A medical device, configured to perform an endovascular therapy, e.g., thrombectomy, can comprise an elongate manipulation member having a first connection member proximate a distal end of the elongate manipulation member, and an intervention member having a second connection member proximate a proximal end of the intervention member. The second connection member can be connected to the first connection member such that the first connection member can rotate relative to the second connection member.

Aspects of a device are described. One aspect is a device comprising: a housing having a first portion engageable with a scope, and a second portion engageable with a handle of a retrieval device; a platform that is movable relative to the housing, and engageable with a slider of the retrieval device; and a link assembly that is coupled the housing and the platform, and operable to move the platform and slider relative to the housing and handle. Aspects of related devices and systems also are described.

A lead engagement device is configured to be positioned in a lead lumen. The lead engagement device includes a hypotube. The hypotube includes a wall having an inner surface defining an inner lumen and an outer surface. The wall defines a longitudinal axis of the hypotube. A plurality of lead engagement fingers extend outwardly and proximally from the outer surface at acute angles, and planes in which the acute angles are disposed extend diagonally relative to the longitudinal axis. The plurality of lead engagement fingers are configured to translate relative to the lead and permit relative motion between the lead engagement device and the lead when applying a first force to the lead engagement device. The plurality of lead engagement fingers are configured to engage the lead and inhibit relative motion between the lead engagement device and the lead when applying an opposite second force to the lead engagement device.

The present invention pertains to a thrombectomy device comprising a cylindrical proximal portion and one or more radiopaque segments. The cylindrical proximal portion forms a stent frame having an outer lattice network of an outer plurality of interconnecting segments. The outer plurality of interconnecting segments are configured to exert a radial force against an inner wall of a blood vessel. The radiopaque segment is formed from a plurality of radiopaque wires extending from the outer stent frame to a central axis of the thrombectomy device along a length of the stent frame. The radiopaque segment converges to a tip along with the central axis.

Intraluminal devices and methods for removing an obstruction from a blood vessel using an intraluminal device are provided. The intraluminal device can include a flexible shaft and an expandable wire mesh structure extending from the flexible shaft, the wire mesh structure including at least one first expandable section having a first wire arrangement pattern and at least one second expandable section having a second wire arrangement pattern different from the first wire arrangement pattern. In addition, interstices in the at least one second expandable section.

A clot encasement and removal device for removing a vascular obstruction is disclosed. The encasement device comprises proximal and distal capture members and a central stabilizer. The central stabilizer provides several points of contact for interacting with and manipulating an intravascular obstruction. The central stabilizer may be coupled to the distal capture member, allowing the central stabilizer and distal capture member to be manipulated in unison. The central stabilizer may reside on a distinct delivery wire, enabling independent control of proximal and distal capture members and the central stabilizer. The proximal capture member may comprise a furrowed delivery wire to enable retraction of at least a portion of the central stabilizer within the proximal capture member.

A device including a clot engaging device having a collapsed delivery configuration and an expanded deployment configuration. The device can include a plurality of struts defining a plurality of cells; a seam extending along at least a portion of a length of a distal end of the clot engaging device, wherein the seam comprises a pattern configured for gripping a clot and extends between cells of the plurality of cells; and a distal scaffolding region being distally tapered, wherein the distal scaffolding region comprises cells smaller than cells of a remainder of the clot engaging device.

Snare device with anti-skewing. In one embodiment, the snare device includes a core-wire. The core-wire is made of a superelastic material and includes a proximal portion of greater cross-sectional area and a distal portion of lesser cross-sectional area. The distal portion includes a looped shape in a relaxed state. A flexible coil is mounted around the core-wire and is straight in a compressed state. The distal ends of the core-wire and the coil are coupled together. The proximal end of the core-wire is coupled to a handle of an actuator, and the proximal end of the coil is coupled to a slide of an actuator, the slide being slidably mounted on the handle. The tensile strength of the coil multiplied by the cross-sectional area of the coil is greater than the upper plateau stress of the core-wire distal portion multiplied by the cross-sectional area of the core-wire distal portion.

A medical device for removal of an occlusion from a vessel in a patient’s body. The retrieval device having a retriever sub-system and an aspiration sub-system. The retriever sub-system having a delivery catheter and an elongated delivery member that includes proximal and distal expandable elements, the proximal element being removably engaged to the elongated delivery member and the distal element being fixed to the elongated delivery member. The proximal element adapted to move axially along the elongated delivery member in a distal direction toward the distal element when the proximal element is released from the elongated delivery member, whereby, when the proximal element is disposed on a distal side of the vessel occlusion and the distal element is disposed on a proximal side of the occlusion, the proximal and distal elements surround, isolate and contain the occlusion between the proximal and distal elements at the vessel occlusion site. The medical device also includes means for delivering a pharmacological agent composition to the vessel occlusion site during and after the occlusion extraction, the pharmacological agent composition adapted to at least partially lyse and/or disassociate the occlusion from the vessel wall or ameliorate and/or facilitate amelioration of tissue damage to an endothelial luminal wall of an obstructed vessel in vivo and/or enhance the flow rate of blood through the vessel. The aspiration sub-system being in communication with the retriever sub-system and adapted to remove at least a portion of the occlusion from the vessel.

Methods and apparatus are provided to facilitate the minimally invasive removal of tissue biopsies and to facilitate the direct approach to anesthetizing the chest wall, in accordance with embodiments of the present invention. A pull-type cutting device 1 comprises two coaxially nested tubes, each extending from a proximal end 21 to a distal end 22. The first tube 61 defines a guide wire lumen 23 for slidingly receiving a guide wire. The second tube 63 extends over the first tube 60 and coupled thereto at the distal end 22 defining an expandable portion 13 adjacent the distal end 22. The second tube 63 defines an inflation lumen 25 extending from the shaft proximal end 21 to the expandable portion 13. The inflation lumen 25 communicates inflation fluid from the proximal end 21 to the expandable portion 13 so as to inflate and deploy the expandable portion 13. Disposed adjacent the shaft distal end 22 is a cutting head 10 comprising the expandable portion 13 having a cutting portion 11 distal from the shaft distal end 22.