A medical device, system and method for modifying a left atrial appendage (LAA). The medical device system includes a tether anchored within the LAA and one or more tissue growth members or occluders configured to be slid over the tether and lodged within the LAA. With this arrangement, a physician may close-off the LAA with a selective number of tissue growth members to meet the varying LAA sizes as determined from imaging information while conducting the procedure.

The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

A medical implant for a left atrial appendage may include a central member having an anchor at a distal end and a plurality of legs joined together at a joint coupled to the central member. The plurality of legs may be configured to expand from a delivery configuration to a deployed configuration. A medical implant may include a central shaft having an anchor at a distal end and a cup-shaped occluder fixed to a proximal end of the central shaft, the occluder being configured to expand from a delivery configuration to a deployed configuration and retard tissue ingrowth thereon. A medical implant system may include a delivery sheath, an implant having an expandable frame including a plurality of legs each having an anchor and a mesh having a plurality of openings therethrough attached to the frame, and a plurality of particles disposed within the delivery sheath.

Devices for approximating multiple tissue edges internal to a body are disclosed.

Devices for approximating multiple tissue edges internal to a body are disclosed.

Devices for approximating multiple tissue edges internal to a body are disclosed.

The present application discloses an occluder, including a distal disc, a waist portion, and a proximal disc which are formed in sequence. The proximal disc includes a proximal disc surface. A proximal bending area is formed at a circumference of the proximal disc surface and bent towards the distal disc, where the proximal bending area surrounds an edge of the distal disc, and a stabilizing wire is further threaded through a free end of the proximal bending area and may tighten the free end of the proximal bending area towards the waist portion.

An occlusion clip is disclosed herein. The occlusion clip comprises a resilient base strip including a plurality of base strip segments defining a hexagonal profile that represents an open state of the occlusion clip. A plurality of housing segments is provided on each of the base strip segments. A core element is disposed and extends within the housing segments defining a half of the hexagonal profile, wherein the core element is configured for linear movement within the housing segments. An actuator cable extends from each of the core elements, wherein in an actuated state, the core element is pulled via the actuator cable, and the pulling facilitates relative movement between the housing segments and the core elements causing the core element to make the housing segments collinear, thereby defining a closed configuration of the occlusion clip.

An occlusion device or plug having a proximal plug section and a distal plug section. The plug sections may each be shifted between an unexpanded configuration and an expanded configuration at the deployment site to occlude the deployment site. A tubular member such as a silicone tube may be used to form an occlusion device or plug shiftable or expandable into a desired configuration. An intermediate section between a proximal plug section and a distal plug section may be configured to be manipulated at least to shift at least one of the plug sections from an expanded configuration to an unexpanded configuration. A pair of stents may be coupled together via an intermediate section in such manner such that manipulation of the intermediate section causes at least one of the stents to shift from an expanded configuration to an unexpanded configuration.

A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold.