An analyte sensor and methods and systems related thereto, where at least one or more of a lower portion of a sensor tail substrate, at least one electrode, a sensing element, a membrane, and an optional non-electrochemical functional layer comprise an antimicrobial quality. Asymmetric, double-sided adhesive binders suitable for adhering the analyte sensor to a skin surface comprising a non-woven scrim, a first pressure-sensitive adhesive layer, a second pressure-sensitive adhesive layer. Overbandages comprising a vapor-permeable backing, an aperture to circumferentially surround a sensor housing, a contact adhesive layer, first and second peelable release liners, and a third peelable release liner disposed upon an anchoring adhesive strip of the contact adhesive layer.

Example inventions detect an occurrence of disturbance during a sleep period of a user. Examples receive data corresponding to a single parameter of the user during the sleep period, determine patterns in the data, and based on the patterns, determine a sleep disturbance severity index (“SDSI”) over the sleep period.

A watch having a cover is described. An optical sensor subsystem is attached adjacent to or directly on an interior surface of the cover. In some cases, the optical sensor subsystem includes a substrate to which a light emitter and a light receiver are attached. The light receiver is configured to receive light emitted by the light emitter and reflected from the skin of a person that wears the watch. In some cases, the light emitter and light receiver are separated by a light-blocking wall that abuts the interior surface of the cover. In some cases, a light filter is attached adjacent or directly on the interior surface of the cover, between the cover and the light receiver.

A measuring apparatus is configured to be connected to an electrode to measure biopotential. The measuring apparatus has an input box to which the electrode is connected. The input box has a tubular elastic member configured to hold a cap to be mounted on the electrode, and an insertion portion configured such that the elastic member is insertable into the insertion portion. The elastic member has an entrance having a first inner diameter and a contracted portion having a second inner diameter smaller than the first inner diameter.

A leadless pacemaker device configured to provide for an intra-cardiac pacing, including: processing circuitry configured to generate ventricular pacing signals for stimulating ventricular tissue, and a reception device for receiving a sensing signal indicative of an atrial activity, wherein the processing circuitry is configured to detect an atrial event derived from said sensing signal, wherein the atrial event is a valid atrial sense event, where a series of atrial events lie within a range for a normal atrial rate, and/or when the atrial rate variability is within a certain range indicating a regular atrial rhythm, wherein in case a valid atrial sense event is detected, the processing circuitry is further configured to: determine ventricular pacing events according to atrial events, calculate ventricular-atrial time delays, determine a correction value based a measured time delay and the calculated time delay, and adjust the ventricular pacing timing based on the correction value.

Disclosed is a system and method for performing measurements on a biological subject, and in one particular example, to performing measurements of analytes in a biological subject by breaching a functional barrier of the subject using microstructures, wherein the one or more microstructures include an aptamer for binding one or more analytes.

A wearable sensor device includes a temperature and humidity sensor that measures ambient environmental information around a living body, a snap button connected to a bioelectrode, a biological information measurement unit that measures biological information, an inertial sensor that measures inertial information, a calculation unit that calculates a biological feature amount based on the biological information and calculates an inertial feature amount based on the inertial information, and a wireless communication unit that transmits the biological information, the inertial information, the biological feature amount, the inertial feature amount, and the environmental information to the outside.

An implantable medical device includes a header configured to be mounted to an end of a device housing that contains an electronics module therein. The header includes an antenna, a sensing electrode, and a header body that at least partially surrounds the antenna and the sensing electrode. The sensing electrode includes a first body portion, a second body portion, and a bridge portion that mechanically and electrically connects the first and second body portions. The first body portion is at least partially exposed to an external environment along a first side of the header, and the second body portion is at least partially exposed to the external environment along a second side of the header that is different from the first side.

A watch having a cover is described. An optical sensor subsystem is attached adjacent to or directly on an interior surface of the cover. In some cases, the optical sensor subsystem includes a substrate to which a light emitter and a light receiver are attached. The light receiver is configured to receive light emitted by the light emitter and reflected from the skin of a person that wears the watch. In some cases, the light emitter and light receiver are separated by a light-blocking wall that abuts the interior surface of the cover. In some cases, a light filter is attached adjacent or directly on the interior surface of the cover, between the cover and the light receiver.

A deep intracranial electrode which comprises a flexible wire, an electrode contact, a connector and a shield sleeve, one end of the flexible wire is connected to the electrode contact, the other end connected to the connector; the shield sleeve sheathes around the flexible wire, a sum of a length of a part of the flexible wire arranged outside the shield sleeve and a length of the shield sleeve being adjustable. When the shield sleeve sheaths around the flexible wire, the length of the flexible wire inside the radio-frequency magnetic field of the magnetic resonance equipment may equal to a sum of the length of the shield sleeve and a length of the flexible wire outside the shield sleeve.