This relates to an electronic device with dynamically reconfigurable apertures to account for different skin types, usage conditions, and environmental conditions and methods for measuring the user's physiological signals. The device can include one or more light emitters, one or more light sensors, and a material whose optical properties can be changed in one or more locations to adjust the optical path and the effective separation distances between the one or more light emitters and one or more light sensors or the size, location, or shape of the one or more dynamically reconfigurable apertures. In some examples, the material can be a liquid crystal material, MEMS shutter layer, or light guide, which can form the one or more dynamically reconfigurable apertures. In some examples, the light emitters or light sensors or both can be an array of individually addressable optical components.

A combined optical coherent tomography (OCT) pressure sensor system includes an optical cable comprising a single-mode core and a multi-mode core. An OCT optical imaging sensor near a distal end of the optical cable can be inserted into a lumen of a living being. First light exiting a distal end of the single-mode core illuminates an interior of the lumen. The OCT optical imaging sensor acquires image information about the interior of the lumen and transmits an optical signal carrying the image information into the distal end of the single-mode core, toward a proximal end of the single-mode core. An optical pressure sensor attached near the OCT optical imaging sensor receives second light from the distal end of the optical cable, senses ambient pressure within the lumen and transmits an optical signal indicative of the ambient pressure into a distal end of the multi-mode core, toward a proximal end of the multi-mode core.

The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

In some examples, an apparatus may include a laser, a source fiber that delivers the laser radiation to an object, and a detector fiber that receives scattered laser radiation and illuminates a detector array with the scattered laser radiation to form speckles on the detector array. In some examples, the object may be directed illuminated by a laser. The detector array may include a plurality of detectors, and may be positioned to receive the scattered laser radiation from the end of the detector fiber. The distance between the detector array and the end of the detector fiber may be adjustable. A controller may be configured to receive detector data from the detector array, determine a time-dependent intensity autocorrelation function for each detector of a plurality of detectors, and determine an ensemble average autocorrelation function. The apparatus may provide information relating to dynamic processes within the object. Various other methods, systems, and computer-readable media are also disclosed.

A wearable device is described. The wearable device includes a housing having a back cover, and an optical mask on first portions of the back cover. The back cover includes a set of windows, with a first subset of windows in the set of windows being defined by an absence of the optical mask on second portions of the back cover, and a second subset of windows in the set of windows being inset in a set of openings in the back cover. An optical barrier surrounds each window in the second subset of windows. A set of light emitters is configured to emit light through at least some of the windows in the set of windows. A set of light detectors is configured to receive light through at least some of the windows in the set of windows.

A multispectral synchronized imaging system is provided. A multispectral light source of the system comprises: blue, green and red LEDs, and one or more non-visible light sources, each being independently addressable and configured to emit, in a sequence: at least visible white light, and non-visible light in one or more given non-visible frequency ranges. The system further comprises a camera and an optical filter arranged to filter light received at the camera, by: transmitting visible light from the LEDs; filter out non-visible light from the non-visible light sources; and otherwise transmit excited light emitted by a tissue sample excited by non-visible light. Images acquired by the camera are output to a display device. A control unit synchronizes acquisition of respective images at the camera for each of blue light, green light, visible white light, and excited light received at the camera, as reflected by the tissue sample.

A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter-changer or tunable filter is between the tissue and the electronic camera with fluorescent imaging settings and a stimulus wavelength setting, and an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue.

A device includes source and detector sensors. In a specific implementation, the device has two near detectors, two far detectors, and two sources. The two near detectors are arranged closer to the two sources than the two far detectors. A light-diffusing layer covers the two near detectors. The device may be part of a medical device that is used to monitor or measure oxygen saturation levels in a tissue. In a specific implementation, light is transmitted into the tissue and received by the detectors. An attenuation coefficient is first calculated for a shallow layer of tissue. The attenuation coefficient is then used to calculate an attenuation coefficient for a deep layer of tissue.

A method and apparatus for analyzing a substance is disclosed. An optical medium is arranged on a substance surface with at least one region of the optical medium surface in contact with the substance surface. An excitation light beam is emitted through the contacting region of the medium surface (to the substance surface. A measurement light beam is emitted through the optical medium to the contacting region of the medium surface such that the measurement light beam and the excitation light beam overlap on the interface of the optical medium and of the substance surface, on which the measurement light beam is reflected. A deflection of the reflected measurement light beam is detected in dependence on the wavelength of the excitation light beam. The substance is then analyzed based on the detected deflection of the measurement light beam in dependence on the wavelength of the excitation light beam.

A wireless near-infrared spectrometry sensor includes a light source for emitting near-infrared energy into tissue and a light receiver for receiving the near-infrared energy after it exits the tissue. The sensor may include a portable energy source for supplying energy to the light source. A processing module may control the light source and process readings in connection with the light source. A wireless transceiver may be coupled to the processing module for at least one of transmitting and receiving information, wherein the light source emits near-infrared energy at predetermined intervals in order to conserve energy in the portable energy source. The portable energy source may include at least one of a battery, a capacitor, a thermoelectric generator, a kinetic energy transducer, electricity derived from RF energy, and any combination thereof. The sensor may further include a substrate for support and which may be part of a sterile bandage.