A local wearable brain wave cap device for detection is provided to simultaneously detect brainwave and heart rate variability data of a subject and includes a brain wave detection cap, at least one ear electrode and a transmission unit. The brain wave detection cap includes a wearable device and a plurality of electrode units. The wearable device is suitable for arranging the plurality of electrode units on brain wave positions corresponding to head of a subject. Each of the plurality of electrode units includes an accelerator, a storage unit, an input/output unit and a primary amplifier for detecting a brain wave.

A readout integrated circuit (IC) architecture for a tunnelling magnetoresistive (TMR) sensor which uses common mode feedback to achieve a performance level suitable for accurate detection of biomagnetic signals. The architecture uses a three-operational amplifier configuration with chopper stabilization. The architecture may form part of a fully integrated biomagnetic sensor electronics package that includes an array of TMR sensors together with modules for signal amplification and conditioning, data conversion and communication.

A method for evaluating a posture of a rider riding a bicycle includes: continuously receiving a plurality of sensor datasets, each of the sensor datasets being associated with a specific time instance and includes data generated by an inertial measurement set and an electrical signal sensor set; determining a plurality of top time instances and a plurality of bottom time instances, and establishing a number of riding periods based on the plurality of top time instances and the plurality of bottom time instances; and for each of the riding periods, generating an evaluation result with respect to a number of sensor datasets received within the riding period.

An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

The present invention relates to a method and system for estimating blood pressure of a subject. In particular, but not exclusively, the method involves receiving a photoplethysmogram (PPG) signal from a light-based Pulse-Plethysmography sensor applied to the skin of a subject and reconstructing a pulse blood pressure waveform between systolic and diastolic blood pressure of the subject. Additionally, but not exclusively, the method involves processing the pulse blood pressure waveform and reconstructing an absolute blood pressure waveform of the subject.

A device including an array of electrodes generates one or more electrical signals from a user, extracts one or more noise signals, and generates one or more de-noised electrical signals upon processing the electrical signal(s) with the noise signal(s). The array of electrodes is coupled to a surface of the device, where the device also includes force sensors in mechanical communication with the surface for detecting user weight and other forces. The device can be configured to generate electrical signals from different subportions of the array of electrodes and to extract noise signals from different subportions of the array of electrodes, where the subportion(s) for electrical signal generation may or may not overlap with the subportion(s) of electrodes for noise signal extraction.

Systems, methods, and computer program product embodiments are disclosed for removing any fixed frequency interfering signal from an input signal without introducing artifacts that are not part of the original signal of interest. An embodiment operates by using a virtual buffer with a length that matches a length of one cycle of an interfering signal. The embodiment extracts the interfering signal into the virtual buffer. For a sample in the next cycle of the interfering signal that corresponds to a virtual memory location for the virtual buffer, the embodiment can update one or more physical memory locations of the virtual buffer that are in the vicinity of the virtual memory location. This use of virtual buffer can remove any interfering signal without creating the artifacts associated with conventional notch filters.

Methods for evaluating micrometastases in a tissue region of a subject are described. The methods include administering to the subject a detectably effective amount of a tumor-targeted photoactivatable immunoconjugate; allowing a sufficient amount of time for the tumor-targeted photoactivatable immunoconjugate to enter micrometastases in the tissue region; illuminating the tumor-targeted photoactivatable immunoconjugate; obtaining an image of the tissue region of the subject using a fluorescent imaging device, and evaluating the micrometastases in the tissue region by conducting algorithmic analysis of the image. Methods of treating micrometastases in a tissue region of a subject are also described.

A method for continuous acoustic signature recognition and classification includes a step of obtaining an audio input signal from a resonant microphone array positioned proximate to a target, the audio input signal having a plurality of channels. The target produces characterizing audio signals depending on a state or condition of the target. A plurality of features is extracted from the audio input signal with a signal processor. The plurality of features is classified to determine the state of the target. An acoustic monitoring system implementing the method is also provided.

The embodiments of the present disclosure are for a signal processing circuit. The signal processing circuit includes an analog circuit. The analog circuit is used for processing an initial signal it receives. The initial signal includes a target signal and a noise signal. The analog circuit includes a first processing circuit and a second processing circuit. The first processing circuit is used to increase a ratio of the target signal to the noise signal, and output a first processed signal. The second processing circuit is used to amplify the first processed signal. A gain multiple of the second processing circuit to the first processed signal varies with a frequency of the first processed signal. The first processing circuit includes a common mode signal suppression circuit used to suppress a common mode signal in the initial signal, a lowpass filter circuit, and a high-pass filter circuit.