The present specification discloses systems and methods of patient monitoring in which multiple sensors are used to detect physiological parameters and the data from those sensors are correlated to determine if an alarm should, or should not, be issued, thereby resulting in more precise alarms and fewer false alarms. Electrocardiogram readings can be combined with invasive blood pressure, non-invasive blood pressure, and/or pulse oximetry measurements to provide a more accurate picture of pulse activity and patient respiration. In addition, the monitoring system can also use an accelerometer or heart valve auscultation to further improve accuracy.

Certain aspects of the disclosure are directed to an apparatus including a scale and external circuitry. The scale includes a platform, and data-procurement circuitry for collecting signals indicative of the user's identity and cardio-physiological measurements. The scale includes processing circuitry to process data obtained by the data-procurement circuitry, therefrom generate cardio-related physiologic data, and to send user data to the external circuitry. The external circuitry identifies a risk that the user has a condition based on the reference information and the user data provided by the scale and outputs generic information correlating to the condition to the scale that is tailored based on the identified risk.

Embodiments of the present invention provide a computer-implemented method of determining a parameter indicative of dark adaptation of an eye, comprising receiving threshold data from a dark adaptometer indicative of a perception threshold of the eye, fitting first and second models to the threshold data, wherein the first model is associated with a first dark adaptation mechanism and the second model is associated with the first dark adaption mechanism and a second dark adaptation mechanism, determining a confidence associated with the fitting of each of the first and second models to the received threshold data, iteratively repeating the steps of receiving the threshold data and fitting the first and second models in dependence on the determined confidence, and outputting an indication of one or more parameters indicative of dark adaptation of an eye associated with one or both of the first and second models.

An oximetry device sealed in a sheath directs a user to allow the oximetry device to make oximetry readings at a number of different tissue locations of a patient and average two or more of the oximetry readings by directing the lifts and placements of the oximetry device and sheath to and from the different tissue locations and detecting the lift and placements. The averages are generated and displayed on a display of the device for the oximetry readings if the lifts are made while use directions for the lifts are displayed on a display of the oximetry device. The averages are not generated if the lifts are not made while the user directions for the lifts are not displayed. The averages are simultaneously displayed with the oximetry readings which are instantaneous measurement for patient tissue.

A measurement unit for measuring a bio-impedance of a body, the measurement unit comprising a current generator circuit, a readout circuit, and a baseline cancellation current circuit, wherein the current generator circuit is configured to amplify a reference current to form a measurement current to be driven through a body to generate a measurement voltage representing the bio-impedance; wherein the readout circuit comprises a Instrumentation amplifier (IA) which has a transconductance stage and a transimpedance stage, wherein the IA is configured to: produce a first current in the transconductance stage, the first current being proportional to the measurement voltage, receive a second current from the baseline cancellation current circuit, produce an output voltage in the transimpedance stage, the output voltage being proportional to a difference between the first current and the second current and representative of the measured bio-impedance; wherein the baseline cancellation current circuit is configured to amplify the reference current by a factor to form the second current and deliver it to the IA, wherein the factor is such that that the absolute value of the difference between the first and the second current is below a threshold such that a baseline of the first current is cancelled by the second current.

A method and system is provided for determining a discrimination index in a subject that may be suffering from or at risk for a stress-induced psychiatric disorder. The discrimination index may be equal to a ratio of a subject's cued fear response and non-cued fear response measured during a fear-potentiated startle (FPS) paradigm. Such a value may allow a physician or researcher to quantify how well a subject discriminates between signaled (cued) fear and un-signaled (non-cued) fear, which may be a biomarker for psychiatric disorders like post-traumatic stress disorder, panic disorder, phobias, and/or generalized anxiety disorder. The determined discrimination index may provide a standardized way of diagnosing and evaluating mental illnesses, more uniform treatment of patients, and/or more precise monitoring and evaluation of treatment efficacy.

A system for evaluating a cardiac pumping function includes an oximeter which is attached to a patient for the purpose of recording a pulse oximeter waveform. A computer is connected to the oximeter to receive metric information from the waveform. With this information, the computer determines the value and location of a second derivative acceleration, d.sup.2A/dt.sup.2 in the waveform, which indicates the rate of rise/fall of the waveform. A comparator in the computer then compares this with the value and location of maximum second derivative acceleration, d.sup.2A/dt.sup.2, in earlier waveforms. With this comparison, the computer identifies a trend which can be clinically used to evaluate the efficacy of a cardiac pumping function.

A personal impact monitoring system is described herein comprising a monitoring station that receives impact events sent from personal impact monitors using a monitoring station receiver. The impact events which specify impact parameters associated with the impact events are stored in a data storage location associated with the monitoring station. Software operating on the operating station is configured to receive the impact events from the data storage location and to perform calculations based on the impact events to identify notable impact events.

A computer-implemented method for direct photoplethysmography or direct PPG comprises obtaining during a time interval plural PPG signals for respective sensors in a wearable device; and combining the plural PPG signals to thereby obtain a multi-sensor PPG signal.

Devices and methods for generating synthetic cardio-respiratory signals from one or more ballistocardiogram (BCG) sensors. A method for determining item specific parameters includes obtaining ballistocardiogram (BCG) data from one or more sensors, where the one or more sensors capture BCG data for one or more subjects in relation to a substrate. For each subject, the captured BCG data is pre-processed to obtain cardio-respiratory BCG data. The cardio-respiratory BCG data is sub-sampled to generate the cardio-respiratory BCG data at a cardio-respiratory sampling rate conducive to cardio-respiratory signal generation. The sub-sampled cardio-respiratory BCG data is cardio-respiratory processed to generate a cardio-respiratory parameter set. A synthetic cardio-respiratory signal is generated from at least the cardio-respiratory parameter set and a cardio-respiratory event morphology template. A condition of the subject is determined based on the synthetic cardio-respiratory signal.