A surgical fastener applying apparatus includes an anvil half-section and a cartridge-receiving half-section including an elongated channel member having a pair of opposed openings defined through sidewalls thereof. A disposable assembly including a single use loading unit and a single use firing unit is configured to be releasably supported within the cartridge-receiving half-section. The disposable assembly includes a stationary housing for supporting the firing unit which includes a distal extension for supporting the single use loading unit. The stationary housing includes a pair of flared tabs configured to be releasably received within the openings of the cartridge-receiving half-section to releasably engage the disposable assembly within the cartridge-receiving half-section.

Described are devices and methods for medically sealing a perivalvular leak associated with implanted valves. For example, a bioresorbable tissue infiltratable sheet is provided for insertion through a perivalvular leak. A filament extending through the sheet is also provided which when pulled causes the sheet to gather around the filament on either side of the perivalvular leak. The gathered position of the sheet may be secured by a series of stops and/or use of a capping member.

The present invention relates to a Left atrial appendage occluder comprising an elastic closure disc. The left atrial appendage occluder also comprises an elastic fixing frame connected with the closure disc and located on one side of the closure disc. The fixing frame comprises a central end connected with the closure disc and a plurality of interconnected and bent struts, wherein at least one anchor is set near the end of at least one strut with the anchor pointing toward the closure disc. The left atrial appendage occluder has a stable structure, a good positioning and sealing effect on the cavity wall in the left atrial appendage, and it is easy to position repeatedly; it can also be recycled before separating from a conveyor. When in surgical operation, the left atrial appendage occluder can select the position area based on the actual shape and size of the patient's left atrial appendage, so the surgical risk is lowered.

A system to facilitate sealing a puncture of a vessel includes an implant having first and second expandable sections, and a delivery device that includes an inner tube and a circumscribing outer tube. The outer tube defines a first lumen configured to retain the implant, and a second lumen configured to channel fluid from the vessel through a distal opening proximal to the implant. A pusher circumscribed at least partially by the outer tube is configured to compress the implant to selectively expand the first and second expandable sections. The outer tube is selectively retractable relative to the inner tube such that the first expandable section remains substantially within the first lumen and the second expandable section is positioned outside of the first lumen. The outer tube is further selectively retractable relative to the inner tube such that the first expandable section is positioned outside of the first lumen.

Devices and methods for treating a sinus venosus atrial septal defect. A treatment device may have a tubular shape and may be configured to be arranged to provide a conduit between an upper right pulmonary vein (PV) and a left atrium (LA). The device may have a proximal portion comprising a flexible mesh configured to anchor within the LA, a distal portion comprising a flexible mesh configured to anchor within the target PV, and a central portion having a plurality of elongate parallel bars. A method for treating a sinus venosus atrial septal defect may include percutaneously advancing the device through the femoral vein and inferior vena cava (IVC), and into the right atrium (RA). The method may include creating a trans-septal opening, passing the device through the opening into the LA, and toward the upper right PV to treat the defect.

Catheter-based devices and methods for endoluminally accessing and occluding hollow anatomical structures are disclosed. Occlusion clips are contained in one or more needles that pierce opposing walls of the anatomical structure to deploy the clips externally of the structure. The clips then are drawn together to press the opposing anatomical walls together.

The present invention relates generally to a closure system for use in surgical procedures.

Devices and methods for occluding or promoting fluid flow through openings are disclosed. In one exemplary embodiment an occlusion device is provided having an expandable outer elongate tubular body, a guide member extending from a distal end of the outer body, and a slide tube disposed within the outer body, the proximal portions of the outer body and the slide tube being fixedly mated. The slide tube is configured to slide distally within the outer tubular body when the tubular body is expanded to form wings. A tether can be included as part of the device and it can be used to assist in positioning and locking a location of the device in an opening. Exemplary methods for delivering devices disclosed herein are also provided.

An occlusive medical implant for implantation within a left atrial appendage may include an expandable framework configured to self-expand from a collapsed configuration to an expanded configuration, and an occlusive element disposed on a proximal portion of the expandable framework. At least a portion of the expandable framework may be mechanically expandable from the expanded configuration to a securement configuration. When the occlusive medical implant is disposed within the left atrial appendage, the expandable framework exerts a first radial force on the left atrial appendage in the expanded configuration and the expandable framework exerts a second radial force on the left atrial appendage in the securement configuration. The second radial force is greater than the first radial force.

Among other things, methods and apparatus for inserting devices for closing a tissue opening are disclosed. An anchoring or sealing member has one or more stems and/or filaments that are offset from the center of the member, so that lateral adjustments or movements of the anchoring or sealing member do not uncover the opening, cause the anchoring or sealing member to stick through or pull through the opening. Embodiments including a valve adapted to accommodate a guide wire for addressing emergencies are also disclosed.