A method to orchestrate configurations of simulations based on digital twin models of modular plants such that the configurations of the model-based simulations are generated and deployed automatically, is proposed and based on a logical System Structure and Parameterization functionality including a Functional Mock-up Interface-functionality combined with a Functional Mock-up Unit-functionality to generate for distributed operational-technology-applications of the modular plants simulated model components including assignment rules for automation data captured due to automation of the plants and assigned to the distributed operational-technology-applications, and deploying the simulated model components on the distributed operational-technology-applications by using the SSP-functionality with Functional Mock-up Unit-functionalities as part of the FMI-functionality for the distributed operational-technology-applications and implementing for the distributed operational-technology-applications and as part of the FMI-functionality in a server-client-manner Remote Procedure Call-technology based Proxy-FMU-functionalities with Proxy-FMU-entities embedded in the SSP-functionality and corresponding Remote-Controlled-FMU-entities implemented on the distributed operational-technology-applications is provided.