An irreversible electroporation (IRE) includes setting an initial IRE protocol for applying IRE pulses by electrodes of a catheter placed in contact with tissue in an organ. A notification is issued to a user upon determining that the initial IRE protocol is expected to cause bubbles in blood. In response to the notification, user input is received from the user, that selects between the initial IRE protocol and an alternative protocol that is not expected to cause the bubbles. The IRE pulses are applied according to the initial IRE protocol or the alternative IRE protocol, depending on the user input.

A cryogenic medical device is disclosed for use in minimally invasive surgical procedures. Various configurations of cryoprobes are designed in combination with a clamp to form a cryoclamp for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is an integrated cryoablation probe with a hinged clamp that allows for single entry into the chest cavity through a thorascopic port, by surgical or other means. The integrated cryoablation probe allows for the clamping of tissue as well as freezing with a single device. The clamp acts as an outer sheath so that when closed, directional freezing of the cryoprobe is achieved on the opposing probe surface away from the clamp or on an internal surface that is between the clamp. The cryoclamp may be a removable attachment or integrated into the unitary device.

A medical system may include: a medical device including an elongate shaft configured to access a treatment site within a patient and a handle coupled to a proximal end of the elongate shaft; a laser device including an elongate tubular member configured for insertion through a working lumen of the medical device, the elongate tubular member including a cooling channel and a laser fiber extending distally within the cooling channel; and a fluid management system including an inflow pump configured to pump fluid from a first fluid supply source through the elongate shaft to the treatment site, a cooling pump configured to pump fluid from a second fluid supply source through the cooling channel, and a controller configured to control the inflow pump and the cooling pump.

A heating treatment apparatus to treat a living tissue by heating the living tissue includes a first holding member and a second holding member, a first heat generating element provided on the first holding member, a second heat generating element provided on the second holding member, a power supply unit supplying electric power to cause the first heat generating element and the second heat generating element to generate heat, and a control unit controlling operations of the power supply unit. The control unit switches a mode between a first mode and a second mode during treatment of the living tissue. Temperatures of the first heat generating element and the second heat generating element are controlled to the same temperature in the first mode and to different temperatures in the second mode.

A balloon for renal nerve modulation is disclosed. The balloon may include a polymer material forming a balloon wall having an outer surface and flexible circuits comprising a base selectively adhered to the exterior surface of the balloon wall. Adhesive is selectively applied to the outer surface of the balloon, to the flexible circuit or to both such that the adhesive is selectively deposited on the at least a portion of the at least two pads or on the at least a portion of the at least two pads and to a portion of the distal spline. The portion of the at least two pads or the portion of the at least two pads and a portion of the distal spline are adhered to the outer surface of the balloon and a remainder of the flexible circuit moves freely with respect to the outer surface of the balloon.

A portable electrosurgical device (ESD) has a housing, a probe connected to the housing and a heating element connected to the probe for destroying human tissue. The heating element is detachable from the probe and/or the probe with heating element can be detachable from the housing. The user can set a drive signal's electrical characteristics, such as operating frequency, duty cycle, peak voltage and the like for a customized drive signal formed in the ESD based on the heating element used. Memory storage allows for storage of inputted data from a keyboard, downloaded reference documents and information off the Internet from an Ethernet connector that can be displayed for reference on a screen of the ESD. Another even more compact ESD is an integral one-piece portable device having a type of pistol hand-held grip, dis-connectable probe, and a rechargeable, removable battery in the handle provides approximately 30, one-minute treatments on a single battery charge.

The present invention relates to an RF treatment apparatus controlling the RF energy so that the target tissue is maintained within a range of a treatment temperature if the target tissue is determined to have reached the treatment temperature based on the impedance, a method of controlling the RF treatment apparatus, and a skin treatment method using RF energy. The RF treatment apparatus, the method of controlling the RF treatment apparatus and the skin treatment method using RF energy according to the present invention have an effect in that they can improve the accuracy and efficiency of treatment because whether a target tissue corresponds to a treatment temperature is determined based on impedance of the tissue and the volume of the target tissue corresponding to the treatment temperature can be maximized while maintaining the target tissue to the treatment temperature for a predetermined time.

The present invention relates to an RF treatment apparatus, the method of controlling the RF treatment apparatus and the skin treatment method using RF energy according to the present invention have an effect in that they can improve the accuracy and efficiency of treatment because whether a target tissue corresponds to a treatment temperature is determined based on impedance of the tissue and the volume of the target tissue corresponding to the treatment temperature can be maximized while maintaining the target tissue to the treatment temperature for a predetermined time.

The present disclosure relates to a method and an apparatus for generating a laser pulse sequence for application to a predetermined target tissue. Means are provided for setting a cumulative fluence F.sub.s of the laser pulse sequence. Means are provided for determining a duration of the laser pulse sequence as a function of the cumulative fluence F.sub.s such that the predetermined target tissue is heated to a final temperature that is within a predetermined range.

A method of treating tissue includes positioning a probe in proximity to tissue, reducing a temperature of the tissue such that a temperature of a portion of the tissue that is closer to the probe is less than a temperature of a portion of the tissue that is farther from the probe, and raising a temperature of the tissue such that the temperature of the portion of the tissue that is closer to the probe increases at a faster rate than the temperature of the portion of the tissue farther from the probe.