A non-transitory storage medium stores instructions readable and executable by at least one electronic processor to perform an imaging method). The method includes: obtaining multi-parametric magnetic resonance (MR) imaging data parameterized by a diffusion weighting or perfusion weighting parameter and a magnetization relaxation parameter for a region of interest (ROI) of a patient; determining volume fraction maps of the ROI for each of a plurality of tissue types from the multi-parametric MR imaging data; and controlling a display device to display a tissue composition map comprising or generated from the determined volume fraction maps.

Methods and apparatus for computer-aided prostate condition diagnosis are disclosed. An example computer-aided prostate condition diagnosis apparatus includes memory to store instructions and a processor. The example processor can detect a lesion from an image of a prostate gland and generate a mapping of the lesion from the image to a sector map, the generating the mapping of the lesion comprising identifying a depth region of the lesion, wherein the depth region indicates a location of the lesion along a depth axis. The processor can also provide the sector map comprising a representation of the lesion within the prostate gland mapped from the image to the sector map.

A urine collector includes a receptacle formed of a water soluble material, which may be a bioplastic, and has a receiving volume for collecting urine therein defined by its shape. The urine collector is flushable and is configured to float in toilet water for use by a user to collect urine. A threshold volume indicator positioned at a level corresponding to a predetermined threshold volume extends around the circumference. The upper interior surface changes color upon contact with urine, a color change of the upper interior surface indicating that the urine collected is greater than the predetermined threshold volume. A patch may be included in the interior surface to detect the presence and/or level of component in the urine indicative of a condition or infection, e.g., ketone, glucose or hormone levels. The urine collector may include a substrate that facilitates separation from a stack of urine collectors.

A user-independent, quantitative, multiparametric MRI model is developed and validated on co-registered correlative histopathology, yielding improved performance for cancer detection over single parameter estimators. A computing device may be configured to receive a first parametric map that maps imaged tissue of a patient using values of a first parameter, and a second parametric map that maps the imaged tissue using values of a second parameter, wherein the parametric maps are generated from medical imaging data for the imaged tissue. The computing device may be further configured to apply a multiparametric model to the maps to generate at least one Composite Biomarker Score for the tissue, the model being a function of the first parameter and the second parameter. The function may be determined based on co-registered histopathology data. The computing device may be further configured to generate an indication of whether the tissue includes predicted cancer, and output the indication.

A system may include a probe configured to transmit ultrasound signals to a target of interest, and receive echo information associated with the transmitted ultrasound signals. The system may also include at least one processing device configured to process the received echo information using a machine learning algorithm to generate probability information associated with the target of interest. The at least one processing device may further classify the probability information and output image information corresponding to the target of interest based on the classified probability information.

A multichannel endorectal coil for prostate MRI, a system, and a working method. The coil comprises a support body provided with a winding curved surface, a plurality of first endorectal coils (1, 2, 3) wrapped around the surface of the support body, and a second endorectal coil stacked on the plurality of first endorectal coils (1, 2, 3); wherein two adjacent first endorectal coils (1, 2, 3) are decoupled by means of partial overlapping, and two non-adjacent first endorectal coils (1, 2, 3) are decoupled by providing a shared capacitor (5); the second endorectal coil comprises a first coil section and a second coil section which are in intersecting connection with one another, the first coil section and the second coil section are arranged symmetrically, and no electrical connection exists at the intersection thereof. The invention increases the number of channels, and further achieves better high-resolution imaging capabilities.

A system for controlling a transrectal probe, for example a transrectal ultrasound probe for echography, comprises a probe and a structure for supporting the probe that is carried by the wrist of a multi-axis manipulator robot. Operatively set between the wrist of the robot and the probe is a load cell. The system further comprises an electronic control unit for controlling the robot and a manual-guide device for guiding the robot, which is connected to the electronic control unit of the robot and comprise a manual-guide member, which can be manoeuvred by an operator for imparting on the robot movements that are function of the movements imparted on the manual-guide member. The electronic control unit of the robot receives signals emitted by the load cell and activates an alarm condition when the load cell signals that a threshold value of the stress detected thereby is exceeded. Preferably, the manual-guide member is pre-arranged for supplying to the operator a haptic feedback, for example of a vibrational type.

The present invention is directed to a toilet that includes a slanted fill tube with an optical proximity sensor positioned on or within the inner surface of the fill tube. The optical proximity sensor includes an incoherent light source and a photodiode. The optical proximity sensor as disclosed herein detects small changes in volumes added to a toilet bowl. Consequently, small volumes of excrement that are deposited in the toilet bowl by a user may be detected with greater accuracy. In some embodiments, information about the volume of urine or feces deposited into the toilet bowl is recorded and calculated by a processor. Other sensors, including a toilet bowl water level sensor and a gas sensor may collect data in combination with the optical proximity sensor to provide more complete information about the user's health.

The present invention is directed to a toilet that includes a liquid level sensor on the surface of a flush jet fill tube. The liquid level sensor is a noncontact electrical impedance sensor that is an electrical capacitor. The capacitor may be used alone or with other volume sensors to detect volume of materials added to a toilet bowl. Some embodiments include a processor which records data and provides reports that may be clinically useful to assess the user's health status. The temporal nature of the liquid level sensor measurements is particularly useful because urination or defecation may be measured over time. Not only are total volumes detected but rates at which waste is deposited into the toilet during the entire excretion event are detected. These measurements are particularly useful in assessing certain health conditions.

Disclosed are compounds and methods useful in the detection of e.g., Zn.sup.2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., Zn.sub.2+. Importantly, the compounds do not exhibit substantial fluorescence in the absence of zinc.