In an organ of interest in a patient is emplaced a set of sensors designed to monitor parameters of the organ of interest, including at least nicotinamide adenine dinucleotide level and at least one parameter from among the group consisting of tissue blood flow, blood hemoglobin, and tissue reflectance. Substantially continuously, a vitality index of the organ of interest is computed based at least in part on the parameters monitored by the sensors at the organ of interest. Another point of the patient is monitored continuously for a systemic reference, NADH level and at least two parameters from among the group consisting of blood flow (BF.sub.S), blood hemoglobin, and tissue reflectance. Substantially continuously, a systemic vitality index is computed from the measured systemic parameters. The vitality index of the organ of interest and systemic vitality index are monitored for a divergence in the temporal trend. Based on the detection of the divergence, an alarm is raised to a physician to warn the physician of a change in the patient's condition.

Provided herein are devices, systems, and methods for assessing, treating, and for developing new treatments for pulmonary arterial hypertension (PAH) using pulmonary artery pressure (PAP) values and/or cardiac output (CO) estimates.

In one example, the disclosure relates to a catheter system comprising an elongated body defining a lumen where the elongated body comprises a proximal portion and a distal portion. An anchoring member may be positioned on the proximal portion of the elongated body. The system further comprising at least one sensor configured to be coupled to the elongated body where the at least one sensor may be configured to sense one or more parameters of a fluid within the lumen of the elongate body. Memory configured to be coupled to the elongated body where the memory may be configured to store sensor calibration information. The system configured to calibrate the at least one sensor based on the sensor calibration information stored by the memory.

A device (110), method and system (100) for calculating, estimating, or monitoring the blood pressure of a subject. At least one processor, when executing instructions, may perform one or more of the following operations. A first signal representing heart activity of the subject may be received. A second signal representing time-varying information on at least one pulse wave of the subject may be received. A first feature in the first signal may be identified. A second feature in the second signal may be identified. A pulse transit time based on a difference between the first feature and the second feature may be computed. The blood pressure of the subject may be calculated according to a first model based on the computed pulse transit time and a first set of calibration values, the first set of calibration values relating to the subject.

The design and structure of a physiological fluid collection bag with instant data transmission capabilities, utilizing a micromachined thermal time-of-flight flow sensor as well as integrated pH and calorimetric mass flow sensors for simultaneous and continuous measurement of the instant volumetric flow rate, accumulated total volume, pH and density of data of a collected fluid is disclosed in embodiments. The fluid collection bag includes a collection chamber and storage chamber wherein the sensors are installed inside the storage chamber of the bag and the bag is fully disposable. The fluid collection bag is able to measure the flow rate and instantly relay the data to a reusable data processing unit that can transmit the data to a designated data center or to medical staff.

A method of determining volume flow rate of a bodily fluid in a biological conduit includes determining a cross-sectional area of a biological conduit using a velocity vector map representing moving entities or moving fluid portions in a bodily fluid flowing within the biological conduit, calculating an average speed of the moving entities or moving fluid portions in the bodily fluid flowing across the determined cross-sectional area of the biological conduit, and calculating volume flow rate of the bodily fluid in the biological conduit from the determined cross-sectional area and the calculated instantaneous or average speed. A series of velocity vector maps may be collected over time so as to generate a flow rate profile representing flow rate as a function of time.

The device includes a housing fastenable to a subject's upper arm wherein housing and upper arm have parallel longitudinal axes. The housing accommodates a control circuit including a processing unit, a physiological sensor and an acceleration sensor for providing a sensor signal and an acceleration signal, respectively to the processing unit. The processing unit includes an evaluation function for evaluating the sensor signal and providing a detection signal, a generator function generating a signal indicative of an occurrence of an epileptic seizure from said detection signal, a posture determination function using the acceleration signal and arranged within the housing for establishing an angle between the housing's longitudinal axis and a gravity vector, and for determining whether the angle is within a predetermined range corresponding to the upper arm lying down. The evaluation function further reduces a sensitivity of evaluating the sensor signal when the angle is within the predetermined range.

Hip joint navigation systems and methods are provided. In some embodiments, the systems and methods described herein determine a table reference plane that approximates the Anterior Pelvic Plane. In some embodiments, the systems and methods described herein measure a pre-operative and post-operative point. In some embodiments, the comparison of the pre-operative and post-operative point corresponds to changes in leg length and joint offset. In some embodiments, the systems and methods described herein determine an Adjusted Plane. In some embodiments, the Adjusted Plane adjusts for tilt by rotating the Anterior Pelvic Plane about the inter-ASIS line. In some embodiments, the Adjusted Plane improves correlation between navigated cup angles and post-operative images.

A bio-processor includes a bioelectrical impedance sensor and a digital signal processor. The bioelectrical impedance sensor measures bioelectrical impedance during a sensing time including a portion of a settling time. The digital signal processor estimates a settled bioelectrical impedance value based on changes in the measured bioelectrical impedance. The digital signal processor generates bio-data based on the settled bioelectrical impedance value.

A method and a system are provided for taking biomarker measurements of patients who have ADHD. Mathematical analysis (e.g., pattern recognition, machine learning and AI algorithms) of the biomarker measurements is used to create a unique personal prediction model and data set for an individual patient. The unique personal data set is used to diagnose and monitor a particular problem of the individual patient associated with ADHD, or to recommend a treatment for a particular problem of the individual patient associated with ADHD, or to predict an outcome of a treatment for a particular problem of the individual patient associated with ADHD.