A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.

The present invention relates to a device and a method for detecting a peak of an intracranial pressure (ICP) waveform using a morphological feature of an arterial blood pressure waveform. A peak extracting method of an ICP waveform using a morphological feature of an arterial blood pressure waveform according to an aspect of the present invention includes: extracting a pulse onset from a continuous ICP waveform based on systolic peak from arterial blood pressure waveform; dividing individual ICP waveforms in the continuous ICP waveform based on the pulse onset; deriving a derivative value from each of the ICP waveforms to extract a peak, a trough, and a flat; calculating latencies from the pulse onset extracted in each of the ICP waveforms to the extracted peaks to cluster peaks with a similar time interval and generate a peak cluster; searching a notch from each of the ICP waveforms based on the latency of a dicrotic notch of the arterial blood pressure waveform; and extracting P1, P2, and P3 peaks from each of the ICP waveforms by referring to the searched notch of the ICP.

The present invention relates to a device, system and method for determining an emotional state of a user based on emotion-induced cortisol estimation. The device comprises an interface (11) for obtaining a psychophysiological signal trace (22) indicative of one or more measured stimulus responses corresponding to a neural stress response; a processing unit (12) for processing the psychophysiological signal trace, wherein the processing unit is configured to determine one or more stimulus responses (29) in the psychophysiological signal trace (22); to determine a first contribution (91) to an estimated future cortisol level trace (93) based on the one or more determined stimulus responses (29) in the psychophysiological signal trace (22);to determine a second contribution (92) to the estimated future cortisol level trace (93) based on one or more anticipated future stimulus responses (96); and to determine an estimated future emotional state of the user based on said first and said second contribution to the estimated future cortisol level trace (93). The invention further relates to a corresponding computer program and a wearable device (30).

An example of a system for monitoring and treating respiratory distress in a patient may include signal inputs, a signal processing circuit, and a respiratory distress analyzer. The signal inputs may be configured to receive patient condition signals indicative of autonomic balance of the patient. The signal processing circuit may be configured to process the patient condition signals and to generate patient condition parameters indicative of the autonomic balance using the processed patient condition signals. The respiratory distress analyzer may be configured to determine a state of the respiratory distress using the patient condition parameters, and may include a parameter analysis circuit configured to analyze the autonomic balance of the patient and to determine the state of the respiratory distress using an outcome of the analysis.

A tissue hydration monitor and method includes a sensor module having a plurality of LEDs positioned to emit a plurality of different wavelengths of light toward the user's skin and a detector that detects light transmitted and reflected through the user's skin to generate signals corresponding to an intensity of detected light at each of the different wavelengths. A processor/controller module generates a baseline hydration level based on the received signals, calculates a relative hydration level, and generates an output indicative of relative hydration personalized to the user. The housing is secured against the user's skin by an adhesive patch or a strap.

This disclosure relates generally to a method and a system for determining quality of PPG signal. The PPG signals are extensively used for deducing health parameters of patients to infer the physiological conditions of heart, blood pressure, breathing patterns of the patients. However, analysis based on PPG signals is extremely challenging and is accurate only on high quality PPG signals. However, the existing techniques for determining quality of PPG signal (that are collected using wearable devices) require huge training or use complicated algorithms and cannot be used for real-time analysis. The disclosed methods and system for PPG quality assessment is based on the frequency domain analysis, wherein heart and respiratory components in the frequency spectrum are used effectively to derive the quality checker metric which is further used to estimate a plurality of optimal thresholds that is used for determining the quality of PPG signals at real-time.

In some embodiments, an electric field generator includes a differential oscillator that oscillates at a nominal frequency. The electric field generator is connected to a differential antenna that radiates an electric field. A differential detector measures a frequency of the generated electric field as the electric field interacts with a body (such as a human body) in a reactive near-field region of the electric field. For each of one or more internal components of the body, a computation unit determines a respective periodic behavior in the measured frequency indicative of movement of the internal component. The computation unit also computes, for each of the one or more internal components of the body, a respective rate of movement (such as a heart rate or a respiration rate) of the internal component according to the respective periodic behavior in the measured frequency.

In some embodiments, an electric field generator generates an electric field at a nominal frequency and a nominal amplitude. The electric field generator is connected to an antenna that radiates the electric field. A detector measures a frequency and an amplitude of the generated electric field as the electric field interacts with a body (such as a human body) in a reactive near-field region of the electric field. For each of one or more internal components of the body, a computation unit determines a respective periodic behavior in the measured frequency corresponding to movement of the internal component. The computation unit also computes, for each of the one or more internal components, a respective rate of the movement of the internal component based on the determined respective periodic behavior in the measured frequency. A gain control circuit adjusts the nominal amplitude according to the measured amplitude.

The present invention relates to a device, system and method for determining a vital sign of a person. To improve accuracy and reliability of vital sign determination, the device comprises an input unit (20) for obtaining a vital sign related signal of at least a body part of the person, from which a vital sign can be derived, a body part position determining unit (21) for determining if said body part of the person is in contact with a support or not and generating a contact signal indicating if said body part is in contact with the support or not, a quality metric setting unit (22) for setting, based on said contact signal, a quality metric for use in the determination of a vital sign of the person, and a vital sign deriving unit (23) for deriving a vital sign from the obtained vital sign related signal, wherein the set quality metric is used in the derivation of the vital sign and/or in a judgment of the reliability of a derived vital.

Sleep performance systems and methods of using the same are disclosed. The sleep performance systems can improve the quality of sleep by making one or more recommendations to the subject for increasing a sleep quality score. The sleep performance systems can have one or more electroencephalography (EEG) electrodes configured to measure a subject's brain activity during sleep. The sleep performance systems can have a processor configured to quantify the quality of the subject's slow-wave sleep by determining one or more sleep performance scores associated with the measured brain activity. The sleep performance systems can recommend and/or activate sleep improvement programs based on various threshold scores.