Embodiments of the present invention provide an osseointegrative implant and related tools, components and fabrication techniques for surgical bone fixation and dental restoration purposes. In one embodiment an all-ceramic single-stage threaded or press-fit implant is provided having finely detailed surface features formed by ceramic injection molding and/or spark plasma sintering of a powder compact or green body comprising finely powdered zirconia. In another embodiment a two-stage threaded implant is provided having an exterior shell or body formed substantially entirely of ceramic and/or CNT-reinforced ceramic composite material. The implant may include one or more frictionally anisotropic bone-engaging surfaces. In another embodiment a densely sintered ceramic implant is provided wherein, prior to sintering, the porous debound green body is exposed to ions and/or particles of silver, gold, titanium, zirconia, YSZ, α-tricalcium phosphate, hydroxyapatite, carbon, carbon nanotubes, and/or other particles which remain lodged in the implant surface after sintering. Optionally, at least the supragingival portions of an all-ceramic implant are configured to have high translucence in the visible light range. Optionally, at least the bone-engaging portions of an all-ceramic implant are coated with a fused layer of titanium oxide.

An endosseous dental implant assembly includes a dental implant including an abutment portion for connecting to a tooth crown and a hollow base portion defining a cavity therein, and a bio-supportive or biodegradable scaffold carried by the hollow base portion of the dental implant in the biomimetic approach. The abutment portion is formed integrally with the hollow base portion. The scaffold is impregnated with regenerative stem cells, growth factors, biomorphic proteins, or autogenous cells. In the osseointegrated approach, bone graft material can be carried to the extraction socket without a scaffold.

Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.

A prosthesis that contains zirconia and supplements a defective portion of a natural bone, and that is changed to a color approximate to that of the natural bone by a heat treatment after a γ-ray sterilization treatment. The color approximate to that of the natural bone has an L* value of 60 to 90, an a* value of −5 to 10, and a b* value of −5 to 10 in the L*a*b* color space. The highest temperature in the heat treatment is 100° C. to 300° C. The prosthesis is a fixture of a dental implant embedded into and bonded to a natural bone, an abutment, an implant crown, and the like.

A bionic fixing apparatus is provided. The bionic fixing apparatus includes a flexible portion having at least one trench. The trench is disposed on the surface of the flexible portion and has a first end and a second end. An interval is disposed between the first end and the second end. The trench is disposed for spreading the stress applied on the bionic fixing apparatus and preventing stress concentration and stress shielding.

A dental implant made of a material comprising titanium. The implant includes a head portion having a non-rotational feature, a lowermost end opposing the head portion, and a threaded bottom portion for engaging bone between the head portion implant and the lowermost end. The implant further includes a nanocrystalline surface formed on at least a portion of the implant. The nanocrystalline surface includes discrete nanocrystals deposited on a roughened surface of the implant. The roughened surface includes at least one of a grit-blasted surface or an acid-etched surface. A portion of the roughened surface is exposed between at least some of the discrete nanocrystals such that the exposed roughened portion between the discrete nanocrystals is capable of contacting bone.

The porous three-dimensional structure of the implant is made as a three-dimensional body with open through pores and one-side open pores distributed evenly on the internal surface of open pores and connected to the internal surface. Sizes of pores are randomly distributed in the range of 150-300 μm. A reinforcing element is made from titanium or titanium alloy as a mesh with the protrusions evenly distributed on the outer surface of the mesh, and is located on the surface of the three-dimensional body. The method of manufacture and method of installation of one of the variants of the dental implant with the possibility of press fit in the jaw bone immediately after extraction of the tooth without arrest of bleeding are based on the porous three-dimensional structure claimed as well.

Provided herein is a method for forming a periodic microstructure on a surface of zirconia-based ceramics, which are not easily mechanically workable, without causing thermal adverse effects. A zirconia-based ceramic having a surface periodic microstructure is also provided. A linearly or circularly polarized laser beam is irradiated to a zirconia-based ceramic surface, and periodic irregularities are formed in a spot of the laser beam. Stripe-pattern irregularities parallel to the direction of polarization can be formed in a spot of a laser beam by irradiating a linearly polarized ultrashort pulsed-laser beam to a zirconia-based ceramic surface. A mesh-like raised region and a dot-like recessed region can be periodically formed by irradiating a circularly polarized ultrashort pulsed-laser beam to a ceramic surface.

Provided is a medical device including a porous portion and a dense portion, wherein an arithmetic average roughness of a surface of the porous portion is 2.0 μm or greater but 20 μm or less, and wherein an arithmetic average roughness of a surface of the dense portion is less than 2.0 μm.

A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises the act of immersing the microscale roughened surface into a solution containing hydrogen peroxide and a basic solution to produce a nanoscale roughened surface consisting of nanopitting superimposed on the microscale roughened surface. The nanoscale roughened surface has a property that promotes osseointegration.