The present invention provides a system for intracranial imaging and treatment of an intracranial region including: (a) a catheter probe suitable for insertion into the intracranial region, the catheter probe including: (i) a catheter housing; (ii) an optical probe including one or more optical emitters; and (iii) an optional surgical tool, with the optical probe and the surgical tool located within the housing; and (b) an imaging plate configured for fixed attachment through a plurality of fixed attachment points to a surface of the intracranial region being imaged and treated. The imaging plate includes an array of sensors, each sensor including an optical receiver. The optical emitters are configured to emit light in proximity to the intracranial region being imaged. The array of sensors is configured to measure transmitted light to determine the status of the intracranial region being imaged.

A non-invasive continuous blood sugar level monitoring apparatus integrated with real-time health support system. The blood sugar levels and other vital physiological information of the user can also be tracked wirelessly through the apparatus. The apparatus has an integrated real-time alert and reminder feature for notifying the user during medication and unusual physiological conditions. An automated diet and lifestyle recommendation solution is integrated into the device to help the user maintain healthy blood sugar and blood pressure levels. The low-powered telemetry device is used for communicating the stored physiological information of the user and the computed results between the network of devices.

A wearable optical device is described for optically detecting parameters of interest within muscle, including oxygenation level and/or hemoglobin concentrations. Detected parameters may be used to assess physical performance, such as the extent to which muscle is utilizing aerobic or anaerobic processes. The wearable optical device may include a pressure sensitive strap. Pressure provided by the strap may affect properties of tissue or sensor measurement, for example, by occluding blood flow or mechanically distorting measured tissue. Pressure sensors may be included in the strap, and may be used, for example, to: examine the heterogeneity of a pressure distribution of the strap, allowing a user to manage pressure consistency throughout measurements using the optical device; determine if pressure affects measurements taken by the optical device; and/or manage levels of blood flow restriction, allowing a user to perform exercises with lower levels of oxygen delivery, such as hypoxic training.

A wearable optical device embedded in a garment is described. The optical device is, in some embodiments, an optical sensor for optically detecting parameters of interest within muscle, such as during physical activity or when at rest. The parameters of interest include oxygenation level and/or hemoglobin concentrations in some situations. The detected parameters, such as oxygenation level, may be used to assess physical performance, such as the extent to which the muscle is utilizing aerobic or anaerobic processes. The garment is a compression garment in some embodiments to couple the optical device to a subject.

An electronic fitness device comprises a first optical transmitter array, a first optical receiver, a second optical receiver, and a processing element. The first optical transmitter array includes first optical transmitter operable to transmit a first optical signal having a first wavelength and a second optical transmitter operable to transmit a second optical signal having a second wavelength. The first optical receiver is operable to receive modulated optical signals and generate a first photoplethysmogram (PPG) signal resulting from the first optical signal and a second PPG signal resulting from the second optical signal. The second optical receiver is operable to receive modulated optical signals and generate a third PPG signal resulting from the first optical signal and a fourth PPG signal resulting from the second optical signal. The processing element is operable to determine cardiac information of the user based on the received PPG signals.

A sensor head is provided. In any of the various aspects of the invention, the sensor head has a housing enclosing at least two light sources configured to deliver light to a patient and comprising a blue LED first light source that delivers light at an excitatory wavelength and a green LED second light source, and at least one light detector configured to detect light at an emission wavelength from the patient. The sensor is useful for non-invasive monitoring of fluorescent tracers agents.

A non-invasive continuous blood sugar level monitoring apparatus integrated with a real-time health support system. The blood sugar levels and other vital physiological information of the user can also be tracked wirelessly through the apparatus. The apparatus has an integrated real-time alert and reminder feature for notifying the user during medication and unusual physiological conditions. An automated diet and lifestyle recommendation solution is integrated into the device to help the user maintain healthy blood sugar and blood pressure levels. The low-powered the telemetry device is used for communicating the stored physiological information of the user and the computed results between the network of devices.

Provided are microfluidic systems for monitoring a biofluid property and related methods. Specially configured microfluidic networks and associated structural support and functional elements, including flexible substrates, capping layers, and fluidic conduits and controllers, provide reliable biofluid collection. Optical components and indicators provide a reliable and readily observable readout, including of any of a number of biofluid properties, including directly from biofluid collected in the microfluidic network.

Methods and apparatuses are disclosed for capturing and analyzing images of tissue, such as human skin, using variable polarization. Exemplary devices are described having a detection polarizer via which an area of tissue is imaged and one or more light sources whose emitted light is polarized with one or more source polarizers. In a first such device, one or more of the detection polarizer and a source polarizer is rotatable so as to allow the angle between their polarizations to be varied. An area of tissue can be imaged as the angle is varied. Another device has multiple fixed source polarizers of different polarization orientations, each source polarizer polarizing the light emitted by a corresponding group of light sources which can be selectively activated, thereby enabling the device to illuminate an area of tissue with polarized light of different orientations relative to the orientation of the detection polarizer. Images of an area of tissue captured with different polarizations provide information from different depths, allowing visualization of superficial as well as subsurface features.

An in-ear optical sensor device sits deep within the ear canal of a subject such that is in the cartilaginous region and/or the bony region of the ear canal where effects from temporomandibular joint activity or other movement, and external light, are limited. The device has a lateral housing and a medial articulating head joined at an articulation joint so that the medial articulating head may be angled relative to the lateral housing to help the device fit within tortuous ear canals. The device also includes a seal configured to conform to the shape of the ear canal to physically support the device to further limit movement and block environmental light. An audio receiver is also included in the device.