A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

A vaginal device is described. A conformable vaginal insert is shaped for insertion into a vaginal cavity of a female human. A contact point is configured to change a shape of the insert. A sensor is configured to measure and to relay characteristics of the vaginal cavity and the surrounding and supportive structures of the vaginal cavity. A processor is configured to control the contact point to adjust the shape of the insert, generate a treatment for the vaginal cavity and the surrounding structures of the vaginal cavity and the supportive structures of the vaginal cavity comprising a vaginal cavity profile generated from the measured characteristics, store the measured characteristics and the vaginal cavity profile, and based on the stored measured characteristics and the stored vaginal cavity profile, automatically modify the shape of the insert by control of the contact point to provide the treatment to the vaginal cavity.

Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

The invention relates to a medical device intended to be inserted into the lumen of a cavity of the human or animal body or in the lumen of a blood vessel. The invention is characterised in that said device comprises a probe (5) suitable for delivering a treatment by the endovenous route, and, at the terminal end thereof, a hooked flexible tip (1), wherein the angle α formed between the extension of the end portion of the probe (5) and the extension of the end portion of the tip (1) is strictly less than +90°, said tip comprising means (3) for delivering a treatment. The invention is particularly applicable to the treatment of varicose veins, reticular veins and spider veins.

A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle. The control circuitry can be further configured to operate the one or more pressurizing elements to generate coordinated pressure modifications in the left atrium, and optionally the pulmonary artery.

Devices, systems and methods are provided for deployment of one or more functional devices, such as therapeutic and/or diagnostic medical devices and/or positioning devices, at various locations relative to a defined operative path. The devices, systems, and methods can include a guide system and a positioning element. The guide system defines the operative path when deployed within a patient's body. The positioning element cooperates with the guide system to define one or more positions relative the defined operative path from which the one or more functional devices are deployed. The present inventions allow for the accurate and reliable placement of the one or more functional devices at the one or more positions relative the operative path. In one embodiment, the functional device is an ablation device adapted to ablate cardiac tissue for the treatment of cardiac arrhythmias, such as atrial fibrillation.

The present invention relates to an ablation catheter (1) for the ablation of tissues comprising: a telescopic tubular body (4) in turn comprising an external tubular body (4a) and an internal tubular body (4b) concentric with each other, and a rod-like guiding element (5) at least partly housed in the internal tubular body (4b) with at least one free end (5a) protruding from the internal tubular body (4b) in correspondence with a distal end of the telescopic body (4); a positioning head (2, 2″, 2′″, 2°, 2*, 2{circumflex over ( )}) and an ablation head (3) in correspondence with the distal end of the telescopic body (4), the positioning head (2,2″,2″′,2′,2*,2{circumflex over ( )}) being situated in the proximity of the free end (5a) of the rod-like guide, and the ablation head (3) in the proximity of the positioning head (2, 2″, 2″′, 2°, 2*, 2{circumflex over ( )}), in a remote position with respect to the free end (5a); a control handpiece at a proximal end of the telescopic body (4) coupled with the guiding element (5), the ablation head (3), the positioning head (2, 2″, 2′″, 2°, 2*, 2{circumflex over ( )}) and the telescopic tubular body (4); wherein the ablation head (3) comprises at least two ablation elements or petals (3a) that can be moved from a rest position in which they are housed in the external tubular body (4a) and an operating position in which they protrude from the external tubular body (4a) like a petal; wherein each of the ablation elements or petals (3a) comprises: a continuous ablation electrode (3b) which extends without interruption over a circumferential peripheral portion of each petal (3a), substantially along an arc of circumference having a longitudinal axis of the rod-like guiding element (5) as its centre; two side portions (3c) of the petal (3a), each connected to an end of the ablation electrode (3b), in correspondence with a curved section, the side portions (3c) and the ablation electrode (3b) being integral with each other, formed by means of the same folded metallic conductor, each ablation petal (3a) being separate and distinct from another ablation petal (3a) of the ablation head, all the ablation petals (3a) of the ablation head being separately connected to a distinct electr

A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

The present invention, in some embodiments thereof, relates to a devices and methods for intravascular denervation and assessment thereof and, more particularly, but not exclusively, to devices and methods for renal denervation. Some embodiments of the invention relate to an intravascular catheter configured for ultrasonic ablation of the tissue, comprising a plurality of piezoelectric transceivers. In some embodiments, an intravascular distancing device is provided, the device adapted for obtaining at least a minimal distance between an ultrasound emitting element and a tissue, such as the blood vessel wall. Some embodiments of the invention relate to assessment of renal sympathetic denervation (RSD) treatment effectiveness. Some embodiments of the invention relate to processing echo of signals, such as processing of signals to characterize physical and/or mechanical properties of the blood vessel.