Provided herein are cranial implant devices that include at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials. The cranial implant devices are structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject and typically includes a substantially anatomically-compatible shape. In addition, the cranial implant devices permit transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the cranial opening of the subject. Other aspects are directed to various related systems and methods of obtaining diagnostic information from, and/or administering therapy to, a subject.

Disclosed herein are acoustic transmission systems comprising an acoustic wave generator configured to generate an acoustic wave and propagate the acoustic wave through a tissue of a specimen, and a non-Hermitian complementary metamaterial (NHCMM) configured to add a first amount of energy amplification coherently to the acoustic wave to account for energy loss in the acoustic wave as a result of the wave propagating through the tissue of the specimen. The acoustic wave generator can be an ultrasound generator, and the tissue can be a cranium.

The present disclosure describes a therapeutic ultrasound system configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultra sound pulse. In some examples, the system may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

An imaging system of microbubble therapy cooperated with an ultrasound device for monitoring a cavitation on microbubbles in a vessel of an affected part is disclosed in the present invention, in which the cavitation is occurred by applying an ultrasound to disrupt the microbubbles. The system comprises an image acquiring module and a controlling module. The image acquiring module comprises at least one magnetic resonance device for acquiring a plurality of magnetic resonance images of the cavitation, and the controlling module provided for controlling an acquiring time of the magnetic resonance device and an irradiation time of the ultrasonic device through a controlling mode. An image evaluation method using the same is also disclosed herein and comprises steps as the following. First, injecting the microbubbles into the vessel of the affected part is performed. And then, a plurality of magnetic resonance images by a magnetic resonance device and in an acquiring time is acquired. The microbubbles are irradiated for an irradiation time by an ultrasound. Finally, changes of the magnetic resonance images will be monitored, in which an irradiation path of the ultrasound may be perpendicular to a direction of flow in the vessel and the irradiation time is within the acquiring time.

A processing system and a confocal processing method for confocally emitting and receiving ultrasound. Firstly, a first driving electrical signal is generated. Then, at least one first ultrasound signal having a main frequency is emitted to a reflection position according to the first driving electrical signal. With an object at the reflection position, the first ultrasound signal is reflected to form at least one second ultrasound signal. Then, a first analyzed signal whose frequency lower than the main frequency is retrieved from the second ultrasound signal, and other signals are eliminated from the second ultrasound signal, and the first analyzed signal is converted into at least one first analogous signal. Finally, first energy of a first fixed bandwidth of the first analyzed signal is retrieved by the first analogous signal. The method stops generating the first driving electrical signal when the first energy is larger than a predetermined value.

A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multi-channel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multi-modal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.

According to some aspects, there is provided a device configured to determine a measure of brain tissue motion in a brain, comprising: at least one transducer configured to transmit an acoustic signal to at least one region of the brain and receive a subsequent acoustic signal from the at least one region of the brain; and at least one processor configured to: determine the measure of brain tissue motion in the at least one region of the brain by processing the subsequent acoustic signal, wherein processing the subsequent acoustic signal comprises filtering the subsequent acoustic signal. Filtering the subsequent acoustic signal may comprise one of spatiotemporal filtering, signal decomposition, tissue tracking, and/or spectral clustering.

Arrangements described herein relate to systems, apparatuses, and methods for managing gel on a subject to provide gel on a first area of the subject, including controlling a transducer to move to a second area of the subject and controlling the transducer to move the gel to the first area from the second area.

A therapeutic ultrasound method configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion is described. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultrasound pulse. In some examples, the method may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

A method of evaluating a cerebrovascular health of a patient includes causing a patient to exercise for an exercise duration at an exercise intensity, collecting cerebrovascular information from the patient during the exercise duration, collecting cardiovascular information from the patient during the exercise duration, correlating the cerebrovascular information to the cardiovascular information to create a correlated cerebrovascular curve, and determining a cerebrovascular health and viability for cerebrovascular therapy.