Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The images are generated using acquired .sup.19F magnetic resonance image (MRI) signal data associated with the perfluorinated gas and oxygen mixture.

One aspect of the present subject matter provides an imaging method including: receiving a trigger signal; after a period substantially equal to a trigger delay minus an inversion delay, applying a non-selective inversion radiofrequency pulse to a region of interest followed by a slice-selective reinversion radiofrequency pulse to a slice of the region of interest of a subject; and after lapse of the trigger delay commenced at the cardiac cycle signal, acquiring a plurality of time-resolved images of the slice of the region of interest from an imaging device.

A system can include one or more electrodes; a sensor structure configured to position electrodes over a surface of a body that includes an artery. A capacitance sensing circuit can be coupled to the electrodes and configured to acquire capacitance values of the electrodes over a predetermined time period. The capacitance values can correspond to a distance between the body surface and the at least one electrode. Processor circuits can be configured to generate APW data from the capacitance values. Corresponding methods and devices are also disclosed.

Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and/or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and/or degraded within the GI tract.

A method of imaging a tissue region may comprise visualizing lesions over a tissue region via an imaging catheter by viewing the tissue region through a viewing region purged by a fluid and identifying, with a computer, a location of each of the lesions relative to one another over the tissue region. The method may also include registering, with the computer, a unique set of ablation parameters received from a treatment device for lesion generation for each of the lesions and generating, with the computer, a map of the lesions based on the identified locations of the lesions. The method may also include visually displaying the map of the lesions in a common display with a real-time field of view image of a first lesion; and visually displaying the registered unique set of ablation parameters for the first lesion with the real-time field of view image of the first lesion.

Techniques are disclosed for detecting arrhythmia episodes for a patient. A medical device may receive one or more sensor values indicative of motion of a patient. The medical device may determine, based at least in part on the one or more sensor values, an activity level of the patient. The medical device may determine a heart rate threshold for triggering detection of an arrhythmia episode based at least in part on the activity level of the patient. The medical device may determine whether to trigger detection of the arrhythmia episode for the patient based at least in part on comparing a heart rate of the patient with the heart rate threshold. The medical device may, in response to triggering detection of the arrhythmia episode, collect information associated with the arrhythmia episode.

An assembly 10 and a method for predicting the occurrence of heart disease within an individual 12 by the combined use of echocardiogram data and bodily metric data, such as that which may be obtained from a wearable device 18.

Systems, methods and devices for providing combined ultrasound, electrocardiography, and auscultation data are provided. One such system includes an ultrasound sensor, an electrocardiogram (EKG) sensor, an auscultation sensor, and a computing device. The computing device includes memory and a processor, and the processor receives signals from the ultrasound sensor, the EKG sensor, and the auscultation sensor. Artificial intelligence techniques may be employed for automatically analyzing the data obtained from the ultrasound sensor, the EKG sensor, and the auscultation sensor and producing a clinically-relevant determination based on a combined analysis of the data.

A surgical instrument navigation system and method of use is provided that visually simulates a virtual volumetric scene of a body cavity of a patient from a point of view of a surgical instrument residing in the cavity of the patient, wherein the surgical instrument, as provided, may be a steerable surgical catheter with a biopsy device and/or a surgical catheter with a side-exiting medical instrument, among others. Additionally, systems, methods and devices are provided for forming a respiratory-gated point cloud of a patient's respiratory system and for placing a localization element in an organ of a patient.

Methods, devices, systems, and non-transitory processor-readable storage media are disclosed for determining one or more biometric properties of a subject using multiple sensors positioned along a flexible backing. At least one processor of the multi-sensor device may be configured to receive output signals from the multiple sensors, identify at least one output signal from the received output signals that exhibit measurements of a targeted biological structure, determine the one or more biometric properties of the subject based on the identified at least one output signal received from at least one of the multiple sensors, and provide the determined one or more biometric properties.