A system that can include a processor that obtains voice data of a subject. The processor can compare the voice data of the subject with reference normal and abnormal voice data. If the voice data of the subject is abnormal, the processor can generate an abnormal subject voice data that is indicative of differences between the subject voice data and the normal voice data. By comparing the generated abnormal subject voice data with the reference normal and abnormal voice data, the processor can determine what condition the subject may be suffering from and the severity of that condition.

An anatomical manometry catheter system, comprising a plurality of balloons on the distal end and being configured to be inflatable and/or deflatable. The system includes a connector assembly coaxially aligned with the catheter assembly, the connector assembly being connectable to the proximal end of the catheter. The connector assembly may have a connector interface connected to the proximal end of the catheter. The connector assembly may include a manifold comprising a plurality of channels configured to deliver the pressure transmission medium therethrough toward a respective catheter lumen for inflating one or more balloons. The connector assembly may include a charging mechanism fluidly coupled to the catheter that facilitates inflating each balloon of the plurality of balloons by a common actuating mechanism so as to simultaneously charge each balloon of the plurality of balloons.

Apparatus for rupturing muscle fibres in a lower oesophageal sphincter comprises a balloon catheter. A multi-electrode impedance planimetry measuring system comprising a pair of stimulating electrodes and sensing electrodes is located on the catheter within the balloon for monitoring the diameter of the balloon when the balloon is inflated with a liquid saline solution from a reservoir through a flowmeter under the control of a microprocessor. The microprocessor computes the minimum diameter value from signals read from the sensing electrodes each time the cumulative volume of the liquid saline solution in the balloon increases by a predefined unit volume. The microprocessor computes a curve of a plot of the minimum diameter values against the corresponding cumulative volume values and determines the slope at each computed minimum diameter value. Rupture of the muscle fibres of the sphincter is determined at the point of inflection of the curve.

According to one aspect, an implantable medical device may include an anchor assembly configured to anchor the medical device to a body lumen. The implantable medical device may also include a capsule. The capsule may include a pH sensor. The pH sensor may be configured to measure a pH of contents within the body lumen. The capsule may also include a power source, a controller, and an impedance sensor. The impedance sensor may be configured to measure an impedance within the body lumen.

A system and a method for automatically and continuously measuring and assessing hemodynamics uses fluorescence imaging in which the fluorescent agent is controlled and automated. A method of automatic perfusion assessment of an anatomical structure of a subject includes administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. A system for automatic perfusion assessment during a medical procedure includes a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of the first fluorescence imaging agent into the blood. The system is configured for receiving and analysing a time series of fluorescence images and determining at least one perfusion parameter based on the analysis.

A method may include positioning a catheter, including at least one electrode, within an esophagus such that the electrode is proximate to at least one sympathetic ganglion. The methods may further include recruiting the sympathetic ganglion via an electrical signal, monitoring the recruitment of the sympathetic ganglion, and, based on the monitoring the recruitment of the sympathetic ganglion, adjusting the electrical signal from the at least one electrode.

A system may include an expandable member, and a plurality of sensors disposed on an outer surface of the expandable member and circumferentially spaced apart from one another, wherein each of the plurality of sensors includes a first emitter configured to emit light of a first wavelength, and a detector configured to detect light, and a controller coupled to the plurality of sensors.

Intraluminal impedance recordings are used to calculate luminal cross-sectional area, or in other words, distension of the esophagus/gastrointestinal tract, during peristalsis using various recording protocols and algorithms derived using the Ohm's law of electricity. Additionally, multiple visual displays of distension-contraction plots of esophageal peristalsis are provided that allows both the relaxation and contraction phase of peristalsis to be easily assessed. These distension-contraction plots can be used to diagnose disorders of the esophagus or other regions of the gastrointestinal tract that result in symptoms such as difficulty swallowing (dysphagia), heartburn, and chest pain, in the case of esophagus. Furthermore, the effects of pharmacological agents/drugs on the distension-contraction measurements can be studied using these protocols and algorithms to treat patients with esophageal symptoms.

A method for evaluating a gastrointestinal tract of a subject may comprise using a sensor located in the subject to obtain data regarding qualities of a tissue of the gastrointestinal tract; using the obtained data, determining a measure of perfusion of blood in the tissue; using the obtained data, determining a measure of thickness of the tissue; using the measure of perfusion and the measure of thickness, determining a measure of inflammation of the tissue; and using one or more of the measure of perfusion, the measure of thickness, and the measure of inflammation, classifying a state of the tissue.

A system and a method for an insertion device positioning guidance system comprising: an electromagnetic field generator configured to generate an electromagnetic field covering a treatment area; a plate sensor configured to be positioned within the treatment area in a location defining an orientation of a subject; a reference sensor configured to be positioned, within the treatment area, on the subject's torso, the reference sensor is configured to define a reference coordinate system representing the position and orientation of the subject's torso relative to said field generator; a registration sensor configured to mark at least a first and a second anatomic locations relative to the reference coordinate system; and a processor configured to operate said field generator, read signals obtained from said the plate sensor, said reference sensor and said registration sensor, calculate a position and orientation thereof relative to said field generator, generate a 3D anatomic map representing the torso of the subject and the first and second anatomic locations, said processor is further configured to facilitate visualization on the 3D anatomic map of a position, orientation and/or path of a tip sensor, located in a distal tip section of the insertion device, with respect to the first and second anatomic locations, independent of the subject's movement and independent of deviations in the position and/or orientation of said field generator, thus determination of a successful medical procedure is facilitated.