Arrangements described herein relate to a headset. The headset includes a device. The device includes a transducer configured to interact with a head of a subject. The headset further includes a manually-operated registration system configured to delineate a workspace of the transducer at the head of the subject.

A therapeutic ultrasound method configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion is described. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultrasound pulse. In some examples, the method may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment.

A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multi-channel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multi-modal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.

An ultrasonic diagnostic imaging system is described which utilizes one or more transducer arrays affixed to the head of a patient to diagnose and treat stroke victims. The transducer headset produces a two or three dimensional image of the vasculature inside the cranium, preferably assisted by a microbubble contrast agent. A vascular flow map is produced by the system which may be diagnosed for signs of a blood clot. If a blood clot is detected, a therapeutic beam is transmitted while the contrast agent is present to break up the blood clot by the disruption of microbubbles. The headset may also be used in a monitoring application to detect the recurrence of blood clots in a stroke victim.

A tool for facilitating medical diagnosis is disclosed herein, including an ultrasound device configured to collect ultrasound data from a patient, a display device, and a processing circuit configured to generate a cerebral blood flow velocity (CBFV) waveform based on the ultrasound data, determine morphology indicators identifying attributes of the CBFV waveform, and configure the display device to display the CBFV waveform and the morphology indicators.

A tool for facilitating medical diagnosis is disclosed herein, including an ultrasound device configured to collect ultrasound data from a patient, a display device, and a processing circuit configured to generate a cerebral blood flow velocity (CBFV) waveform based on the ultrasound data, determine morphology indicators identifying attributes of the CBFV waveform, and configure the display device to display the CBFV waveform and the morphology indicators.

A tool for facilitating medical diagnosis is disclosed herein, including an ultrasound device configured to collect ultrasound data from a patient, a display device, and a processing circuit configured to generate a cerebral blood flow velocity (CBFV) waveform based on the ultrasound data, determine morphology indicators identifying attributes of the CBFV waveform, and configure the display device to display the CBFV waveform and the morphology indicators.

A method for ultrasonic imaging a volume behind a barrier includes placing an array of elements of a probe adjacent the barrier. The local thickness and the sound speed in the barrier are estimated. A plurality of sub-apertures are defined in the array of elements, each sub-aperture defined by a different sub-set of adjacent ones of the array of elements. Ultrasonic waveforms are collected from each of the sub-apertures by focusing each sub-aperture approximately at the inner surface of the barrier. The ultrasonic waveforms through each of the sub-aperture elements are combined to generate a combined A-mode waveform. A profile of an inner surface of the barrier adjacent the probe is extracted based upon the combined A-mode waveforms. A correction is calculated based upon the profile of the inner surface. The volume behind the barrier is scanned using beamforming based upon the correction to generate an image of the volume.

A device is provided for diagnostic measurement by simultaneous multimodal analysis of a subject's head wherein the cerebral blood flow variations as well as the concentration level of oxygenation in the subject's blood are used to determine the presence and the pathophysiology of neurocognitive disorders, including the neurodegenerative disease referred to as Alzheimer's disease.