A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract. The disclosed method can be effected while monitoring one or more of on-site and off-site parameters such as vital signs, methemoglobin levels, pulmonary function parameters, blood chemistry and hematological parameters, blood coagulation parameters, inflammatory marker levels, liver and kidney function parameters and vascular endothelial activation parameters, such that no substantial deviation from a baseline in seen in one or more of the monitored parameters.

A thermoacoustic imaging system and method for monitoring tissue temperature within a region of interest, which has an object of interest and a reference that are separated by at least one boundary. The system and method include a thermoacoustic imaging system with an adjustable radio frequency (RF) applicator configured to emit RF energy pulses into the tissue region of interest and heat tissue therein, an acoustic receiver configured to receive bipolar acoustic signals generated in response to heating of tissue in the region of interest, and one or more processors that process at least one received bipolar acoustic signal generated in the region of interest in response to the RF energy pulses to determine a peak-to-peak amplitude thereof and calculate a temperature at the at least one boundary using the peak-to-peak amplitude of the at least one bipolar acoustic signal.

Disclosed are piston actuator devices and their uses for magnetic resonance elastography (MRE).

A method and system for estimating fractional fat content of an object of interest. The method and system include a thermoacoustic imaging system comprising an adjustable radio frequency (RF) applicator configured to emit RF energy pulses into the region of interest and heat tissue therein and an acoustic receiver configured to receive bipolar acoustic signals generated in response to heating of tissue in the region of interest; and one or more processors. The one or more processors are able to process bipolar acoustic signals received by the acoustic receiver in response to RF energy pulses emitted into the region of interest using the RF applicator to determine a setting for the RF applicator that yields bipolar acoustic signals with at least one enhanced metric thereof, determine an impedance of the RF applicator used to yield acoustic bipolar signals with the enhanced at least one metric, and estimate fractional fat content of the object of interest using the determined impedance.

The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence-guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

An aspect of the disclosure provides a method of evaluating the nutriture of a subject, comprising (1) calculating the ratio of the .sup.13CO.sub.2 amount to the unlabeled CO.sub.2 amount or total CO.sub.2 amount in an expired air sample obtained from the subject to which a .sup.13C-labeled amino acid was administered; and (2) comparing the ratio with a reference value to evaluate the nutriture. Another aspect of the disclosure provides a composition comprising a .sup.13C-labeled amino acid for evaluating the nutriture of a subject.

A method for assisting navigation of an endoscopic device using a controller with the aid of a digital image data record of an imaging examination modality is provided. The digital image data record describes an image of an object to be examined with the aid of the endoscopic device in a cavity element. A digital two-dimensional or multi-dimensional model of the object to be examined is determined based on the image data record. An operating action that predetermines a relative location of a sensor of the endoscopic device in relation to the object based on the model is received. The model is registered with the endoscopic device and/or a digital endoscopic data record supplied by the endoscopic device. An initial location of the sensor is compared with the predetermined location, and a navigation signal for navigating the endoscopic device is generated taking into account the predetermined relative location.

A noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating a sclera may include at least one light source, at least one detector, and a processor. The at least one light source may direct incident light to illuminate a region of the sclera of an eye of the subject. The at least one detector may receive light, in response to the incident light, from the sclera or from inside the eye proximal to the illuminated region of the sclera. The processor may be configured to compute a ratio of an intensity of the received light from the at least one detector to a reference value and to estimate a level of a substance in the subject from the computed ratio.

A system that assesses health condition by measuring pulse includes: a pulse measuring device that measures an artery of a user who receives assessment of health condition; a terminal that has a function that transmits measured-value data on pulse measured by the pulse measuring device to a health assessing administrator and receives information from the health assessing administrator; an administrative server that is administered by the health assessing administrator, analyzes the measured-value data transmitted from the terminal, and stores various data on health condition that is necessary to assess and analyze health condition. The user transmits the measured-value data on measured pulse from the terminal to the health assessing administrator, and the health assessing administrator transmits assessment information on health condition analyzed by the administrative server to the terminal.

The present invention relates to methods for assessing or obtaining an indication of vascular pressure associated with organs or visceral tissues of the body by using MRI imaging methods. The invention particularly relates to methods for assessing or obtaining an indication of portal hypertension using Magnetic Resonance T1, or T1 and T2* relaxometry, and T1, T2 and/or T2* mapping of the liver or spleen.