A medical hydrogel is formed by in-situ crosslinking an aldehyde-terminated multi-arm star polyethylene glycol and a polyamino compound. The aldehyde group and the multi-arm star polyethylene glycol are linked by a chemical bond such as an ether bond, an amide bond, an ester bond, a urethane bond, an imine bond, or a urea bond. The molar ratio of the amino in the polyamino compound to the aldehyde group in the aldehyde-terminated multi-arm star polyethylene glycol is 0.4-4.4:1. The polyamino compound is polylysine or a mixture of polylysine and polyethylenimine in a molar ratio of 2-30:3.

Methods and devices for treatment of a uterine cavity to prevent adhesions following a surgical intervention.

A staple cartridge is disclosed. The staple cartridge can include a cartridge body, a plurality of staples, and an implantable layer. The implantable layer can include a piece of lyophilized foam and a plurality of fibers at least partially embedded in the piece of lyophilized foam. The implantable layer can further include a plurality of pores defined in piece of lyophilized foam, and a plurality of pockets, wherein a pocket at least partially surrounds a fiber. A method of forming an implantable layer for use with a surgical staple is also disclosed. The method can comprise obtaining a mold comprising a cavity, placing a plurality of fibers in the cavity of the mold, dispensing a solution into the cavity around the fibers, and lyophilizing the solution in the cavity.

The present disclosure relates to a method for installing a cuff around a target biological structure. The method may include inserting a guidewire through an incision in a patient underneath an exterior surface of a target biological structure, guiding a ramp device over the guidewire to a position underneath the target biological structure such that the target biological structure is partly supported by the ramp device, guiding a cuff deployment tool over the guidewire to the ramp device, the cuff deployment tool comprising an interior volume and a cuff positioned within the interior volume, and causing the cuff from the cuff deployment tool to deploy such that the cuff moves from within the interior volume to an extended position. At least part of the cuff is positioned between the ramp device and the target biological structure in the extended position.

A staple cartridge is disclosed. The staple cartridge can include a cartridge body, a plurality of staples, and an implantable layer. The implantable layer can include an inner portion, an outer portion positioned at least partially around the inner portion, and a plurality of passages formed through the outer portion toward the inner portion. The implantable layer can be porous. An implantable layer can include an outer portion including a plurality of fibers. A method of forming an implantable layer for use with a surgical stapler is also disclosed. The method can include forming at least one passage through an outer surface toward an inner portion of the implantable layer.

Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.

Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.

The application is directed to devices and methods where one or more magnetic or magnetizable implants provides therapeutic benefits to a patient. The implant may be useful for expanding the range of motion of joints or dynamically providing different responses to changing conditions in the body where the implant is placed. An electromagnet is placed on or in a bone on one side of a joint, and another electromagnet or magnetically active material is placed on or in a bone on the opposing side of the joint. The electromagnet may be continuously energized to relieve pressure in the joint space, or may be energized in response to forces applied to the joint.

An objective of the present invention is achieved by a bio-implantable material winding system constituted by a sheet winding system comprising a sheet-shaped bio-implantable material F and a sheet winding device capable of winding the bio-implantable material, said sheet winding device comprising an axle member and a cylindrical member fitted onto the axle member and capable of moving relative to the axle member in the axle direction. The bio-implantable material winding system is configured to be capable of retaining the bio-implantable material in a rolled state in a gap between a leading end part of the axle member and the cylindrical member covering the leading end part. The bio-implantable material is configured to be deployable so as to assume a sheet-like shape when the leading end part of the axle member is exposed and the retaining action by the sheet winding device released.

A staple cartridge is disclosed. The staple cartridge can include a cartridge body, a plurality of staples, and an implantable layer including a plurality of foam fragments, wherein the foam fragments are fused together to form a unitary body. The implantable layer can further include a plurality of intrastitial voids intermediate the foam fragments and/or a plurality of interstitial voids within the foam fragments. A method of forming an implantable layer for use with a surgical stapler is also disclosed. The method can include the steps of obtaining a plurality of foam fragments, heating the foam fragments, and compressing the foam fragments. A method of forming an implantable layer for use with a surgical stapler can also include lyophilizing a solution.