This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.

Systems, devices, and methods for electroporation ablation therapy are disclosed, with a protection device for isolating electronic circuitry, devices, and/or other components from a set of electrodes during a cardiac ablation procedure. A system can include a first set of electrodes disposable near cardiac tissue of a heart and a second set of electrodes disposable in contact with patient anatomy. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the first set of electrodes and configured to repeatedly deliver the pulse waveform to the first set of electrodes. The system can further include a protection device configured to selectively couple and decouple an electronic device to the second set of electrodes.

A method of operating a modular surgical system including a control module, a first surgical module, and a second surgical module is disclosed. The method includes detachably connecting the first surgical module to the control module by stacking the first surgical module with the control module in a stack configuration, detachably connecting the second surgical module to the first surgical module by stacking the second surgical module with the control module and the first surgical module in the stack configuration, powering up the modular surgical system, and monitoring distribution of power from a power supply of the control module to the first surgical module and the second surgical module.

An electrosurgical system including or connected to an output circuitry comprising an electrosurgical device and an electrical cable is modelled during a cable interrogation phase using a transfer matrix in order to determine a leakage capacitance in the electrosurgical system. After the leakage capacitance is assigned or set to a virtual capacitor in the transfer matrix, an output parameter of the electrosurgical system, such as output voltage, output current, output impedance or output electrical power, may be determined by applying an actual input voltage to the output circuitry and measuring a resulting input current, and multiplying the input voltage and measured current by the transfer matrix.

A method for medical treatment includes providing a probe configured for insertion into a heart of a living subject and comprising at least one probe electrode configured to contact myocardial tissue in the heart. At least one body-surface electrode is configured to be fixed to skin of the living subject. Biphasic electrical pulses are applied between the at least one probe electrode and the at least one body-surface electrode with a peak-to-peak amplitude of at least 1 kV, a frequency of at least 500 kHz, and a current sufficient to cause irreversible electroporation of the myocardial tissue contacted by the at least one probe electrode.

Methods and systems for monitoring and modifying pulsed field ablation (PFA) energy delivery to prevent patient safety risks and/or delivery device failure. In particular, some embodiments provide methods and systems for detecting and preventing arcs and arc-induced plasma, and their causal events, during delivery of pulsed field ablation energy, as well as methods and systems for identifying conditions leading to potential delivery device failure and correcting charge imbalance or asymmetry.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal current generator. Delivery of current to the interventional element can be gradually ramped up during initialization to improve patient comfort and safety.

Disclosed is a method of detecting a short circuit in the jaws of an end effector of a surgical instrument. The method includes applying a sub-therapeutic electrical signal to an electrode located in the jaws of the end effector. The sub-therapeutic electrical signal comprises a sequence of exploratory waveforms comprising pulsed current and voltage waveforms. The method includes detecting a shorted electrode when a measured electrical parameter in the jaws of the end effector is less than a predetermined value and modifying electrical current applied to the shorted electrode by the RF generator.

Disclosed is a method of adapting energy modality due to a short circuit or tissue type grasped in the jaws of an end effector of a surgical instrument. The method includes selecting an electrode in an array of segmented electrodes during a pre-energy activation cycle. The method includes applying a sub-therapeutic electrical signal to the selected electrode to differentiate between a shorted electrode and low impedance tissue grasped in the jaws of the end effector. The method includes determining the selected electrode is shorted based on a measured electrical parameter received by the control circuit after applying the sub-therapeutic electrical signal and blending monopolar and bipolar RF energy. The method includes determining that the selected electrode is shorted and switching output energy of the RF generator between monopolar and bipolar RF energy.

A surgical instrument comprising a jaw assembly is disclosed. The surgical instrument further comprises a motor-driven drive system configured to open the jaw assembly. The surgical instrument also comprises a control system configured to control the drive system and, also, control a power supply system configured to supply electrical power to electrodes defined in the outer surface, or outer surfaces, of the jaw assembly. In use, the surgical instrument can be used to apply mechanical energy and electrical energy to the tissue of a patient at the same time, or at different times. In certain embodiments, the user controls when the mechanical and electrical energies are applied. In some embodiments, the control system controls when the mechanical and electrical energies are applied.