Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

The present specification relates to (S)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid (AZD4017), or a pharmaceutically acceptable salt thereof, for oral use in the treatment or prophylaxis of wounds, for example in diabetic patients. Methods of treatment and prophylaxis and the use of the compound in the preparation of a medicament for the treatment and prophylaxis of wounds are also provided. ##STR00001##

A wound-size measuring method for use in a portable electronic device is provided. The method includes the following steps: obtaining an input image via a camera device of the portable electronic device; using a CNN (convolutional neural network) model to recognize the input image, and selecting a part of the input image with the highest probability of containing a wound as an output wound image; and calculating an actual height and an actual width of the output wound image according to a lens-focal-length parameter reported by an operating system running on the portable electronic device, a plurality of reference calibration parameters corresponding to a pitch angle of the portable electronic device, and a pixel-height ratio and a pixel-width ratio of the output wound image.

An exemplary system is configured to obtain anatomical characteristic data representative of a characteristic associated with an anatomical surface to be covered by a physical medical element, the anatomical surface within an internal space of a patient and determine, based on the anatomical characteristic data, a placement guidance parameter set. The placement guidance parameter set may include one or more parameters configured to guide a placement of the physical medical element on the anatomical surface with one or more surgical instruments controlled by a computer-assisted surgical system.

A system for detecting potential for infection includes a wound dressing and an electronics component. The wound dressing includes a temperature sensing layer and a cover layer comprising a substrate and a backing layer. The electronics component includes a power source, an electronic control unit (ECU), and a communications interface positioned within a housing and removably coupled to the temperature sensing layer of the wound dressing. The electronics component is configured to receive a plurality of temperature readings from the temperature sensing layer, and provide an indication of potential infection of the wound based the plurality of temperature readings. In various embodiments, each of the plurality of temperature readings corresponds to a temperature of an area around a wound. Methods for preventing infections using the system are also described.

The apparatus and method for hemostasis that informs the provider as to whether the appropriate magnitude of pressure is being applied to a puncture site on a patient. A visual pulse indicator can visually convey whether or not there is proper blood flow at the puncture site based on the pulsing motion encountered by the visual pulse indicator on the puncture site. The visual pulse indicator can potentially factor in a variety of different input parameters in displaying information that is useful to providers.

There is provided an apparatus (100) for detecting tissue inflammation. The apparatus (100) comprises a processor (102) configured to acquire, from at least one sensor (104), a plurality of photoplethysmography, PPG, signals indicative of light detected in a region of tissue at a plurality of respective locations within the region. The processor is also configured to process the acquired plurality of PPG signals to determine an amplitude and a phase of each of the plurality of PPG signals and detect tissue inflammation based on the determined amplitude and phase of each of the plurality of PPG signals.

Accordingly, systems and methods have been developed to monitor, diagnose, and predict the course of a wound to aid in determining whether a wound is properly healing. This includes systems and methods that may be performed by the patient in the home in some cases, and some that utilized sensors available on mobile devices. Thus, patients may be able to manage wounds at home without the intervention of caregivers and reduce the costs of admission to hospitals.

Various methods and systems for designing a restored smile are provided. One method includes receiving scan data of a patient's teeth, developing a digital model of the patient's teeth via a computing device, where the model represents the patient's teeth based upon the scan data, creating a dental treatment plan to restore one or more teeth from an initial condition to a successive condition, and wherein a final condition of the one or more is based on the one or more teeth having at least one planned additional restorative tooth structure provided therewith.

A wound therapy system includes a dressing sealable over a wound and defining a wound space between the dressing and the wound, tubing fluidly communicable with the wound space, and a canister fluidly communicable with the tubing. The canister, the tubing, and the dressing define a sealed space that includes the wound space. The wound therapy system also includes a therapy unit coupled to the canister. The therapy unit includes a sensor configured to measure a pressure in the sealed space, a valve positioned between the sealed space and a surrounding environment and controllable between an open position and a closed position, and a control circuit. The control circuit is configured to control the valve to alternate between the open position and the closed position to allow airflow through the valve, receive measurements from the sensor, and determine a volume of the wound space based on the measurements.