A wire lock assembly for an access port of an elongate medical tube includes a body having an exterior surface, an interior surface, and a central opening disposed therethrough, an attachment mechanism disposed through the exterior surface of the body, the attachment mechanism having an open end and a closed end, at least one notch arranged on the body and positioned proximate to the central opening and at least one seal supported within the interior surface of the body in communication with the central opening, the seal comprising a passageway therethrough, where the interior surface of the body defines a non-linear pathway for securing one or more medical devices.

Cartridges and methods for ligation or dissection and ligation of tubular tissue structures are described. The cartridges and methods provide a means for efficient dissection and application of one or more ligatures by a single user using a single cartridge resulting in effective closure of a vessel or other tubular tissue structure by placement of a ligature at the desired location resulting in the desired tissue margin or stump.

Ring comprising: an outer belt (3) equipped with closing means (7) for closing the ring (1) around a duct (2); an inner chamber (4) that can be inflated and deflated; a flexible inflation/deflation tube (5);
wherein the lips have contact surfaces facing each other, the closing means comprising at least one perforation arranged on the contact surface of a first of the two lips and at least one protrusion protruding from the contact surface of a second of the two lips, the protrusion and the perforation being configured so that the protrusion is retained in the perforation by fitting, the fitting being selected to be released in the event of overpressure in the ring.

A novel catheter-based system which ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter positioned inside the left atrial appendage which may assist in locating the left atrial appendage and/or assist in the optimal placement of a ligature on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set a ligating element at the neck of the left atrial appendage.

Described here are devices, systems and methods for closing the left atrial appendage. Some of the methods described here utilize one or more guide members having alignment members to aid in positioning of a closure device. In general, these methods include advancing a first guide having a first alignment member into the left atrial appendage, advancing a second guide, having a second alignment member, into the pericardial space, aligning the first and second alignment members, advancing a left atrial appendage closure device into the pericardial space and adjacent to the left atrial appendage, and closing the left atrial appendage with the closure device. In these variations, the closure device typically has an elongate body having a proximal end and a distal end, and a closure element at least partially housed within the elongate body. The closure element comprises a loop defining a continuous aperture therethrough.

A ligating system having a ligating apparatus configured to attach to a distal end of a scope and to hold a ligating band thereon; an activating cord configured to extend down a working channel of the scope and attach to the ligating apparatus; and a line pulling assembly including: a central body; an attachment mechanism on the central body configured to attach the line pulling assembly to a proximal end of the scope; an access channel through the central body and in communication with the working channel of the scope, the access channel providing an open inlet to the working channel of the scope when the line pulling assembly is attached to the proximal end of the scope; and a winding mechanism attached to the central body, wherein the winding mechanism is configured to pull the activating cord proximally such that the ligating band is removed from the ligating apparatus.

An integral closure mechanism is described to be used for implantable cuffs of tubular shapes. This mechanism relates to cuffs used to surround internal organ or tissue in animals and human for specific clinical applications or for evaluation purposes in biomedical research. The closure mechanism is designed to provide a safe and reliable way in keeping the cuff in its original dimension around biological tissue, and to assist in surgical implantation by introducing a convenient and less time-consuming method to secure the cuff at the surgical site. To eliminate distortion of the implantable cuff by having an integral closure mechanism, the underlying body tissue is better protected from damages caused by compression of the cuff and from connective tissue overgrowing at the distorted sites. Thus, therapeutic attempts by using implantable cuffs may reach their desired potential in various applications.

A curved-head hemorrhoid banding device may include an inner cylinder curved at one end for sucking the hemorrhoid tissue into the device for banding. The device also may include a curved outer cylinder for releasing a rubber band, a straight barrel for pushing the curved outer cylinder to release the rubber band, an airtight plunger (or operator handle), and a handle for generating negative pressure. The banding device may provide tighter contact with hemorrhoid tissues and thus may provide better suction of hemorrhoid feeding vessels and adjacent rectal mucosal tissue. When being manipulated into contact with the internal hemorrhoid feeding vessel position, the device may maximally fit the anatomic configuration of the rectum, causing less discomfort to the patient during banding and after the procedure. The banding device may be disposable and designed for single-handed use.

An arthroscopic bleeding control device shows a static absorptive and hemostatic effect against hemorrhage in an articular cavity that can be exposed by an arthroscopy part, and includes a hemostatic block configured to be inserted in the articular cavity through the arthroscopy part, and a hemostatic unit including a lead line extending from the hemostatic block to protrude outside through the arthroscopy part, in which the hemostatic block is formed by winding or folding a hemostatic band elongated in a longitudinal direction and then compressed in a thickness direction at least into a reference thickness for insertion into the articular cavity, so the hemostatic block can be expanded at least in the thickness direction by hemorrhage in the articular cavity, and when the lead line is pulled, the hemostatic band is unwound or unfolded from the expanding hemostatic block, so the hemostatic block is taken out of the articular cavity.

Disclosed are devices for pericardial access to the heart, including direct access to the left atrium. In certain embodiments, the device may comprise a device and/or an atrial appendage (AA) portal having a configuration such that the distal end of the device and/or the portal can access an atrial appendage while the proximal end of the device and/or portal can extend to outside of the subject. The devices and methods may also include a pericardial portal for emplacement of the device and/or the AA portal. Also, methods for using such devices and/or AA portals and pericardial portals to perform surgery on the heart, and systems (e.g., kits) comprising these devices and/or portals in combination with other therapeutic devices are disclosed.