A medical device includes a handle assembly and a flexible elongate member extending distally from the handle assembly. The elongate member includes a first lumen extending from the distal end of the elongate member at least partially along the elongate member toward the proximal end of the elongate member. The first lumen is configured to accept a guidewire. The elongate shaft includes a second lumen extending through at least a portion of the elongate member. A cutting wire extends through the second lumen. A distal end of the cutting wire is connected to the distal end of the elongate member, and a portion of the cutting wire extends external to the outer surface of the elongate member proximal of the distal end. An expandable scaffold is disposed at the distal portion of the elongate member. An actuator is configured to actuate the expandable scaffold between a contracted, delivery configuration and a radially expanded, deployed configuration.

A medical device may comprise: a handle including an actuator; a shaft extending from the handle, wherein the shaft includes a wire lumen extending longitudinally through the shaft; and a wire positioned within the wire lumen and extending from the handle to a distal end of the shaft. A distal portion of the wire extends (i) out of a rear-side opening of the shaft and (ii) into a tip-side opening of the shaft such that an exposed portion of the wire is outside of the shaft between the rear-side opening and the tip-side opening; and a distal end of the wire is coupled to the shaft.

Provided herein are catheter devices, systems, and methods to ablate a tissue location. The devises, systems, and methods disclosed herein include ablation systems including a catheter system with inner and outer shafts that deliver an ablation medium (e.g., a cryogenic ablation medium) to a body lumen and evacuate the ablation medium from the body lumen. In some embodiments, devices, systems, and methods disclose herein include expandable structures that facilitate in positioning of nozzles and/or evacuation of ablation medium from a body lumen.

An access device used with an endoscope includes an access pipe configured to be inserted into a sheath of the endoscope, a piercer disposed on a distal end portion of the access pipe and configured to pierce into a hollow organ through a digestive tract of a patient, and a treatment tool configured to be inserted into the access pipe and to be introduced into the hollow organ by the piercer. The access device is switchable between a first configuration and a second configuration. In the first configuration, a piercing function of the piercer is switched on, so that the piercer pierces the digestive tract and the hollow organ to enter into an interior of the hollow organ, and in the second configuration, the piercing function of the piercer is switched off, the piercer is kept connected to the interior of the hollow organ.

An access device used with an endoscope includes an access pipe configured to be inserted into a sheath of the endoscope, a piercer disposed on a distal end portion of the access pipe and configured to pierce into a hollow organ through a digestive tract of a patient, and a treatment tool configured to be inserted into the access pipe and to be introduced into the hollow organ by the piercer. The access device is switchable between a first configuration and a second configuration. In the first configuration, a piercing function of the piercer is switched on, so that the piercer pierces the digestive tract and the hollow organ to enter into an interior of the hollow organ, and in the second configuration, the piercing function of the piercer is switched off, the piercer is kept connected to the interior of the hollow organ.