Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

Improved systems and methods for performing laser based treatment of hard and soft tissues, e.g., bone, skin, and connective tissue, are described. The system can feature a laser adapted to produce a peak output power significantly higher than the output power produced by conventional laser-based dental treatment systems. In some instances, the system features high definition imagers for real-time, on-axis visualization and spatial measurement of the surgical region, which can include rendering 3D images. In some implementations, the system is adapted to deliver a laser beam polarized to align with the collagen fibers of bone tissue, to enhance cutting performance. In some implementations, the system is adapted to image the treatment region with polarized light, which can enable improved visualization of nerves and other anatomical structures.

An electrosurgical system includes a radiofrequency (RF) generator having a controller configured to detect an occurrence of a vaporization point of target tissue and a vaporization duration between commencement of delivery of the RF energy and the occurrence of the vaporization point. The controller can apply the vaporization duration to adjust a parameter during subsequent electrode activation, such as RF power level, an electrode activation sequence, a distance between activated electrodes, and a number of activated electrodes. The controller can apply the vaporization duration to determine if whether a predetermined depth of effect has been reached for use in subsequent parameter adjustments.

An electrosurgical apparatus performs a cut or incision on epithelial tissue of the body of a human or animal patient. The apparatus includes a generator system configured to generate a radio-frequency electric signal, and a hand piece held by an operator and having an end provided with a single active electrode electrically connected to the generator system. The electric signal generates a cut or an incision when the active electrode comes into contact with epithelial tissue of the body. The electric signal has a power ranging from 0.5 W-20 W and a frequency ranging from 40 kHz-90 kHz. The energy emitted by the signal is transferred from the active electrode to the tissue of the body through capacitive coupling. The tissue is cut at a peripheral temperature ranging from 45° C.-60° C. The electric circuit is closed to ground through a capacitive effect, as the apparatus does not use a return plate.

An electrosurgical system includes an electrosurgical instrument, an electrosurgical power generating source, and a controller. The electrosurgical instrument includes a shaft extending from a housing. The shaft includes a distal end configured to support an end-effector assembly. The end-effector assembly includes opposing jaw members movably mounted with respect to one another and moveable from a first position in spaced relation relative to one another to at least one subsequent position wherein the jaw members cooperate to grasp tissue therebetween. At least one of the jaw members includes a temperature-sensing electrically-conductive tissue-contacting plate defining a bottom surface. One or more temperature sensors are coupled to the bottom surface. The controller is configured to control one or more operating parameters associated with the electrosurgical power generating source based on one or more signals indicative of a tissue impedance value and indicative of a temperature sensed by the one or more temperature sensors.

An electrosurgical system for treating biological tissue that comprises: an electrosurgical generator to supply microwave energy; a surgical scoping device having a steerable insertion cord for insertion to a treatment site; and an electrosurgical instrument dimensioned to fit within an instrument channel that is located within the insertion cord. The electrosurgical instrument comprises: a flexible coaxial cable arranged to convey the microwave energy; and a radiating tip portion connected at an end of the coaxial cable and configured to receive microwave energy. The radiating tip portion comprises: a coaxial transmission line for conveying the microwave energy; and a needle tip mounted at an end of the proximal coaxial transmission line, wherein the electrosurgical instrument is slidable within the instrument channel to extend the needle tip beyond an end of the instrument channel to puncture biological tissue; the needle tip is arranged to deliver the microwave energy into biological tissue.

Systems, devices, and methods for temperature and pressure management of an anatomic site are provided. A system can include a scope configured to provide a view of an anatomic site, an energy delivery device configured to deliver therapy energy to the anatomic site, a first irrigation conduit configured to transfer fluid to the anatomic site, a first temperature sensor situated to provide first temperature data associated with the anatomic site, and control circuitry electrically coupled to receive the first temperature data, the control circuitry being configured to adjust, based at least in part on the first temperature data, at least one of (i) a first temperature of the fluid, (ii) a flow parameter of the fluid, or (iii) a setting of the energy delivery device to manage a second temperature of the anatomic site.

Embodiments of medical treatment including skin treatment using electrical energy, especially with the primary purpose for skin treatment for aesthetics are described generally herein. Other embodiments may be described and claimed.

The present invention relates to an ablation assembly (100) to treat target regions of a tissue (41) in organs (44) comprising: an ablation catheter (1) comprising an elongate shaft (13) having a longitudinal main direction (X-X), said elongate shaft (13) comprising at least a shaft distal portion (17), said shaft distal portion (17) comprising a shaft distal portion distal end (19);
said ablation catheter (1) comprising an inner lumen (118) arranged within the elongate shaft (13);
said ablation catheter (1) comprising a shaft ablation assembly (20) fixedly disposed at said shaft distal portion (17), the shaft ablation assembly (20) being configured to deliver both thermal energy for ablating said tissue (41) and non-thermal energy for treating said tissue (41); at least a shape setting mandrel (26) disposed within the ablation catheter (1), the shape setting mandrel (26) being insertable within the inner lumen (118) and removable from the inner lumen (118),
wherein the shape setting mandrel (26) is free to move in respect of the inner lumen (118) avoiding any constraint with said shaft distal portion (17) during the shape setting mandrel insertion,
wherein the shape setting mandrel (26) comprises at least a pre-shaped configuration and the shape setting mandrel (26) is reversibly deformable between at least a straight loaded configuration and said pre-shaped configuration,
wherein, when the shape setting mandrel (26) is fully inserted in the shaft distal portion (17), the shape setting mandrel (26) is configured to shape set said shaft distal portion (17) with said pre-shaped configuration.

The invention provides a therapeutic system comprising: a console, wherein the console comprises a controller and an energy generator; a therapeutic device comprising: an operational head configured for transmitting the energy output from to a biological tissue; and a memory device comprising control instructions, wherein said control instructions comprise instructions for controlling the console; a reversible memory operable linkage linking the memory device to the controller; and a reversible connector configured for operably linking the energy generator to the operational head.

Optionally, the energy generator is a generator of ablation energy or heat energy (e.g. RF generator) and the control instructions comprise instructions for controlling the output of the energy generator. Optionally, the control instructions comprise one or more parameters of energy output or an algorithm configured for controlling the energy output. Optionally, the system further comprises one or more secondary therapeutic devices and the control instructions comprise instructions for controlling the one or more secondary therapeutic devices. Optionally, the system further comprises one or more sensors configured for sensing parameters of energy output or biological or environmental effects of the energy output and the control instructions comprise instructions for controlling the energy output and/or secondary therapeutic devices based on the parameters of energy output or biological or environmental effects. In some embodiments, one advantage provided by the present invention is the use of a single console with a plurality of interchangeable reversibly connected therapeutic devices.