A device for providing a cryotherapy ablation treatment includes a piping assembly and a snow horn adapted to create a spray of snow from a pressurized source of a low-temperature liquid, a tubular applicator for collecting a mass of snow at a prescribed density that is sufficient to allow the mass to serve as the needed, low temperature, thermal reservoir for the device after the applicator's distal end has been disconnected from the snow horn end so that it can to be used during the treatment process, and an applicator tip adapted to allow it to connect to the applicator's distal end and be used to treat those specific locations which are to receive this treatment.

A method of selectively killing cancer cells uses a low-temperature plasma jet device. When cancer cells are simultaneously treated with ATR and PARP-1 inhibitors, followed by synchronization of a circadian rhythm and treatment with low-temperature atmospheric-pressure plasma, cancer cell death may be maximized about ten-fold or more compared to when treated with existing low-temperature atmospheric-pressure plasma alone, and thus this method may be usefully used as a future tumor treatment method.

An arthroscopic tissue resecting probe includes an elongated shaft having outer and inner sleeves which are formed from an electrically conductive material extending about an axis to a working end. Outer and inner resecting windows are formed in the sleeves in the working end. The working end includes a ceramic body having a collar portion extending fully around a region of the outer sleeve proximal to outer resecting window. A radiofrequency (RF) electrode is disposed on an outer surface of the ceramic body and is spaced-apart from the outer resecting window.

Disclosed herein is a system for treating skin and/or nails with cold plasma. The system includes a discharge device, which includes a handle and an applicator mounted thereon, and control infrastructure, which includes a waveform generator. The applicator includes an elongated tube housing therein a cathode. The handle includes a flyback amplifier. The waveform generator is configured to induce the flyback amplifier to establish a voltage at the cathode. The voltage produced by the flyback amplifier is configured to allow generating a self-sustaining Townsend avalanche when a distal end of the tube is positioned sufficiently near a target site on a skin surface or a nail of a subject, such as to produce a cold plasma discharge directed at the target site and having an average power between about 0.1 μW and about 10 μW, so that the target site is not heated.

An ultrapolar electrosurgery blade and an ultrapolar electrosurgery blade assembly. The ultrapolar electrosurgery blade includes top and bottom thin elongated conductive members in vertical alignment and spaced apart from one another along their lengths where each of the top and bottom thin elongated conductive members includes opposing planar sides, a sharp cutting end, and an opposite non-cutting end, and a non-conductive coating covering both opposing sides of the top and bottom thin elongated conductive members and the space located between them where the cutting ends of the elongated conductive members and their opposite non-cutting ends remain exposed. The ultrapolar electrosurgery blade assembly of the present invention having argon beam capability further includes a non-conductive tube member having a hollow tubular shaped opening contained therein and a slot positioned over the top of the ultrapolar electrosurgery blade and a conductive hollow tubular member contained within at least a portion of the non-conductive tube member.

A catheter system (100) for placement within a treatment site (106) at a vessel wall (208A) or a heart valve includes an energy source (124), a balloon (104), an energy guide (122A), and a tissue identification system (142). The energy source (124) generates energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The tissue identification system (142) is configured to spectroscopically analyze tissue within the treatment site (106). A method for treating a treatment site (106) within or adjacent to a vessel wall (208A) or a heart valve can utilize any of the catheter systems (100) described herein.

A plasma generator is described comprising an elongate member having a distal end, a proximal end, and a lumen extending therethrough, the proximal end configured to be connectable to a source of an inert gas, a plasma generation tip disposed at the distal end of the elongate member, the plasma generation tip configured to be in electrical communication with a power source, and an activation switch configured to control generation of plasma at the plasma generation tip, wherein the plasma generator is configured to be operably connectable to a medical device.

An array of non-thermal plasma emitters is controlled to emit plasma based on application of an electric current at desired frequencies and a controlled power level. A power supply for an array controller includes a transformer that operates at the resonant frequency of the combined capacitance of the array and the cable connecting the array to the power supply. The power into the array is monitored by the controller and can be adjusted by the user. The controller monitors reflected power characteristics, such as harmonics of the alternating current, to determine initiation voltage of the plasma and/or resonant frequency plasma emitters. The array of non-thermal plasma emitters may be used in therapeutic, diagnostic, and/or medical sanitization applications, including where a non-thermal plasma treatment regimen is prescribed.

An electrosurgical wand is disclosed for treating a plurality of tissues at a variety of tissue locations. The electrosurgical wand includes a handle on a proximal end and an elongate shaft with a combination active electrode at the distal end. The combination active electrode includes with a blade and screen portion; the blade portion extending along and laterally from the wand longitudinal axis, forming a dissecting tip. The screen portion extends from the blade portion at an obtuse angle and has at least one aspiration aperture through it. The wand also includes a second and third electrode, proximally spaced from the combination active electrode. The second electrode spans a portion of an outside surface of the wand adjacent the blade portion, while the third electrode spans a portion of the outside surface of the wand opposite the second electrode.

Systems, devices, and methods involve ablation of tissue to treat rhinitis and/or other nasal conditions. Implementations allow treatment of tissue in the confined space of the nasal cavity. Additionally, implementations allow targeted treatment tissue to be ablated, while protecting other non-treatment tissue from unintentional collateral effects that might be produced by the ablation. According to an example implementation, an approach for treating a nasal condition includes advancing a probe into a nasal cavity, the probe including a shaft and a cryotherapy element coupled to the shaft. The approach also includes cryogenically cooling a target treatment site with the cryotherapy element to treat at least one nasal nerve. Additionally, the approach includes transmitting a focused ultrasound beam to a target heating site to increase a temperature tissue at the target heating site.