A method of delivering a substance to a target location of a subject using an insertion apparatus having a base structure with at least one lumen extending along a length thereof, a cladding layer circumferentially surrounding the base structure and an optically-transmissive coating circumferentially surrounding an exterior of the base layer or an exterior of the cladding layer. The method includes inserting the insertion apparatus into the subject to access the target location, transmitting to tissue adjacent the insertion apparatus, a first optical radiation using the optically-transmissive coating or the cladding layer, receiving, from the tissue, at a processor, data characterizing a second optical radiation via the other of the optically-transmissive coating or the cladding layer based on the first optical radiation and determining whether a tip of the base structure is at the target location, and, if so, releasing a substance into or near the target location.

System for determining heart failure indicator indicative of a heart failure disease state in a subject, including processing device(s) that at least in part control signal generator(s) and receives an indication of a measured response signal from sensor(s) allowing first and second impedance measurement(s) to be performed across at least one body segment, determines a first fluid level indicator using first impedance value(s) obtained by performing the first impedance measurement(s), the first fluid indicator being indicative of a first ratio of ECF to TBW at a first time, determines a second fluid level indicator using second impedance value(s) obtained by performing the second impedance measurement(s), the second fluid indicator being indicative of a second ratio of ECF to TBW at a second time, determines a fluid level change using a difference in the first and second fluid level indicators, and, determines the heart failure indicator using the fluid level change.

A method for measuring the water concentration in a light-diffusing material, includes the following steps: an emission by N light sources of beams with wavelengths; an acquisition by M sensors, sensitive in at least one portion of the wavelengths; wherein M+N>3. The method also includes the steps of: calculating a first piece of information representing the diffusion, and a second piece of information representing the absorption, as a function of the signals and a piece of digital information representing the diffusing material as well as the sources and the sensors; calculating the water concentration in the sample as a function of the second piece of information.

Provided is a test object visualizing device, including: light irradiating unit configured to make wavelength of at least any one of pump light and Stokes light generated on the same optical path variable per test position of test object, and irradiate test object with pump light and Stokes light; molecule distribution image generating unit configured to detect anti-Stokes light emitted from test object according to wavelength difference between pump light and Stokes light, and generate a molecule distribution image based on anti-Stokes light; tomographic image generating unit configured to detect at least any one of reflected light from test object when irradiated with pump light and reflected light from test object when irradiated with Stokes light, and generate a tomographic image of test object based on the reflected light detected; and image display unit configured to display at least any one of molecule distribution image and tomographic image generated.

A system comprises of a pulse oximeter and diffusing wave spectroscopy (DWS) apparatus to perform pulse oximetry measurements. To calculate oxygen saturation, the pulse oximeter utilizes a pulse wave which is measured by an apparatus other than the pulse oximeter itself. In one embodiment, the different apparatus mentioned above is the diffusing wave spectroscopy (DWS) apparatus.

A method and an apparatus for detecting a change of the fluid status or determining the fluid status of an individual are disclosed. The method comprises the following steps: determining a change of the body parameter (RBV) of the individual during a first treatment session (201); determining a first fluid status of the individual (202); calibrating the determined change of the body parameter (RBV) based on the first fluid status (205); determining the change of the body parameter (RBV) of the individual during at least one further treatment session (207); and deriving a fluid status or a change of fluid status individual from the change of the body parameter (RBV) (208).

Techniques and apparatuses for determining fluid volumes of a patient are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to receive baseline bioimpedance information for at least a portion of a human body at a baseline pressure, receive pressurized bioimpedance information of the portion of the human body at a pressurized pressure, the pressurized pressure greater than the baseline pressure and configured to substantially remove blood volume from the portion at the pressurized pressure, and determine at least one of interstitial fluid volume (V.sub.IT) or peripheral blood volume (BV.sub.P) based on the baseline bioimpedance information and the pressurized bioimpedance information. Other embodiments are described.

A system for performing at least one impedance measurement on a biological subject, the system including a measuring device having a signal generator that generates a drive signal, a sensor that measures a response signal and a measuring device processor that at least in part controls the at least one signal generator and receives an indication of a measured response signal from the at least one sensor, allowing the at least one impedance measurement to be performed. The system also includes a connectivity module having a connectivity module housing and electrodes that are provided in electrical contact with the subject in use. Respective first and second connectors are used to electrically connect the sensor and signal generator to the electrodes allowing a drive signal to be applied to the subject via first electrodes and allowing the response signal to be measured via second electrodes so that the at least one impedance measurement can be performed.

A system for performing at least one impedance measurement on a biological subject, the system including a measuring device having a first housing including spaced pairs of foot drive and sense electrodes provided in electrical contact with feet of the subject in use, a second housing including spaced pairs of hand drive and sense electrodes provided in electrical contact with hands of the subject in use, at least one signal generator electrically connected to at least one of the drive electrodes to apply a drive signal to the subject, at least one sensor electrically connected to at least one of the sense electrodes to measure a response signal in the subject and a measuring device processor that at least in part controls the at least one signal generator, receives an indication of a measured response signal from the at least one sensor and generates measurement data indicative of at least one measured impedance value and a client device in communication with the measuring device, the client device being adapted to receive measurement data allowing the client device to display an indicator associated a result of the impedance measurement.

The present disclosure provides apparatuses and methods for measuring sub-epidermal moisture as an indication of tissue viability and providing information regarding the location of a boundary of non-viable tissue.