The disclosure extends to methods, systems, and computer program products for validating continual probe contact with tissue during bioelectric testing. The disclosure extends to methods, systems, devices, and computer program products that could be utilized to validate continual probe or probe hood contact with a test subject's tissue or tissue surrounding a test point. The methods, systems, and computer program products may be included with skin or tissue contact validation, warnings, alerts, and systems and procedures that could invalidate a compromised reading and initiate a new reading at the compromised test point.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate. Further, additional improvements in nerve localization and targeting may reduce the number of needle insertions, applied treatment cycles, and may also reduce the number of cartridge changes.

In some examples, a diagnostic device includes a reusable part to receive a container of a fluid, the reusable part reusable for a plurality of diagnostic tests. The diagnostic device further includes a disposable part detachably attached to the reusable part and comprising a sample collector to collect a target sample of a living being. The diagnostic device further includes a tester comprising a fluid channel to transport the fluid to combine the fluid and the target sample to form a fluid combination, and to use the fluid combination to diagnose a condition of the target sample.

A hand held olfactory tester includes an elongated housing (12) with an opening at its forward end (30) thereof. An odorant chamber (22) located within the housing moveable axially between a forward (FIG. 4) and a backward position (FIG. 5). A wick (34) extends from the odorant chamber forwardly into a nozzle (32) carried at the forward end of the chamber. A thumb collar (24) located around the outside of the housing allows to move the odor chamber and nozzle forwardly. The forward end of the wick exposed to outside through the opening when moved forward so that vapors from the odorant can be smelled by a patient. O-rings (40, 42) seal the nozzle from the outside when in backward position to prevent vapors from escaping. An elongated spring (28) biases the odorant chamber and nozzle backwardly into its rear sealed position when the thumb collar is released.

A bio-vibration device for use by a user having a finger for sensing vibration signals in an individual includes a finger coupler device, a vibration sensor and a communications circuit. The vibration sensor is affixed to the finger coupler device and is configured to be pressed against a selected site of the individual so as to sense a vibration signal therefrom. The communications circuit is responsive to the vibration sensor and is configured to transmit the vibration signal to a remote device.

Apparatus for discriminating between tumour tissue and non-tumorous tissue in real-time, the apparatus comprising: a handheld bioimpedance probe having an elongate body and at least four stimulator electrodes mounted on a distal end of the elongate body, the electrodes being arranged to be held against a region of tissue in use; a current source configured to generate a stimulation current; a voltage sensor; a multiplexer coupled between the current source, the voltage sensor and the stimulator electrodes and configured to changeably switch between a plurality of switching configurations, wherein, in each switching configuration, a first two of the electrodes are connected to the current source, and a second two of the electrodes are connected to the voltage sensor, the electrodes that constitute the first two electrodes and the electrodes that constitute the second two electrodes changing from one switching configuration to the next; and processor-controlled circuitry configured to: control the switching configuration of the multiplexer; control the generation of the stimulation current by the current source and the application of the stimulation current to the first two electrodes of each switching configuration, such that, in use, the stimulation current flows through the tissue between the first two electrodes; control the measurement, by the voltage sensor, of the voltage between the second two electrodes of each switching configuration, across the tissue in use; determine, based on the applied current and the measured voltage for each switching configuration, a measure of relative impedance of the tissue for each switching configuration; and supply such impedance measurements as output data to a data analyser to enable real-time discrimination of the tissue to be performed, based on the impedance measurements. A handheld surgical tool is also provided, comprising an elongate body and an adjustable handle member that is pivotally coupled to the elongate body.

A method for preventing obesity related to infection by an adipogenic adenovirus includes obtaining a sample from a person, assaying the sample to determine whether the person has been previously infected with an adipogenic adenovirus, and if the person has not been previously infected, providing the person with at least one sensor positioned to detect when a person's hand approaches a predetermined distance from the person's face. By warning the person of undesired hand-to-face contacts, the person is able to reduce the incidence of obesity related infections. Other embodiments are directed to a kit for preventing obesity caused by infection with an adipogenic adenovirus, such kit including a container for assaying an agent indicating the presence of antibodies to Ad-36, and a sensor positioned on an item selected from the group consisting of one of a hat, a writing instrument, eye glasses, a belt, sunglasses, a bra, a shirt, and a tie.

A probe tip of an oximeter device includes first and second printed circuit boards (PCBs) that are coupled to the ends of optical fibers that transmit light between the PCBs and into patient tissue that is to be measured by the oximeter device. The PCBs are oriented at an angle between zero and ninety degrees so that the fibers have a curved shape between the locations at which the fibers are coupled to the first and second PCBs. The angular orientation of the PCBs and curved shape of the fibers allows the fibers to have a longer length than if the fibers were straight and allows for light transmitted through the fibers to have a uniform distribution across a cross-section of the fibers as the light is emitted from the fibers into patient tissue. The uniform distribution of light transmitted into patient tissue allows for reliable oximetry measurements.

The invention provides a nanoindentation pen in the form of a device for measurement of mechanical properties of a tissue in a subject, the device comprising a dumbbell comprising an elongated shaft, the shaft being affixed at a first end to a pen tip for contacting the tissue, the shaft being affixed at a second opposite end to a terminal member, a linear actuator, and one or more pressure sensors that are in physical communication with the terminal member, the pressure sensor(s) generating a signal that indicates a force exerted on the terminal member by the pen tip via the shaft. In some embodiments, the inventive device uses statics and mechanics to calculate the stiffness of a human vocal fold based on a known displacement and a measured force. The pen tip is able to reach most sides of the vocal fold, making it ideal for all types of examination purposes.

The present disclosure provides a device for measuring the jugular venous pressure of a patient. The device comprises a body defining a longitudinal enclosure and having a window along a length of the longitudinal enclosure to allow light to exit the longitudinal enclosure, a beam generator comprising a moveable portion mounted within the longitudinal enclosure, the beam generator configured to generate a sheet of light along a plane perpendicular to a longitudinal direction and at an adjustable position along the longitudinal direction, and direct the sheet of light out the window, an adjustment mechanism for adjusting the position of the moveable portion of the beam generator relative to the body along the longitudinal direction, and, a readout indicating the position of the sheet of light along the longitudinal direction.