels thereof. The system may generate a hormone level report which is transmitted to the user.

Skin-mountable electronic devices and methods suitable for fabricating and using the devices. One embodiment of such a device includes a flexible structure comprising a pattern of individual interconnected traces each comprising a portion of an electrically-conductive layer that overlies and directly contacts an underlying portion of an elastomeric layer. At least some of the portions of the electrically-conductive layer within the pattern are functional electrodes of the skin-mountable electronic device.

An earpiece monitor configured to be worn by a subject includes a battery, an earpiece fitting configured to be inserted within an ear canal of an ear of the subject, a reflective pulse oximeter configured to measure pulse rate and pulse intensity of the subject, a motion sensor configured to monitor footsteps and head motion of the subject, a digital memory for storing at least one algorithm, and a processor configured to process signals from the reflective pulse oximeter and the motion sensor using the at least one algorithm to generate as assessment of a health state of the subject. The earpiece fitting is configured to transmit sound to the inner ear or eardrum of the subject. The assessment of the health state of the subject may include an assessment of subject physiological stress and/or an assessment of overall subject health.

An apparatus adapted to be worn at or near at least one ear of a subject includes a battery, a reflective pulse oximeter, a motion sensor, an analog-to-digital convertor configured to convert analog signals from the reflective pulse oximeter and the motion sensor into digitized information, a speaker, a digital memory device configured to store at least one algorithm for signal processing, a transceiver, and a signal processor. The signal processor is configured to process data from the reflective pulse oximeter to monitor cardiopulmonary functioning of the subject, process data from the motion sensor to monitor head and body motion, execute the at least one algorithm for assessing a health state of a subject, poll the reflective pulse oximeter and the motion sensor at certain time intervals to extend life of the battery, and process digital audio information into analog sounds to be presented to the subject via the speaker.

An apparatus adapted to be worn at or near an ear of a subject includes at least one battery, a plurality of electrodes configured to contact the ear and to sense physiological information from the subject, at least one motion sensor configured to monitor subject body motion, at least one analog-to-digital convertor configured to convert analog sensor signals from the plurality of electrodes into digitized information, at least one speaker configured to supply sound to the subject, at least one digital memory device configured to store at least one algorithm for signal processing, at least one signal processor configured to process data from the plurality of electrodes and the at least one motion sensor using the at least one algorithm to monitor physiological information from the subject, and at least one transceiver configured to enable wireless communication between the apparatus and a remote device.

Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.

Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.