An aspiration device (110) for measuring the viscoelastic deformability of biological tissues and synthetic materials comprises a probe head (11), a probe channel (41), a pressure unit (20), a pressure sensor (31) and a control unit (60). The first probe channel (41) is connecting the pressure unit (20) providing a vacuum with the probe head and includes the pressure sensor (31) detecting the pressure in the first probe channel (41). The first probe channel (41) has a distal end (141) leading with its lower open end (144) through the top wall (14) into the cavity (15) of the probe head. The cavity (15) comprises either an opening (16) in the side or top wall (13, 14) or a second probe channel connected with a valve. A measurement cycle comprises applying under pressure in the first probe channel (41), measuring the under pressure with the pressure sensor (31), detecting a change of under pressure increase over time (301, 401), increasing the under pressure to a predetermined maximum under pressure (303), decreasing the under pressure beyond this point in time and detecting a change of under pressure decrease over time (302, 402).

An apparatus for estimating bio-information is provided. The apparatus for estimating bio-information may include a pulse wave sensor configured to measure a pulse wave signal from an object; a force sensor configured to measure a first force exerted between the object and the pulse wave sensor; and a processor configured to: convert the first force into a second force, based on structure information of the object; and estimate the bio-information, based on the pulse wave signal and the second force.

Systems and methods for determining a patient treatment plan to prevent or treat wrinkles using a neural network. The method includes receiving, by a computing device, patient data including at least a dynamic index and a static index for at least one muscle group of a patient. The method also includes determining, by the computing device, based on the patient data, a patient treatment plan including at least one dose of a treating compound to be administered to the patient at one or more application locations on the patient. The method further includes providing, by the computing device, the patient treatment plan for use in preventing or treating wrinkles on the patient.

Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

Provided are a photography aid tool and a skin photographing device used for photographing skin. A main body is used for photographing skin with a portable device having a photographing device and an illumination device, and is composed of a front plate, a rear plate and a plurality of side plates. The main body has an insertion opening, a partition plate with two openings, and a portable device holder for holding the portable device. A polarizing filter is provided at the opening of the partition plate. The portable device is held by the portable device holder, and the skin photographing window of the front plate is in contact with the skin. The skin surface is photographed using only the light from the illumination device of the portable device while light outside the main body is blocked.

System and method for determining physiological parameters of a person are disclosed. A physiological parameter may be obtained by analyzing a facial image of a person, and determining, from the facial image, a physiological parameter of the person by processing the facial image with a data processor. A neural network model such as regression deep learning convolutional neural network is used to predict the physiological parameter. An image processor screens out images which can't be recognized as facial images and adjust facial images to frontal facial images for predicting of physiological parameters.

Parametric model based computer implemented methods for determining the stiffness of a bone, systems for estimating the stiffness of a bone in vivo, and methods for determining the stiffness of a bone. The computer implemented methods include determining a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f) and fitting a parametric mathematical model to Y(f) and to H(f). The systems include a device for measuring the stiffness of the bone in vivo and a data analyzer to determine a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f). The methods for determining the stiffness include fitting a parametric model to stiffness of the skin-bone complex as a function of frequency H(f) and the compliance of the skin-bone complex as a function of frequency Y(f).

A skin care composition and a method for treating skin, the method including the step of individually displaying a plurality of visual skin guides to a consumer. Each of the visual skin guides includes a plurality of visual representations of a categorical skin condition. Each of the visual representations correspond to a severity score for the categorical skin condition on the visual skin guide. The method further includes providing a skin care system that includes a base oil composition and one or more booster compositions selected based on the severity score for each of the categorical skin conditions for each of the visual skin guides that represent the customer's current skin condition. The booster compositions and oil base formulations are individually packaged and the booster compositions are readily dispersible in the oil base formulation.

In some aspects, the present disclosure provides methods for identifying a disease in an epithelial tissue of a subject. Methods for identifying a disease in an epithelial tissue comprise the generation of a depth profile of the epithelial tissue using signals generated from the tissue by pulses of light directed towards a surface of the epithelial tissue. In some aspects, the present disclosure provides apparatuses consistent with the methods herein.

A skin measurement apparatus for emitting a plurality of lights for photographing an image of the skin. A skin measurement apparatus includes an ultraviolet ray emitting device; a white light emitting device; a focus lens enabling incident light, which is an ultraviolet ray emitted by means of the ultraviolet ray emitting device and a white light emitted by means of the white light emitting device reflected off the skin and transmitted, to pass therethrough; and an emission control device for controlling the ultraviolet ray emitting device and the white light emitting device such that the ultraviolet ray and the white light can be emitted together. The emission control device adjusts the strength of the white light on the basis of white light control information from the outside.