Provided herein are systems and methods for performing localization within a patient. A method of localization within a body comprises providing at least one processor coupled to at least one data storage device, establishing and calibrating a localization coordinate system within a body by executing a first localization mode by the at least one processor, recalibrating the localization coordinate system by executing a second localization mode by the at least one processor, and localizing a device within the localization coordinate system using the first localization mode and the second localization mode, by the at least one processor. The first localization mode can be an impedance-based localization mode and the second localization mode can be magnetic-based localization mode, or vice versa.

In a transcatheter treatment support technique using a combination of a guide wire equipped with a photoacoustic technique and an ultrasonic imaging device, the ultrasonic imaging device estimates a front edge position of the guide wire using a difference between arrival times of photoacoustic waves arriving at an array of elements configuring an ultrasonic probe or a change of an image of the photoacoustic generation source, which depends on a distance of the photoacoustic generation source from an imaging region, and grasps a relationship between an imaging position and the front edge position of the guide wire using the estimation result. This enables visually grasping a relationship between a region (imaging region) from which an image is able to be obtained with reflective waves from a biological body with use of the ultrasonic probe and an insertion object present outside the region, particularly, the front edge of the guide wire.

A method for performing a surgical procedure includes planning a resection of a bone of a patient. A volume of the bone is removed according to the planned resection using a surgical tool. As the bone is removed, data corresponding to a shape and volume of the removed bone is tracked with a computer system operatively coupled to the surgical tool. A prosthesis is implanted onto the bone of the patient based on the tracked data corresponding to the shape of the removed bone.

An ultrasonic wave imaging apparatus is disclosed, including: an ultrasonic probe for irradiating a subject with an ultrasonic wave and receive a reflected wave of the ultrasonic wave and receiving an ultrasonic wave from a beacon inserted into the subject; a probe position-acquiring unit for acquiring a 3D position and an orientation of the ultrasonic probe; a beacon location-acquiring unit for determining a 3D location of the beacon from relative location and speed of the beacon relative to the ultrasonic probe as calculated from an ultrasonic wave image received at the ultrasonic probe and the 3D position and the orientation of the ultrasonic probe as acquired by the probe position-acquiring unit; and a display image formation section for using the ultrasonic wave image of the ultrasonic waves from the ultrasonic probe to form a display image. A corresponding method is also disclosed.

Systems and methods for closed-loop control of heart failure interventional therapies using closed-loop feedback from vascular implanted cardiac health status sensors are disclosed.

Self-locating active markers (SLAMs) can locate themselves with respect to patient's internal anatomy and be physically located and visible in an operating room (OR) coordinate space, which can increase precision of co-registration between augmented reality (AR) systems and medical imaging. Each SLAM may include 9-axis accelerometers and ultrasound technology to locate themselves by orientation and distance to internal skeletal and/or soft tissue anatomy. Multiple SLAMS affixed to skin near operative site at a location visible to a surgical navigation system and/or the surgeon's AR Headset during a procedure may report relative distance changes between their location and internal skeletal anatomy in order to maintain surgical navigation system or AR coordinate system co-registration to the imaged internal coordinate systems. Sequential time of flight calculations from ultrasound array alone or in combination with 9-axis accelerometer data may be used.

According to some embodiments, systems and methods of ultrasonic detection of implantable medical device distraction are provided. The system includes a first elongate member and a second elongate member. The first elongate member has a first end that is configured to be attached to a first location on the skeletal system of a subject, a second end, and at least one landmark identifiable using ultrasound. The second elongate member has a first end that is movably coupled to the second end of the first elongate member, a second end configured to be attached to a second location on the skeletal system, and at least one landmark identifiable using ultrasound. Movement of the first elongate member in relation to the second elongate member causes a corresponding movement of the at least one first landmark in relation to the at least one second landmark which can be detected using ultrasound.

Provided herein are systems and methods comprising localization agents. For example, provided herein are systems and methods for the placement of localization devices within biological systems and the detection of such localization devices for targeted surgeries or other medical procedures. For example, provided herein are systems comprising one or more miniature detectable devices that are placed into a target location and activated by remote introduction of a magnetic field.

A patch includes a sensor layer and adhesive disposed along an outer surface of the sensor layer. The sensor layer has a plurality of sensors, each adapted to measure a value of an electric field, and a plurality of magnets wherein each of the plurality of magnets is collocated with one of the plurality of sensors. Electric field data from the plurality of sensors is provided to a cardiac monitor.

A system for highlighting an instrument in an image includes a probe (122) for transmitting and receiving ultrasonic energy to and from a volume and a marker device (120) configured to respond to a received ultrasonic signal and emit an ultrasonic signal after a delay. The ultrasonic signal includes one or more pulses configured to generate a marker, when rendered, of a given size at a position within an image. A medical instrument (102) is disposed in the volume and includes the marker device. A control module (124) is stored in memory and is configured to interpret the ultrasonic energy received from the probe and from the marker device to determine a three dimensional location of the medical instrument and to highlight the three dimensional location of the marker device with the marker in the image.