Systems and methods for neuromodulation therapy are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, intravascularly positioning a plurality of ablation electrodes within a blood vessel lumen at a treatment site. The method can include analyzing a renal neuromodulation target site of a patient to obtain patient-specific data related to the renal neuromodulation target site, and based on the patient specific data, delivering neuromodulation treatment to the patient via one or more of the ablation electrodes.

A pulse generator for use with an electroporation system is provided. The pulse generator is configured to be coupled to a catheter including a plurality of electrodes and is configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a pulse train having positive and negative pulses, wherein an average charge over the pulse train is zero.

A surgical system comprising a surgical instrument, a generator configured to supply power to an end effector, and a processor configured to run a control program to operate the surgical system is disclosed. The surgical instrument comprises the end effector which includes a first jaw and a second jaw. At least one of the first jaw and the second jaw is moved with respect to one another between an open position and a closed position. Tissue is configured to be positioned between the first jaw and the second jaw. The processor is configured to detect a first parameter of the surgical system, detect at least one user input, and modify the control program in response to the detected first parameter and the at least one user input.

The invention relates to a method for providing control data of an eye surgical laser (18). A control device (20) ascertains (S1) a lenticule geometry of a lenticule (12) to be separated from predetermined visual disorder data of a human or animal eye (36), wherein the lenticule geometry is defined by means of a refractive power value to be corrected and a lenticule diameter, ascertains (S2) a correction value for compensating for a deformation of the lenticule (12), which is generated by at least one contact element (28) of the treatment apparatus (10), wherein the correction value is determined by means of at least one preceding measurement of the treatment apparatus (10), ascertains (S3) a deformation geometry of the lenticule (12), wherein a deformation refractive power value is calculated depending on the refractive power value to be corrected and the correction value and a deformation diameter is calculated depending on the lenticule diameter and the correction value, and provides (S4) control data for controlling the eye surgical laser (18), which uses the deformation geometry for the separation of the lenticule (12).

The invention relates to a method for providing control data of an eye surgical laser (18). A control device (20) ascertains (51) a lenticule geometry of the lenticule (12) to be separated from predetermined visual disorder data of a human or animal eye (36), wherein the lenticule geometry is defined by means of a refractive power value to be corrected and a lenticule diameter, ascertains (S2) a correction value for compensating for a deformation of the lenticule (12), which is generated by at least one contact element (28) of the treatment apparatus (10), wherein the correction value is determined by means of at least one preceding measurement of the treatment apparatus (10), ascertains (S3) a deformation geometry of the lenticule (12), wherein the deformation geometry is defined by means of the refractive power value and a deformation diameter, wherein the deformation diameter is calculated depending on the lenticule diameter and the correction value, and provides (S4) control data for controlling the eye surgical laser (18), which uses the deformation geometry for the separation of the lenticule (12).

The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

Disclosed is an electrically enabled introducer sheath, such as for crossing a septum into a left atrium and guiding a large bore catheter across the septum and into the left atrium. The sheath includes an elongate, flexible tubular body, having a proximal end, a distal end and an electrically conductive sidewall defining a central lumen. A tubular insulation layer surrounds the sidewall and leaves exposed an annular conductive surface at the distal end. The tubular body has a proximal hub, having at least one access port in communication with the central lumen and a connector in electrical communication with the conductive sidewall. The central lumen is configured to receive a radio frequency conducting wire, to facilitate crossing the septum.

Ablation systems and methods of the present disclosure control lesion depth and width such that, for example, wide and shallow lesions can be formed in target tissue in an anatomic structure of a patient during a medical procedure. Such wide and shallow lesions can be useful for treating, for example, thin tissue such as atrial tissue in atria of the heart of the patient.

Systems, devices, and methods described herein relate to generation and delivery of pulsed waveforms, e.g., for therapy delivery in soft tissue ablation procedures. In some embodiments, a pulse generator is configured to generate a voltage pulse train including a plurality of biphasic pulses, each biphasic pulse of the plurality of biphasic pulses including a positive pulse, a negative pulse, and an inter-phase delay separating the positive pulse and the negative pulse. In some embodiments, successive biphasic pulses of the plurality of biphasic pulses can be separated by a pulse-to-pulse delay such that the plurality of biphasic pulses is separated by a plurality of pulse-to-pulse delays, and the plurality of pulse-to-pulse delays can include increasing or decreasing sequences of pulse-to-pulse delays.

Methods for stabilizing pressure within a cryogenic device include receiving a flow rate value corresponding to an expected average mass flow rate of a cryogen through a needle probe of the cryogenic device during a cryotherapy treatment cycle; determining, based on the flow rate value, a target heater power to be applied to a heater associated with the cryogenic device for a treatment cycle, wherein the heater is configured to heat the cryogen; receiving an input for the treatment cycle; causing the cryogen to flow for a period of time toward the needle probe in response to the input; and apply the target heater power to the heater during the treatment cycle so as to heat the cryogen and stabilize pressure within the cryogenic device.