Methods and apparatuses are disclosed for providing pulsed electrical treatment (including high voltage, sub-microsecond pulsed electric energy) to body vessels. The apparatus may include deployable electrodes that conform to transitional surfaces. These apparatuses may include multiple wire loops forming petal-like electrodes configured to expand with an expandable member, such as a balloon.

Devices and methods are described for a minimally invasive procedure offering immediate relief of brain compression and prevention of subdural hematoma re-accumulation. For example, this disclosure describes devices and methods for embolization of bleeding branch vessels of the middle meningeal artery and subdural hematoma drainage in a single endovascular intervention using multimodal catheter-based technology.

Disclosed are systems and methods for determining target characteristics during a laser procedure, comprising (i) obtaining a relationship between (i) a number of pixels associated with a light beam reflected from a target or an object located in proximity to the target on an endoscopic image obtained from a video sensor coupled to an endoscope and (ii) a distance of the target from a tip of the endoscope. The method further comprising (ii) measuring the number of pixels associated with the light beam reflected from the target or the object located in proximity to the target during a procedure, and (iii) based at least in part on the relationship obtained in step (i) and the measured number of pixels in step (ii), determining at least one of a size of the target or a distance of the target from the tip of the endoscope.

Ablation systems and methods of the present disclosure include a catheter including one or more image sensors. The one or more image sensors can facilitate, for example, positioning an ablation electrode at a treatment site of an anatomic structure and, additionally or alternatively, can facilitate controlling delivery of therapeutic energy to a treatment site of an anatomic structure.

A system for altering an energizable instrument for performing a procedure on the subject. The instrument may be tracked during a procedure and a controller may alter operation thereof during the selected procedure. The energizable instrument may have energy provided to a working end to heat a working end to a selected temperature for various procedures such as cutting, coagulation, vaporization, or the like.

A system is provided to treat sleep apnea, with a method of use. The system includes a handpiece which includes at least one penetrating electrode configured to penetrate tissue and one or more temperature sensors. A processor is coupled with the one or more temperature sensors and the at least one penetrating electrode, and a memory is configured to store instructions executable by the processor. The instructions, when executed, are operable to emit, by the at least one penetrating electrode, RF energy from the electrodes to heat a region of a base of a tongue until a target energy is delivered to the region. The instructions are also operable to measure, by the one or more temperature sensors, the temperature of the region.

A method for adjusting the operation of a surgical suturing instrument using machine learning in a surgical suite is disclosed. The method comprises gathering data during surgical procedures, wherein the surgical procedures include the use of a surgical suturing instrument comprising a suturing needle configured to be mechanically advanced through a suturing stroke, analyzing the gathered data to determine an appropriate operational adjustment of the surgical suturing instrument, and adjusting the operation of the surgical suturing instrument to improve the operation of the surgical suturing instrument.

The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.

Disclosed herein is an electroporation system including a catheter shaft, at least one electrode coupled to the catheter shaft at a distal end thereof, and a signal generator. The signal generator is coupled in communication with the at least one electrode. The signal generator supplies a biphasic pulse to the at least one electrode, the biphasic pulse including a first phase having a first polarity, a first initial voltage amplitude, and a first pulse width. The biphasic pulse including a second phase having a second polarity opposite to the first polarity, a second initial voltage amplitude, and a second pulse width, wherein at least one of the first initial voltage amplitude or the first pulse width is different from the second initial voltage amplitude or the second pulse width, respectively. A leading edge of the second phase occurs after an interphase delay following a trailing edge of the first phase.

The present invention relates to systems for use for radio frequency ablation. The systems can include one or more of an ablation tool, power source for use with the ablation tool and a backstop for use in conjunction with the ablation tool during surgical procedures. Preferred ablation tools comprise a series of three or more blade-shaped electrodes disposed in a linear, curved, curvilinear or circular array. The backstops are useful for reducing direct physical and thermal heat transfer injuries to the patient or surgeon during procedures using radiofrequency (RF) ablation devices.