An integrated system for increasing skin rejuvenation of a region of a patient's skin and treating subcutaneous fat associated with the region is provided. The system includes at least one first applicator having one or more RF electrodes adapted to be placed on the region of the patient's skin without penetrating the skin. At least one of said RF electrodes is configured to apply RF energy to the region of the patient's skin to heat up to a temperature in a specified temperature range. The system also includes at least one second applicator, in communication with an optical system. The optical system includes at least one laser source and is adapted to provide homogeneous illumination to the skin surface to effect at least one target tissue at a given depth range and power density range.

A catheter ablation system includes: a catheter probe having distal end including: a temperature sensor; a plurality of irrigation holes; and an ablating electrode; a radiofrequency (RF) heating controller coupled to the catheter probe and configured to supply RF energy to the ablating electrode to control the ablating electrode to emit heat at a target power; an irrigation controller coupled to the catheter probe and configured to supply an irrigation fluid at a continuously adjustable irrigation flow rate through the catheter probe to exit through the irrigation holes; and an operating console having a processor and memory, the memory storing instructions that, when executed by the processor, cause the processor to control the irrigation controller to set the irrigation flow rate based on the target power and a target average temperature.

A controller for a cooled radiofrequency ablation system is configured to sequentially activate a plurality of pump assemblies with a pump activation time delay between the activation of each of the plurality of pump assemblies, measure a temperature drop delay time for each of a plurality of cooled radiofrequency ablation probes, map each respective pump assembly of the plurality of pump assemblies to a corresponding cooled radiofrequency ablation probe of the plurality of cooled radiofrequency ablation probes based on the temperature drop delay time and an activation time of each of the plurality of pump assemblies, and confirm the mapping of each respective pump assembly to the corresponding cooled radiofrequency ablation probe by comparing, for each of the plurality of cooled radiofrequency probes, the measured temperature drop delay time to an expected temperature drop delay time.

An ablation probe tip 100 having a shaft 102 with an insertion end 104 and an annular aperture 120 near the insertion end 104. A center of ablation 124 is located within the shaft 102 and surrounded by the annular aperture shaft 102. The ablation probe tip 100 may be part of an ablation probe system 50 that includes an ablation source 60 that provides ablation means 62 to the ablation probe tip 100. The center of ablation 124 is a focal region from which the ablation means 62 radiates through the annular aperture 120 to form an ablation zone 150, 160, 170. The system 50 has at least one intra-operative control selected from the group of: ablation zone positioning control, ablation zone shaping control, ablation center control, ablation zone temperature control, guided ablation volume/diameter control, and power loading control.

A medical device, including: a cooling system; a heating system; and an applicator including a cold base operationally coupled to the cooling system and a heating element operationally coupled to the heating system, and an applicator head collocated with the cold base and the heating element and adapted for applying a combination of heat and cold to a target area such as target tissue.

A cooled radiofrequency ablation system and method are provided. In particular, a method to map active radiofrequency channels to respective pump assemblies for cooled radiofrequency ablation is provided. The system includes a pump system having a plurality of pump assemblies, a radiofrequency generator unit, and a plurality of cooled radiofrequency probes, wherein each cooled radiofrequency probe comprises a cable-tubing assembly having a radiofrequency cable connected to the radiofrequency generator unit and fluid tubing in communication with a pump assembly and connected to a cooling fluid source. Each pump assembly of the plurality of pump assemblies is activated individually in sequence. The system and method map each cooled radiofrequency probe to a respective pump assembly connected thereto by measuring a temperature drop delay time at the tip of each probe. The system and method can further detect the presence of multiple probes daisy-chained to a single pump assembly.

Methods and systems are disclosed for removing a tattoo from a subject's skin by application of a cold plasma that is delivered via a liquid-gas mixture. The plasma can be delivered in the form of gas bubbles, in which at least a portion of gas is in the form of a plasma.

A cryoballoon control device (2), catheter system and temperature display method are disclosed. The control device (2) acquires a plurality of balloon circumference temperature values obtained by circumference temperature sensors (4) circumferentially disposed on a cryoballoon (1) and a balloon center temperature value obtained from a center temperature sensor (5) disposed at a center of the cryoballoon (1) and, automatically adjusts a flow rate of a coolant introduced into the cryoballoon (1) based on a comparison between a preset balloon temperature value and a comparative temperature value, to enable a temperature adjustment to the cryoballoon (1), wherein the comparative temperature value is the balloon center temperature value, any one of the balloon circumference temperature values, or a computational temperature value derived by a predefined algorithm from the plurality of balloon circumference temperature values. The cryoballoon catheter system is configured to display, on the display device (3), a plurality of balloon circumference temperature representation graphs surrounding a balloon center temperature representation graph, wherein when one of the balloon circumference temperature values exceeds a first predetermined threshold range, a corresponding one of the balloon circumference temperature representation graphs indicates a first alert condition which prompts an operator to adjust temperature of the cryoballoon (1).

A high temperature cryosurgery system and method of operation comprising a refrigeration assembly, a cryoprobe and a refrigerant wherein the cryoprobe and the refrigeration assembly are fluidly coupled in a closed loop configured to cycle the refrigerant in a fluid state from the refrigeration assembly to the cryoprobe and further configured to cycle the refrigerant in a vapor state from the cryoprobe to the refrigeration assembly. A method for treating cancer tumors and metastatic cancer cells by disrupting the tumor by sequentially or concurrently administering an ablative energy in combination with immunomodulation and/or pharmacological application, in one or more cycles, where the physical disruption is applied at levels sufficient to create the abscopal effect. That effect is generated by stimulating the immune cells in the microenvironment. The tumor is treated in a way permitting the remaining cells or elements in the tumor microenvironment to exert net immune stimulation with also long-term memory cells to fight subsequent appearing tumor in the future. Adding immune modulators injected in situ systemically or embedded in slow releasing means locally or systemically will boost the immune response to the cancer.

Systems and methods for the use of cooling to trigger desirable effects of increased vasculature and/or development of new collagen in biological tissue are provided. In particular, the systems and methods provide a cooling treatment system configured to provide bulk or fractionated cooling at either at ablative temperatures or intermediary remodeling temperatures to promote tissue remodeling by inducing increased vasculature and/or the formation of new collagen.