Systems, instruments, and methods are described in which an apparatus comprises a housing including a scalpet device. The scalpet device includes a scalpet array that includes scalpets arranged in a pattern. The scalpets are deployable from the housing to generate incised skin pixels at a target site. The housing is positioned and the scalpet array is deployed into tissue at the target site. Incised skin pixels are generated when the target site is a donor site, and skin defects are generated when the target site is a recipient site. The incised skin pixels are harvested.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

Probes for delivering ultrasonic energy and related methods. The probe includes a shank having a shaft coupling a proximal end to a distal end. The shank is configured to propagate ultrasonic energy from the proximal end to a tip of the distal end in a propagation direction parallel to a longitudinal axis disposed along a centerline of the shank. The tip may be positioned to substantially coincide with a displacement antinode position when the ultrasonic energy corresponds to odd integer multiples of a quarter wavelength of a resonance frequency. Multiple grooves within the shaft are configured to create multiple cavitation volumes in a medium proximate to the shank responsive to the ultrasonic energy. The multiple grooves include a second groove intervening between a first groove and the proximal end. The first groove is positioned at a distance of an integer multiple of a half-wavelength of the resonance frequency.

Systems and methods for treating cellulite including an apparatus that applies or a method involving separating septa to eliminate or reduce the appearance of cellulite. In one approach, an interventional tool is placed between tissue layers to engage and treat septa connecting tissue layers between which fat deposits are contained.

Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

A hand held instrument for harvesting a biopsy sample is provided. The instrument includes a housing, an annular blade on a distal end of said housing for cutting axially cutting a biopsy, a transverse blade unit for transversely cutting the biopsy, and a plunger unit positioned within the housing ejecting the biopsy sample away from inside the housing after said biopsy sample has been transversely cut.

The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

The invention relates to a skin treatment device comprising a housing (10) with a handle section (11), a disc-shaped skin treatment element (21), a drive mechanism incorporated in said housing and coupled to said skin treatment element for driving said skin treatment element into rotational movement about a rotational axis, wherein said skin treatment element has a first skin treatment surface (22) and a second skin treatment surface (25), said first skin treatment surface (22) being oriented axially with respect to said rotational axis, said second skin treatment surface (25) being oriented radially with respect to said rotational axis and extending along a circumference of the skin treatment element.

A hands-free foot care and callous removal device is provided, configured to enable insertion of a user's foot into the device to contact brush plates for hands-free cleaning and/or massaging of the foot and/or to enable the user to contact abrasive surfaces with the foot's top, sides, bottom, and/or heel for hands-free abrading of dead skin and/or callouses on the foot. A method of using the device for hands-free cleaning, massaging, or abrading the foot is also provided, particularly wherein the user has difficulty accessing surfaces of their feet due to a chronic condition such as arthritis, obesity, chronic back pain, or injury.