The present invention relates to a pulse generating circuit for an electrosurgical generator, for generating a waveform suitable for causing electroporation of biological tissue. The pulse generating circuit comprises a voltage source connectable to a load via a switching element, and an open circuit coaxial transmission line connected between the switching element and the voltage source to be charged by the voltage source when the switching element is in an OFF state and to be discharged when the switching element is in an ON state. The switching element comprises a plurality of series connected avalanche transistors, and a trigger pulse generator configured to generate a trigger pulse to activate the plurality of series connected avalanche transistors. Furthermore, the impedance of the coaxial transmission line is configured to match a sum of (i) the impedance the plurality of series connected avalanche transistors, and (ii) the impedance of the load.

A therapeutic apparatus for therapeutic ultrasonic treatment of a tissue region that contains a flowing liquid has at least one ultrasonic source and a control unit for activating the ultrasonic source in order to radiate ultrasonic pulses according to a pulse parameter set into the tissue region. The therapeutic apparatus has a measuring system configured to determine a flow velocity of the liquid and a focus control system configured to move a focus region of the ultrasonic pulse relative to the tissue region over a longitudinal portion. A movement direction of the focus region therein corresponds to a flow direction of the liquid and a movement velocity of the focus region corresponds to the flow velocity.

A motor-driven surgical cutting and fastening instrument that comprises an end effector, an electric motor, and a motor control circuit. The motor control circuit is for monitoring a parameter of the electric motor that is indicative of movement of a moveable member of the end effector, and for adjustably controlling the electric motor based on the monitored parameter to thereby adjustably control movement of the moveable member of the end effector during forward rotation of the electric motor.

Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.

A method for characterizing a state of an end effector of an ultrasonic device is disclosed. The ultrasonic device including an electromechanical ultrasonic system defined by a predetermined resonant frequency. The electromechanical ultrasonic system further including an ultrasonic transducer coupled to an ultrasonic blade. The method including applying, by an energy source, a power level to the ultrasonic transducer; measuring, by a control circuit coupled to a memory, an impedance value of the ultrasonic transducer; comparing, by the control circuit, the impedance value to a reference impedance value stored in the memory; classifying, by the control circuit, the impedance value based on the comparison; characterizing, by the control circuit, the state of the electromechanical ultrasonic system based on the classification of the impedance value; and adjusting, by the control circuit, the power level applied to the ultrasonic transducer based on the characterization of the state of the end effector.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

A surgical instrument comprising a shaft, an end effector, a housing, a drive assembly, and a manually-driven actuator is disclosed. The end effector comprises a first jaw and a second jaw rotatable relative to the first jaw between an open position and a clamped position. The housing comprises a rotary input movable by a motor. The drive assembly is operably engaged with the rotary input. The drive assembly is movable by the motor in a motorized mode of operation to transition the second jaw toward the clamped position. The drive assembly is movable in a non-motorized mode of operation by the manually-driven actuator to permit a transition of the second jaw toward the open position to release tissue between the first jaw and the second jaw.

According to an aspect, there is provided an apparatus for use with a treatment device for providing feedback to a user on a treatment operation performed on a body part of a subject, wherein the treatment device is configured to apply light pulses to skin of the body part to perform the treatment operation, wherein a light pulse applied to the skin treats an area of the skin. The apparatus comprises a processing unit configured to receive a first measurement signal from a first sensor, the first measurement signal comprising information about positions and/or movements of the treatment device over time; for a light pulse previously applied by the treatment device to the body part during the treatment operation, process the first measurement signal to estimate a previous treatment position as a position of the treatment device relative to the body part when the light pulse was generated; for the previously applied light pulse and based on the estimated previous treatment position, estimate a previous treatment area for the light pulse corresponding to the area of skin of the body part that the light pulse was applied to when the treatment device was at the previous treatment position; process the first measurement signal to estimate a current position of the treatment device relative to the body part; based on the estimated current position of the treatment device, estimate a current treatment area corresponding to an area of skin that the treatment device would apply a light pulse to while in the current position; and generate a feedback control signal for a feedback unit, wherein the feedback control signal is configured to cause the feedback unit to generate feedback indicating whether the current treatment area corresponds, or substantially corresponds, to a previous treatment area.

A generator, ultrasonic device, and method for controlling a temperature of an ultrasonic blade are disclosed. A control circuit coupled to a memory determines an actual resonant frequency of an ultrasonic electromechanical system comprising an ultrasonic transducer coupled to an ultrasonic blade by an ultrasonic waveguide. The actual resonant frequency is correlated to an actual temperature of the ultrasonic blade. The control circuit retrieves from the memory a reference resonant frequency of the ultrasonic electromechanical system. The reference resonant frequency is correlated to a reference temperature of the ultrasonic blade. The control circuit then infers the temperature of the ultrasonic blade based on the difference between the actual resonant frequency and the reference resonant frequency. The control circuit controls the temperature of the ultrasonic blade based on the inferred temperature.

An ultrasonic device may include an electromechanical system defined by a resonant frequency and further include an ultrasonic transducer coupled to an ultrasonic blade. The device may be composed of two or more components, one of which is reusable and one of which is disposable. A method of detecting a proper installation of the components may include determining a spectroscopy signature of the blade coupled to the transducer, comparing the signature to a reference signature, determining an installation state of the components based on the comparison, and controlling a delivery of power to the transducer based on the comparison. The method may include enabling an operation of the device when the installation state of components is proper. The method may further include disabling the device when the installation state is not proper and generating a warning. The warning may be visible, audible, or tactile.