Various embodiments of the invention provide systems and methods for low-cost, low-power Array Waveguide Grating (AWG)-based miniaturized Raman spectroscopy for use in non-invasive glucose monitoring systems, such as in wearable devices that require no replenishment of chemicals or enzymes. The AWG may be manufactured using VLSI processing technology, which significantly reduces manufacturing cost and replaces holographic grating as the dispersive component of light. In embodiments, the AWG is integrated with a number of PIN photodiode detectors on a substrate to further reduce cost and signal loss. In embodiments, a prism-coupling method eliminates alignment problems associated with traditional approaches that utilize fiber-coupling methods.

A multispectral synchronized imaging system is provided. A multispectral light source of the system comprises: blue, green and red LEDs, and one or more non-visible light sources, each being independently addressable and configured to emit, in a sequence: at least visible white light, and non-visible light in one or more given non-visible frequency ranges. The system further comprises a camera and an optical filter arranged to filter light received at the camera, by: transmitting visible light from the LEDs; filter out non-visible light from the non-visible light sources; and otherwise transmit excited light emitted by a tissue sample excited by non-visible light. Images acquired by the camera are output to a display device. A control unit synchronizes acquisition of respective images at the camera for each of blue light, green light, visible white light, and excited light received at the camera, as reflected by the tissue sample.

An apparatus comprising: a light detector; a light source, laterally offset from the light detector by a first lateral offset; optics configured to receive light emitted by the light source and output the received light, wherein a majority of the light output is directed towards an offset region laterally offset from the light detector by at least a second lateral offset different from the first lateral offset.

A test device is used to test photosensitivity of a skin. The test device is provided with an irradiation unit including a plurality of light irradiation units arranged in a first direction. The plurality of light irradiation units output, in a second direction intersecting the first direction, irradiation light beams that mutually differ at least in one of wavelength characteristics and intensity. The irradiation unit is configured such that intensities of the irradiation light beams output from the plurality of light irradiation units are progressively smaller in the first direction.

A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

A method and apparatus for monitoring brain activity of a user is disclosed. The apparatus includes a plurality of spatially separated emitters operable to generate infrared radiation. The apparatus also includes a plurality of spatially separated infrared radiation detectors, and a plurality of light pipes urged into contact with the user's scalp, each one of the plurality of emitters and detectors having an associated light pipe operable to couple infrared radiation from the emitter into the scalp or to couple infrared radiation from the scalp to the detector. Each detector is operable to produce a signal representing an intensity of infrared radiation generated by a selectively actuated one of the plurality of emitters and received at the detector after traveling on a path through underlying brain tissue, the signals being received by a controller operably configured to process the signals from each detector to determine changes in blood oxygenation within the brain tissue along the path between the respective emitter and detector, and generate a spatial representation of brain activity within in the user's brain based on the processed signals.

A wearable health monitoring device can include a physiological parameter measurement sensor or module configured to be in contact with a wearer's skin when the device is worn by the wearer on the wrist. The physiological parameter measurement sensor can noninvasively and optionally continuously measure one or more physiological parameters, for example, the oxygen saturation, of the wearer. The sensor can include a convex curvature to improve pressure, and therefore optical coupling, between the wearer's skin and the physiological parameter measurement sensor while balancing the pressure and the wearer's comfort. The sensor can include a light barrier between emitters and detectors and other light barriers to improve signal strength and reduce noise.

[Problem] To predict a remaining time during which a fluorescence image is observable.

[Solution] An information processing device according to the present disclosure includes a remaining time estimation unit that estimates, on the basis of a luminance limit value for observation of a fluorescence image and a change in luminance of a fluorescence image, a remaining time until the luminance of the fluorescence image reaches the luminance limit value. This configuration enables the time at which the luminance of a fluorescence image reaches the luminance limit value to be estimated according to a change in luminance of the fluorescence image, and it is possible to predict a remaining time during which a fluorescence image is observable.

An imaging system for a patient is provided. The system includes an imaging probe having an elongate shaft with a proximal end, a distal portion, and a lumen extending between the proximal end and the distal portion. A rotatable optical core is positioned within the lumen of the elongate shaft. An optical assembly is positioned proximate the distal end of the rotatable optical core and is configured to direct light to tissue and collect reflected light from the tissue. An imaging assembly is constructed and arranged to optically couple to the imaging probe and the imaging assembly is configured to emit light into the imaging probe and receive the reflected light collected by the optical assembly.

One or more devices, systems, methods and storage mediums for performing optical coherence tomography (OCT) while detecting one or more lumen edges, one or more stent struts, and/or one or more artifacts are provided. Examples of applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes, catheters, capsules and needles (e.g., a biopsy needle). Preferably, the OCT devices, systems methods and storage mediums include or involve a method, such as, but not limited to, for removing the detected one or more artifacts from the image(s).