A living-physics measurement and control system integrates a sensor array, analog front-end, controller module, and feedback actuator network to enable real-time quantification and modulation of energetic organization in open systems. The sensor array comprises thermal, mechanical/vibration, electrical/ionic, and optical sensors, providing multimodal data to the firmware and signal-processing unit. The controller module executes a coherence and entropy feedback control method, which includes system calibration, acquisition of synchronized sensor data, computation of order metrics such as coherence, entropy production, and information flux, and evaluation of energetic organization state. The feedback actuator network, including thermal actuators, mechanical actuators, ionic pumps, and optical emitters, receives actuator command set to dynamically adjust energy flow. The system generates quantitative metrics linking coherence, entropy, and information flow, enabling adaptive feedback to preserve or optimize functional order. The invention addresses the lack of integrated instrumentation and feedback for self-organizing, regenerative stability in open systems.